avasopasem

Action and Spectrum

Actions and Spectrum: 

avasopasem manganese is mimetic of the enzyme superoxide dismutase (SOD).Here’s a breakdown of its mechanism of action: 

• Superoxide Dismutase (SOD) Mimetic: SOD enzymes are responsible for catalyzing the conversion of superoxide anion (a highly reactive and damaging free radical) into molecular oxygen and hydrogen peroxide.  
• Reduction of Radiation-Induced Damage: When radiation therapy or chemoradiotherapy is administered, superoxide anions are produced as a byproduct. These superoxide anions can cause oxidative stress and damage normal tissues, leading to oral mucositis and esophagitis.

Drug Interaction

Adverse Reaction

N/A 

Black Box Warning

Black box warning: 

None 

Contraindication / Caution

Contraindications/caution: 

Contraindications: 

N/A 

Caution: 

N/A 

Pregnancy / Lactation

Pregnancy consideration: N/A 

Lactation: N/A 

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Pharmacology

Pharmacology: 

N/A 

Pharmacodynamics: 

N/A 

Pharmacokinetics: 

N/A 

Adminstartion

Administration: 

N/A 

Patient Information Leaflet

Patient information leaflet 

Generic Name: avasopasem 

Why do we use avasopasem? 

avasopasem manganese (also known as GC4419) is an investigational drug being studied for potential therapeutic uses. avasopasem manganese is primarily being investigated for its potential use in reducing radiation-induced side effects, specifically oral mucositis and esophagitis, which are common complications of radiation therapy and chemoradiotherapy. avasopasem manganese aims to protect normal tissues from radiation damage and improve patient outcomes.