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Brand Name :
Velcade
Synonyms :
bortezomib
Class :
Antineoplastics and Proteasome Inhibitors
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Brand Name :
Velcade
Synonyms :
bortezomib
Class :
Antineoplastics and Proteasome Inhibitors
when both drugs are combined, there may be an increase in the hypotensive effect of amifostine
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
may diminish the serum concentration of CYP3A4 inducers
CYP3A strong enhancers of the small intestine may reduce the bioavailability of bortezomib
aminosalicylic acid derivatives
it may increase the myelosuppressive effect of myelosuppressive agents
when both drugs are combined, there may be an increase in the hypotensive effect of blood pressure-lowering agents
when both drugs are combined, there may be an increase in the hypotensive effect of hypotension-associated agents
it may increase or decrease the therapeutic effect of antidiabetic agents
it may increase the hypotensive effect of antipsychotic agents
blood pressure lowering agents
it may increase the hypotensive effect of hypotension-associated agents
it may increase the serum concentration of bortezomib
it may increase the hypotensive effect of hypotension-associated agents
it may decrease the serum concentration of Estrogen Derivatives
bazedoxifene/conjugated estrogens
it may decrease the serum concentration of Estrogen Derivatives
it may decrease the serum concentration of Estrogen Derivatives
it may decrease the serum concentration of Estrogen Derivatives
it may decrease the serum concentration of Estrogen Derivatives
protease inhibitors may reduce the level of serum concentration of hormonal contraceptives
protease inhibitors may reduce the level of serum concentration of hormonal contraceptives
protease inhibitors may reduce the level of serum concentration of hormonal contraceptives
protease inhibitors may reduce the level of serum concentration of hormonal contraceptives
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
may increase the hypoglycemic effect
it increases the efficacy of antidiabetic agents
it increases the efficacy of antidiabetic agents
it increases the efficacy of antidiabetic agents
when both drugs are combined, there may be an increased risk or severity of adverse effects
when both drugs are combined, there may be a high metabolism of bortezomib
the effect of bortezomib is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
fedratinib increases the effect of bortezomib by altering the intestinal/ hepatic CYP3A4 enzyme metabolism
CYP3A4 inhibitors increase the concentration of bortezomib in serum
it increases the effect or level of ruxolitinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
it increases the effect of antidiabetic agents
it increases the effect of antidiabetic agents
fexinidazole may enhance the QTc-prolonging effect of QT-prolonging Agents
may increase the therapeutic effect of Anti-diabetic Agents
Adverse drug reactions:
Frequency defined
>10%
Asthenia
Diarrhea
Anorexia
Anemia
Arthralgia
Headache
Nausea
Constipation
Thrombocytopenia
Peripheral neuropathy
Pyrexia
Vomiting
Insomnia
Limb pain
Neutropenia
Paresthesia
Rash
Cough
Dehydration
URI
Rigors
Frequency Not Defined
Hypotension
Anxiety
Abdominal pain
Dyspepsia
Back pain
Bone pain
Myalgia
Muscle spasms
Pain
Pruritus
Pregnancy warnings:
Breastfeeding warnings:
Pregnancy Categories:
Patient Information Leaflet
Generic Name: bortezomib (Rx)
Pronounced: bore-TEZ-oh-mib
Why do we use bortezomib?
bortezomib is an anticancer drug that belongs to the subclass proteasome inhibitors used to treat multiple myeloma and mantle cell lymphoma.
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