Cystathionine γ-Lyase Identified as a Key Regulator of Memory and Learning
January 1, 2026
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Brand Name :
N/A
Synonyms :
Rhinanthin, Aucuboside
Class :
Oncology, Metabolic and endocrine, food and supplements, Herbals
Brand Name :
N/A
Synonyms :
Rhinanthin, Aucuboside
Class :
Oncology, Metabolic and endocrine, food and supplements, Herbals
Dosage Forms & Strengths
It is used for investigational and research purpose
Extract
80 mg/kg
10 mg
Off-label:
It is given at 5 mg/kg intraperitoneally for 15 days, displays antioxidant properties and protects the pancreas in rats with streptozotocin-induced diabetes
Moreover, a single intraperitoneal dose ranging from 40 to 200 mg/kg exhibits significant protection against α-amanitin intoxication in mice
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
Action and Spectrum
It has been discovered that the iridoid glycoside aucubin possess hepatoprotective qualities, protecting the liver from damage caused by carbon tetrachloride and alpha-amanitin poisoning. It decreases the reactive oxygen species, lipid buildup, and cell death. It also slows hepatic RNA and protein production. The antioxidant qualities of aucubin were also studied in connection to testicular damage brought on by exposure to nonylphenol. It is well known that NP, a substance formed from alkylphenol ethoxylates, impairs male reproduction. Aucubin therapy also reduced these effects, preserving testicular histology, enhancing sperm parameters, and reestablishing hormonal balance.
Frequency not defined
Vomiting
Diarrhea
Nausea
Blackbox warning
Avoid blood thinners as it causes interactions
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy categories:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology
Aucuba japonica, Eucommia ulmoides, Plantago asiatica, and common verbena all contain aucubin, a monoterpenoid molecule that has the characteristic cyclopentan-[C]-pyran skeleton of iridoids. It is administered at 80mg/kg of dose intraperitoneally and showed protective action in mice and rats against liver damage caused by either carbon tetrachloride or alpha-amanitin.
Pharmacodynamics
Its potential as a treatment was assessed in comparison to testicular damage caused by nonylphenol and (NP), an artificial environment toxin that is known to increase the generation of reactive oxygen species and result in male infertility.Antioxidant enzyme activities were restored, reactive oxygen species (ROS) and lipid peroxidation were decreased, and NP-induced disturbance of hormones, anomalies in sperm, and histological changes in testicular tissues were lessened by AU therapy. Furthermore, AU preserved the integrity of the sperm membrane and prevented NP-induced apoptosis.
Pharmacokinetics
Absorption
Half-life:42.5min
Total body plasma clearance-7.2 ml/min/kg
Distribution
Volume of distribution-346.9 ml/kg
Metabolism
It has poor lipophilicity with low pH stabilization in the stomach fluid, and possible metabolism in the mucous membrane of the stomach and liver and it is metabolised quickly.
Elimination
It is eliminated through the body in form of urine
Administration
The route of administration is intraperitoneally.
Patient information leaflet
Generic Name: aucubin
Pronounced: aw-KYOO-bin
Why do we use aucubin?
Plant-derived aucubin has therapeutic benefits such as immunomodulatory, anti-oxidant, and anti-inflammatory activities. It can reduce the inflammation, show anti-oxidant activity, and alter the immune system.
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