benzquinamide

Action and Spectrum

Actions:  

Benzquinamide is a sedative with antiemetic effects that likely works by blocking histamine H1 receptors and muscarinic acetylcholine receptors. 

Spectrum:  

Anti-nausea medication stops vomiting by targeting receptors in the body and brain, such as the chemoreceptive trigger zone and vomiting center. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Drowsiness  

HTN  

Insomnia  

Excitement  

Fatigue  

Dizziness  

Nervousness  

Restlessness  

Headache  

Black Box Warning

Black Box Warning:  

Benzaquinamide might hide signs of overdose or illnesses like intestinal blockage and brain tumors. 

Contraindication / Caution

Contraindication/Caution:  

Contraindications  

Hypersensitivity  

Cautions  

Renal impairment  

Hepatic impairment  

HTN  

Brain tumour  

Arrthymias  

Intestinal obstruction  

Drug interactions  

Pediatrics  

Pregnancy   

Breastfeeding  

Pregnancy / Lactation

Pregnancy/Lactation: 

Pregnancy consideration:   

No data is available regarding the administration of the drug during pregnancy.  

Breastfeeding warnings:   

No data is available regarding the excretion of drug in breast milk.  

Pregnancy category:  

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.  

Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.     

Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.     

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.     

Category N: No data is available for the drug under this category.  

Pharmacology

Pharmacology:  

Benzquinamide probably works by blocking histamine H1 and acetylcholine muscarinic receptors, although its exact mechanism is uncertain. 

Pharmacodynamics:  

H1-receptor antagonists stop natural histamine effects by binding but not activating H1 receptors. 

Muscarinic cholinergic receptor blockers prevent the effects of acetylcholine without activating them. 

Pharmacokinetics:  

Absorption  

The bioavailability is 33-39%. 

Distribution  

The Protein-bound is 58%. 

Metabolism  

The drug metabolism occurs in liver. 

Excretion and Elimination 

The half-life is 40 minutes. 

The drug and its byproducts excreted through feces and urine (5 to 10%). 

Adminstartion

Administration:  

Benzquinamide controls vomiting and nausea before anesthesia or surgery, usually through IM or slow IV, and occasionally via rectal suppositories. 

Patient Information Leaflet

Patient information leaflet  

Generic Name: benzquinamide  

Pronounced: benz-kwuh-NAH-mide  

Why do we use benzquinamide?  

Benzquinamide prevents nausea and vomiting by affecting the brain’s vomiting center, making it useful for motion sickness and similar conditions. It works by altering neurotransmitters to reduce nausea and prevent vomiting.