boswellia

Action and Spectrum

Actions and Spectrum: 

The main benefit of boswellia herbal supplement is that it reduces inflammation. It stops the action of several enzymes, including 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2), that cause inflammation in the body.  

boswellia may aid in the relief of symptoms brought on by a variety of inflammatory disorders, including rheumatoid arthritis, inflammatory bowel disease and osteoarthritis by lowering the generation of inflammatory mediators. 

The ability to ease joint pain and enhance physical function in people with osteoarthritis, boswellia has been researched. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Nausea  

Diarrhea 

Black Box Warning

Black Box Warning 

There is currently no black box warning for boswellia herbal supplement. 

Contraindication / Caution

Contraindication/Caution: 

• boswellia should not be taken by pregnant or nursing women unless specifically advised to do so by a healthcare professional. 
• Avoid using boswellia supplements if you have allergies to any of the ingredients in boswellia resin or other plants from the Burseraceae family. 
• boswellia may have little effects on blood thinning. if you suffer from a bleeding disorder or are taking drugs that make you more likely to bleed. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: N/A 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology 

Key inflammatory enzymes like 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) are inhibited by boswellic acids.  

boswellia decreases the formation of inflammatory mediators including leukotrienes and prostaglandins, which are linked to inflammation in the body, by blocking these enzymes. 

Pharmacodynamics 

boswellic acids have an inhibitory impact on COX-2, an enzyme that makes prostaglandins that cause pain and inflammation. boswellia aids in lowering the synthesis of pro-inflammatory prostaglandins by inhibiting COX-2. 

It has been discovered that boswellia affects cytokines, significant signalling molecules involved in immune responses and inflammation, as well as their production and release. 

Pharmacokinetics 

Absorption   

boswellia absorption is affected by several variables, including formulation, dosage form, and individual differences. boswellia chemicals, especially boswellic acids, can have a limited bioavailability because of things like poor solubility and substantial first-pass metabolism.  

Distribution 

boswellia and its active ingredients are transported throughout the body by the bloodstream after absorption.  

Metabolism 

The liver is where boswellia is metabolized predominantly. Enzymes, such as cytochrome P450 (CYP) enzymes, metabolize the boswellic acids, the plant’s main active components.  

Elimination and excretion 

boswellia and its metabolites are mostly eliminated through the urine and feces. The elimination half-life of boswellia compounds has not been well-established. 

Adminstartion

Administration:  

Capsules, tablets, extracts and topical preparations are a few of the common types of boswellia herbal supplements. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: boswellia 

Why do we use boswellia? 

boswellia is mostly recognised for its ability to reduce inflammation. In diseases like osteoarthritis, rheumatoid arthritis, inflammatory bowel disease and asthma, it might help lessen inflammation.  

boswellia has long been used to ease joint discomfort and support joint health. It might be useful for those with illnesses like osteoarthritis and rheumatoid arthritis to lessen their pain, swelling and stiffness. 

For its possible therapeutic effects in respiratory disorders including asthma, boswellia has been researched. It might aid asthma sufferers in improving their breathing and reducing airway irritation.