Cystathionine γ-Lyase Identified as a Key Regulator of Memory and Learning
January 1, 2026
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Brand Name :
Quantril, Emete-Con
Synonyms :
Benzquinamida, benzquinamide
Class :
Antiemetic, Antihistaminic, Anticholinergic
Brand Name :
Quantril, Emete-Con
Synonyms :
Benzquinamida, benzquinamide
Class :
Antiemetic, Antihistaminic, Anticholinergic
Dosage Forms & Strengths
Injectable solution
50 mg
Suppositories
100 mg
Chemotherapy Induced Vomiting And Nausea
Chemotherapy induced Nausea and Vomiting/also associated with anesthesia and surgery
It is indicated in the management of nausea and vomiting induced by chemotherapy/also associated with anesthesia and surgery
The usual recommended dose is 50 mg via IM; the dose should be repeated after an hour and then after 3 to 4 hours when required (15 minutes before anesthesia to control vomiting and nausea)
25 mg IV as a single dose slowly and subsequent doses with IM
Dose Adjustments
Limited data is available
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
combining benzquinamide with aclidinium could raise the risk or seriousness of side effects
combining adenosine with benzquinamide may raise the risk or degree of tachycardia
benzquinamide in combination with alfentanil could raise the risk or degree of adverse reactions
combining benzquinamide with amantadine may raise the risk or degree of adverse side effects
the risk or extent of adverse effects can be raised when atropine is combined with benzquinamide
the risk or extent of adverse effects can be raised when azatadine is combined with benzquinamide
the serum concentration of bendroflumethiazide can be raised when it is combined with benzquinamide
the risk or extent of adverse effects can be raised when benzatropine is combined with benzquinamide
Actions:
Benzquinamide is a sedative with antiemetic effects that likely works by blocking histamine H1 receptors and muscarinic acetylcholine receptors.
Spectrum:
Anti-nausea medication stops vomiting by targeting receptors in the body and brain, such as the chemoreceptive trigger zone and vomiting center.
Frequency not defined
Drowsiness
HTN
Insomnia
Excitement
Fatigue
Dizziness
Nervousness
Restlessness
Headache
Black Box Warning:
Benzaquinamide might hide signs of overdose or illnesses like intestinal blockage and brain tumors.
Contraindication/Caution:
Contraindications
Hypersensitivity
Cautions
Renal impairment
Hepatic impairment
HTN
Brain tumour
Arrthymias
Intestinal obstruction
Drug interactions
Pediatrics
Pregnancy
Breastfeeding
Pregnancy/Lactation:
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Benzquinamide probably works by blocking histamine H1 and acetylcholine muscarinic receptors, although its exact mechanism is uncertain.
Pharmacodynamics:
H1-receptor antagonists stop natural histamine effects by binding but not activating H1 receptors.
Muscarinic cholinergic receptor blockers prevent the effects of acetylcholine without activating them.
Pharmacokinetics:
Absorption
The bioavailability is 33-39%.
Distribution
The Protein-bound is 58%.
Metabolism
The drug metabolism occurs in liver.
Excretion and Elimination
The half-life is 40 minutes.
The drug and its byproducts excreted through feces and urine (5 to 10%).
Administration:
Benzquinamide controls vomiting and nausea before anesthesia or surgery, usually through IM or slow IV, and occasionally via rectal suppositories.
Patient information leaflet
Generic Name: benzquinamide
Pronounced: benz-kwuh-NAH-mide
Why do we use benzquinamide?
Benzquinamide prevents nausea and vomiting by affecting the brain’s vomiting center, making it useful for motion sickness and similar conditions. It works by altering neurotransmitters to reduce nausea and prevent vomiting.
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