bencyclane

Action and Spectrum

Actions and spectrum: 

• Vasodilation: bencyclane acts as a vasodilator, meaning it relaxes and widens blood vessels. This leads to improved blood flow & reduced resistance in the arteries, potentially lowering blood pressure. It is often used in the treatment of conditions associated with poor blood circulation. 
• Muscle Relaxation: bencyclane also possesses muscle relaxant properties. It can help relax smooth muscles, such as those found in blood vessel walls, the gastrointestinal tract, and other internal organs. This muscle relaxation can contribute to its vasodilatory effects. 
• Peripheral Vascular Disorders: bencyclane is primarily used to treat peripheral vascular disorders, such as intermittent claudication and Raynaud’s phenomenon (a condition characterized by decreased blood flow to the extremities, typically the fingers and toes). 
• Cerebral and Peripheral Ischemia: In some cases, bencyclane may be prescribed to improve blood flow in the brain (cerebral ischemia) or to alleviate symptoms associated with poor circulation in various peripheral tissues. 

Drug Interaction

Adverse Reaction

Frequency not defined 

GI effects 

Black Box Warning

Black Box Warning: 

There were no specific black box warnings associated with bencyclane. 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Hypersensitivity: bencyclane should not be used by individuals who have a known hypersensitivity or allergy to the medication or any of its components. 
• Acute Myocardial Infarction: bencyclane is contraindicated in individuals who have recently experienced an acute myocardial infarction (heart attack). It may not be safe for use in these patients. 
• Severe Hypotension: bencyclane’s vasodilatory effects can leads to decreased blood pressure. It should be used with caution in individuals with hypotension and avoided in those with severe hypotension. 
• Severe Cardiac Arrhythmias: The medication should be used cautiously or avoided in individuals with severe cardiac arrhythmias, as it can affect heart rate and rhythm. 
• Pregnancy and Breastfeeding: The use of bencyclane during pregnancy and lactation is not recommended, as its safety in these situations has not been well-established. 

Caution: 

• Cardiovascular Conditions: bencyclane can lower blood pressure and affect heart rate. Therefore, caution is necessary when prescribing it to individuals with pre-existing cardiovascular conditions, like hypertension, cardiac arrhythmias (irregular heart rhythms), or ischemic heart disease. Close monitoring may be required. 
• Orthostatic Hypotension: bencyclane may lead to orthostatic hypotension, a condition in which blood pressure drops significantly when transitioning from a sitting or lying position to standing. Patients should be advised to rise slowly to minimize the risk of dizziness or fainting. 
• Elderly Patients: they may be more susceptible to the blood pressure-lowering effects of bencyclane. Dosing adjustments or closer monitoring may be necessary in this population. 
• Renal Impairment: Patients with impaired kidney function may require dosage adjustments as bencyclane is excreted through the kidneys.  
• Hepatic Impairment: bencyclane is metabolized in the liver, so individuals with impaired liver function may need dosage adjustments.

Comorbidities: 

• Diabetes: The diabetic patients are at an increased risk of developing peripheral vascular disorders, which can lead to poor circulation in the extremities. bencyclane may be prescribed to help improve blood flow in these cases. 
• Hypertension: Hypertension can contribute to the development of peripheral vascular disorders. bencyclane’s vasodilatory effects may be used to manage blood pressure and improve circulation. 
• Chronic Kidney Disease: The chronic kidney disease may experience circulation problems. bencyclane’s dosage may require adjustment in individuals with impaired kidney function. 
• Aging: Aging itself can be a factor contributing to peripheral vascular disorders. Elderly individuals may have decreased circulation due to age-related changes in blood vessels. bencyclane may be prescribed to improve blood flow in this population. 
• Neuropathy: Conditions such as diabetic neuropathy can occur alongside peripheral vascular disorders. bencyclane may help improve blood flow and alleviate some symptoms of neuropathy. 

Pregnancy / Lactation

Pregnancy consideration: pregnancy category: not assigned 

Lactation: excreted into breast milk: unknown 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

bencyclane is a vasodilator medication primarily used to improve blood circulation, particularly in the peripheral vascular system. Its pharmacological action involves relaxing and dilating blood vessels, which reduces peripheral resistance and increases blood flow to the extremities.

This effect is beneficial in conditions characterized by poor circulation, such as peripheral vascular disease and Raynaud’s phenomenon. bencyclane’s mechanism of action also involves inhibiting platelet aggregation, which can further enhance blood flow.

It is typically administered orally and is well-absorbed from the gastrointestinal tract. As a vasodilator, it helps alleviate symptoms associated with impaired blood circulation, such as cold extremities and pain.  

Pharmacodynamics: 

• Vasodilation: bencyclane exerts its vasodilatory effects by relaxing the smooth muscles in blood vessel walls, particularly in peripheral arteries and arterioles. This relaxation leads to an increase in the diameter of the blood vessels, reducing peripheral resistance and making it easier for blood to flow through them. 
• Improved Blood Flow: The vasodilation induced by bencyclane results in increased blood flow to extremities, which can be particularly beneficial in conditions where poor circulation is a problem. This enhanced blood flow helps deliver oxygen and nutrients to tissues, alleviating symptoms such as cold extremities and pain associated with impaired circulation. 
• Antiplatelet Activity: bencyclane also possesses antiplatelet properties. Platelets are blood components involved in clot formation. By inhibiting platelet aggregation, bencyclane can help prevent excessive clotting within blood vessels, reducing the risk of thrombotic events. 
• Reduction in Blood Viscosity: bencyclane may decrease blood viscosity, making blood flow more smoothly through vessels. This can be beneficial in conditions where blood viscosity is elevated, such as in some cardiovascular disorders.

Pharmacokinetics: 

Absorption 

bencyclane is typically administered orally, and it is well-absorbed from the gastrointestinal tract after oral ingestion. The drug enters the bloodstream through the digestive system. 

Distribution 

bencyclane is distributed throughout the body via the circulatory system. It primarily targets blood vessels, where it exerts its vasodilatory effects. Its distribution to target tissues helps improve blood circulation, particularly in the peripheral vascular system. 

Metabolism 

bencyclane undergoes hepatic metabolism in the liver. Specific metabolic pathways and metabolites may vary, but in general, the drug is subject to enzymatic transformations.  

Elimination and excretion 

The elimination of bencyclane and its metabolites occurs through the renal route, meaning they are excreted in the urine. 

Adminstartion

Administration: 

• Dosage: The recommended dosage of bencyclane can vary. It is important to follow dosage instructions provided by healthcare provider. The typical dosage may range from one to several tablets or capsules per day. 
• Timing: bencyclane is usually taken with or immediately after meals. Taking it with food can help improve its absorption and reduce the likelihood of gastrointestinal side effects. 
• Duration of Treatment: The bencyclane duration of action will be based on your medical condition. Follow their recommendations regarding the duration of treatment and whether any adjustments to the dosage are necessary. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: bencyclane 

Pronounced: (ben-si-kleen)  

Why do we use bencyclane? 

• Peripheral Vascular Disease: bencyclane is commonly prescribed to improve blood circulation in individuals with peripheral vascular diseases, such as intermittent claudication. It helps widen blood vessels, which can alleviate symptoms like leg pain, cramps, and cold extremities. 
• Cerebral and Peripheral Arterial Disorders: It can be used in the management of cerebral and peripheral arterial disorders, including those affecting blood vessels in the brain and limbs. By increasing blood flow, it may help reduce symptoms associated with these conditions. 
• Raynaud’s Phenomenon: bencyclane may be prescribed for individuals with Raynaud’s phenomenon, a condition characterized by reduced blood flow to the fingers and toes. The drug’s vasodilatory effects can help alleviate symptoms and prevent attacks. 
• Tinnitus: In some cases, bencyclane is used as part of a treatment regimen for tinnitus. It may help improve blood flow to inner ear and reduce the symptoms of tinnitus.