bendazac

Action and Spectrum

Actions and Spectrum: 

bendazac exerts its anti-inflammatory and analgesic effects by inhibiting the synthesis of prostaglandins. Prostaglandins are chemical messengers in the body crucial to the inflammatory response. They are produced by the enzyme cyclooxygenase (COX), specifically the COX-1 and COX-2 isoforms.

Bendazac inhibits the activity of both COX-1 and COX-2 enzymes, thereby reducing the production of prostaglandins. This action leads to a decrease in inflammation, pain, and other associated symptoms. 

bendazac’s spectrum of activity is primarily limited to treating certain skin conditions. It is commonly used in dermatology to manage inflammatory skin disorders such as contact dermatitis, eczema, and other forms of dermatitis. The drug is typically applied topically as a cream or gel directly to the affected area, allowing it to exert its anti-inflammatory effects locally. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Skin irritation 

Dryness and Peeling 

Photosensitivity 

Black Box Warning

Black box warning: 

None 

Contraindication / Caution

Contraindications/caution: 

Contraindications: 

• Hypersensitivity: bendazac should not be used in individuals with known hypersensitivity or allergy to the drug or its components.  
• Children: Safety and efficacy data for bendazac use in children are limited.  
• Open Wounds or Broken Skin: bendazac is indicated for topical use on intact skin. It should not be applied to open wounds, broken skin, or areas with significant skin damage, as this may lead to systemic absorption and potential adverse effects. 
• Asthma or Allergic Reactions to Aspirin or NSAIDs: Individuals with a history of asthma or allergic reactions to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs) should use bendazac with caution, as there may be an increased risk of allergic reactions or worsening of asthma symptoms. 
• Active Gastrointestinal Ulcers or Bleeding Disorders: bendazac is an NSAID that can irritate the gastrointestinal tract and increase the risk of bleeding.  
• Renal Impairment: Individuals with significant renal impairment may require dose adjustments or close monitoring while using bendazac, as the kidneys primarily excrete the drug. 

Caution: 

• Topical use Only: bendazac is intended for topical use only and should not be ingested or applied to the eyes, mouth, or other mucous membranes. Avoid using it on open wounds or broken skin. 
• Avoid Long-term Use: Prolonged use of topical NSAIDs like bendazac may lead to systemic absorption, increasing the risk of adverse effects of oral NSAIDs. Limit the duration of treatment as per your healthcare provider’s recommendation. 
• Asthma and Respiratory Disorders: If you have a history of asthma or other respiratory disorders, use bendazac cautiously, as NSAIDs may trigger or exacerbate respiratory symptoms in some individuals. 
• Gastrointestinal Effects: Topical NSAIDs like bendazac can still have some systemic absorption, which may lead to gastrointestinal side effects, such as stomach pain, indigestion, or ulcers.  
• Skin Reactions: Some individuals may experience skin irritation or sensitization at the application site.  

Pregnancy / Lactation

Pregnancy consideration: Insufficient data available 

Lactation: Excretion of the drug in human breast milk is unknown 

Pregnancy category: 

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category 

Pharmacology

Pharmacology: 

• Inhibition of Prostaglandin Synthesis: bendazac inhibits the cyclooxygenase (COX) enzyme activity, specifically COX-1 and COX-2. These enzymes are responsible for the conversion of arachidonic acid into prostaglandins. By blocking COX activity, bendazac reduces the production of prostaglandins, which are inflammatory mediators that play a role in the inflammatory response, pain, and fever. 
• Anti-Inflammatory Effect: By inhibiting prostaglandin synthesis, bendazac helps to reduce inflammation. This is particularly useful in treating inflammatory skin conditions, such as contact dermatitis and eczema, where local inflammation is a significant factor. 
• Analgesic Effect: bendazac’s inhibition of prostaglandin synthesis also contributes to its analgesic (pain-relieving) effect. Prostaglandins sensitize pain receptors and contribute to the perception of pain. By reducing their production, bendazac helps alleviate pain associated with inflammatory skin disorders. 
• Antipyretic Effect: Prostaglandins are also involved in regulating body temperature and fever. bendazac’s ability to inhibit prostaglandin synthesis may help reduce fever in certain situations. 

Pharmacokinetics: 

Absorption 

When administered as its lysine salt in a 500 mg oral tablet, bendazac is well absorbed into the human body. bendazac’s maximum plasma concentration (Cmax) ranges from 35 to 55 mg/L. 

Distribution 

With a volume of distribution (Vd) of 0.16 L/kg, bendazac’s apparent distribution throughout the body is relatively low. A lower Vd value suggests that the drug remains primarily in the plasma and does not extensively distribute into tissues. 

Metabolism 

bendazac is extensively metabolized in the body. More than 60% of an administered dose is excreted in the urine as the hydroxylated primary metabolite 5-hydroxybendazac and its glucuronide. The hydroxylation process likely involves adding a hydroxyl group (-OH) to the parent compound bendazac, forming 5-hydroxybendazac. 

Elimination and Excretion 

Approximately 60% of a dose of bendazac is eliminated via the urine as its primary metabolite, 5-hydroxybendazac. Additionally, approximately 15% of the administered dose is eliminated in the urine as unchanged bendazac and glucuronide. The plasma elimination half-life recorded for bendazac is 1.7 to 5.2 hours, with a mean of 3.5 hours. The plasma clearance of bendazac is recorded as 0.018 to 0.054 L/h/kg, with a mean of 0.033 L/h/kg. 

Adminstartion

Administration: 

• Clean and Dry the Affected Area: Before applying bendazac, ensure the affected skin area is clean and dry. Gently wash the area with mild soap and water, and pat it dry with a clean towel. 
• Apply a Thin Layer: Take a small amount of bendazac cream or gel and apply it as a thin layer to the affected skin area. Massage it gently into the skin until it is absorbed. Avoid applying bendazac to open wounds or broken skin. 
• Frequency of Application: The frequency of bendazac application may vary depending on the condition being treated and the specific product. It is typically applied two to four times daily, as directed by a healthcare professional or as indicated on the product label. 
• Wash Hands After Application: After applying bendazac, wash your hands thoroughly to avoid unintentional eye or mouth contact. 
• Avoid Sun Exposure: Some topical medications, including bendazac, can increase skin sensitivity to sunlight. It is advisable to avoid prolonged sun exposure and to use sunscreen and protective clothing when going outdoors. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: bendazac 

Why do we use bendazac? 

bendazac is a non-steroidal anti-inflammatory drug (NSAID) primarily used for its anti-inflammatory and analgesic properties. It is commonly used in dermatology to treat various inflammatory skin conditions. Some of the primary uses of bendazac include: 

• Dermatitis: bendazac is used topically to manage different forms of dermatitis, including contact dermatitis, atopic dermatitis (eczema), and allergic dermatitis. It helps reduce inflammation, redness, itching, and other associated symptoms. 
• Skin Irritations: bendazac can be applied to soothe and alleviate skin irritations caused by various factors, such as insect bites, mild sunburn, or minor skin injuries. 
• Pruritus (Itching): Due to its anti-inflammatory and anti-itch properties, bendazac may be prescribed to relieve itching associated with certain skin conditions. 
• Erythema: bendazac may reduce skin redness, particularly in mild to moderate erythema (skin redness) caused by inflammatory conditions. 
• Psoriasis: In some cases, bendazac may be used as an adjunctive treatment for mild to moderate psoriasis, a chronic skin condition characterized by thickened, red, and scaly patches.