brilliant blue G ophthalmic

Action and Spectrum

Actions and Spectrum: 

Action: 

When brilliant blue G is injected into the eye, it selectively stains the ILM, which is a thin transparent layer that covers the inner surface of the retina. The dye binds to the ILM, making it more visible and distinguishable from the surrounding tissues. This staining effect allows surgeons to precisely identify and remove the ILM during surgery, as it is often the target for removal in certain retinal conditions.  

Spectrum: 

brilliant blue G has a specific absorption spectrum that makes it suitable for ophthalmic use.  

Drug Interaction

Adverse Reaction

Frequency not defined  

Detachment and cataracts 

Tear 

Complications include retinal break 

Hemorrhage 

Black Box Warning

Black Box Warning:  

None

Contraindication / Caution

Contraindication/Caution:  

Hypersensitivity or Allergy: Individuals with a known hypersensitivity or allergy to this drug or any other components of the formulation should not receive this dye.  

Renal Impairment: Drug is excreted primarily through the kidneys. Patients with severe renal impairment or end-stage renal disease may have difficulty eliminating the dye from their system, leading to an increased risk of adverse effects.  

Pregnancy and Breastfeeding: The safety of brilliant blue G use during pregnancy or breastfeeding has not been established.  

Children: There is limited data on the safety and efficacy of brilliant blue G use in pediatric patients. Its use in children should be carefully considered, and the potential risks and benefits should be evaluated on a case-by-case basis. 

Pre-existing Retinal Conditions: Some pre-existing retinal conditions, such as retinal detachment or macular hole, may have specific contraindications or require caution when using brilliant blue G. The decision to use the dye in such cases should be made by an experienced ophthalmologist, considering the individual patient’s condition. 

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: Excreted into human milk is unknown 

Pregnancy Categories:         

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:  

brilliant blue G is a synthetic dye that has been used in ophthalmology as an adjuvant during surgical procedures, particularly in vitreoretinal surgery. 

Pharmacodynamics:  

Drug acts as a vital dye that selectively stains the internal structures of the eye, allowing surgeons to visualize and differentiate specific tissues. It has a high affinity for the internal limiting membrane (ILM) and the inner limiting membrane of the retina, which facilitates their identification and manipulation during surgery. The staining effect of drug enhances the contrast between the tissues, making it easier for surgeons to perform delicate procedures.   

Pharmacokinetics: 

Absorption 

When applied topically as an ophthalmic solution, brilliant blue G is absorbed through the conjunctiva and cornea. However, the extent of systemic absorption is generally low. 

Distribution 

After absorption, brilliant blue G distributes within the eye, specifically staining the targeted tissues, such as the ILM. It does not readily cross the blood-retinal barrier. 

Metabolism 

The metabolism of brilliant blue G in humans is not well documented. However, it is believed that the dye undergoes some level of metabolism in the body, likely through enzymatic processes. Further research is needed to fully understand the metabolic pathways and potential metabolites. 

Excretion and Elimination 

brilliant blue G and its metabolites are primarily eliminated from the body through renal excretion. The dye is excreted in urine after undergoing renal filtration. 

Adminstartion

Administration:  

Staining: brilliant blue G is applied to the eye to stain the targeted tissue, such as the internal limiting membrane. The dye helps to visualize and distinguish the tissue from the surrounding structures. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: brilliant blue G ophthalmic 

Why do we use brilliant blue G ophthalmic?  

Membrane Staining:  The drug is used to stain the internal limiting membrane (ILM) during vitreoretinal surgery, particularly in cases of macular hole repair and epiretinal membrane removal. The dye helps to enhance the visualization and identification of the thin transparent membrane, aiding surgeons in its precise removal. 

Anterior Capsule Staining: During cataract surgery, The drug can be used to stain the anterior capsule of the lens.