bimatoprost ophthalmic implant

Action and Spectrum

Actions and Spectrum 

Bimatoprost ophthalmic implant is used in ophthalmology to treat conditions such as glaucoma and ocular hypertension.  

The action of bimatoprost ophthalmic implant involves reducing intraocular pressure by increasing the outflow of aqueous humor from the eye. 

Drug Interaction

Adverse Reaction

Frequency defined  

1-10% 

Headache  

>10% 

Conjunctival hyperemia  

<1% 

Iridocyclitis 

Drug hypersensitivity 

Product administered at inappropriate site 

Corneal decompensation 

Uveitis 

Corneal opacity 

Cystoid macular edema 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Patients with known hypersensitivity or allergic reactions to bimatoprost or any of the other ingredients. 
• Bimatoprost should generally be avoided in patients with active eye infections. 

Caution: 

• Caution is advised in patients with a history of macular edema. 
• Bimatoprost should be used with caution in patients with a history of intraocular inflammation. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

Bimatoprost ophthalmic implant is a synthetic prostamide analog. It acts on effects of prostaglandins, specifically prostaglandin F2-alpha analogs. 

Pharmacodynamics 

Bimatoprost ophthalmic implant increases the uveoscleral outflow. It is associated with changes in pigmentation of the iris, eyelash lengthening, thickening, and increased pigmentation. 

Pharmacokinetics 

Absorption   

Bimatoprost ophthalmic implant is absorbed through the cornea. 

Distribution 

Bimatoprost ophthalmic implant is distributed to various tissues, including the eye tissues.  

Metabolism 

Bimatoprost ophthalmic implant undergoes metabolism, primarily in the liver.  

Elimination and excretion 

Bimatoprost ophthalmic implant are excreted mainly through the urine. 

Adminstartion

Administration 

Bimatoprost ophthalmic implant is administered in the form of intracameral biodegradable implant.

Patient Information Leaflet

Patient information leaflet 

Generic Name: bimatoprost ophthalmic implant 

Why do we use bimatoprost ophthalmic implant? 

Bimatoprost ophthalmic implant is used to decrease intraocular pressure (IOP) in patients with open-angle glaucoma and ocular hypertension.