Bifendate

Action and Spectrum

Action and Spectrum:

Bifendate is an inducer of cytochrome proteins, and the detoxification is related with increase in level of cytochrome P450.

This drug works as a protective agent to prevent drug-induced liver dysfunction to enhances the action of CYP450.

Drug Interaction

Adverse Reaction

 Adverse reaction

None

Black Box Warning

Black box warning:

None

Contraindication / Caution

Contraindications/caution:

None

Pregnancy / Lactation

Pregnancy Warnings:

Pregnancy category: N/A

Lactation: Excretion of the drug into the human breast milk is unknown

Pregnancy categories:

• Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.
• Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
• Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
• Category N: There is no data available for the drug under this category.

Pharmacology

Pharmacology

It was observed in the study, that the drug improves liver function, which enhances detoxification and reduces pathological lesions.

Bifendate works as stabilizing agent, so they protect cells from any kind of damage.

Pharmacodynamics

Bifendate is a synthetic intermediate of Schisandrin C. It shows anti-HBV property in research conducted on chronic hepatitis B disorder.

Hepatitis B infection is self-limited or chronic type of disorder, hence there is no proper treatment available for this condition.

Adminstartion

Administration:

The drug is taken orally.

Patient Information Leaflet

Patient information leaflet

Generic Name: Bifendate

Why do we use Bifendate?

Bifendate is used to increase transaminase level which causes due to viral hepatitis infection.

Bifendate has anti-HBV properties and is thus used in the treatment of chronic hepatitis B. The effectiveness of this drug is seen in clinical studies against HBV.