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Brand Name :
Durysta
Synonyms :
bimatoprost ophthalmic implant
Class :
Antiglaucoma, Prostaglandin Agonists
Brand Name :
Durysta
Synonyms :
bimatoprost ophthalmic implant
Class :
Antiglaucoma, Prostaglandin Agonists
Dosage Forms & Strengths
Intracameral biodegradable implant
10 mcg
Open Angle Or Secondary Glaucoma
Administer dose of 10 mcg implant through intracameral administration
Safety and efficacy not determined
Refer to adult dosing
Actions and Spectrum
Bimatoprost ophthalmic implant is used in ophthalmology to treat conditions such as glaucoma and ocular hypertension.
The action of bimatoprost ophthalmic implant involves reducing intraocular pressure by increasing the outflow of aqueous humor from the eye.
Frequency defined
1-10%
Headache
>10%
Conjunctival hyperemia
<1%
Iridocyclitis
Drug hypersensitivity
Product administered at inappropriate site
Corneal decompensation
Uveitis
Corneal opacity
Cystoid macular edema
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
Bimatoprost ophthalmic implant is a synthetic prostamide analog. It acts on effects of prostaglandins, specifically prostaglandin F2-alpha analogs.
Pharmacodynamics
Bimatoprost ophthalmic implant increases the uveoscleral outflow. It is associated with changes in pigmentation of the iris, eyelash lengthening, thickening, and increased pigmentation.
Pharmacokinetics
Absorption
Bimatoprost ophthalmic implant is absorbed through the cornea.
Distribution
Bimatoprost ophthalmic implant is distributed to various tissues, including the eye tissues.
Metabolism
Bimatoprost ophthalmic implant undergoes metabolism, primarily in the liver.
Elimination and excretion
Bimatoprost ophthalmic implant are excreted mainly through the urine.
Administration
Bimatoprost ophthalmic implant is administered in the form of intracameral biodegradable implant.
Patient information leaflet
Generic Name: bimatoprost ophthalmic implant
Why do we use bimatoprost ophthalmic implant?
Bimatoprost ophthalmic implant is used to decrease intraocular pressure (IOP) in patients with open-angle glaucoma and ocular hypertension.
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