bromotheophylline

Action and Spectrum

Action and Spectrum: 

It belongs to the class of Xanthine derivatives and used as a diuretic. It is mainly used for the relief of temporary water weight gain, swelling, bloating associated with the premenstrual and menstrual periods. 

Drug Interaction

Adverse Reaction

Frequency not defined

Hives

swelling of face, tongue, lips, or throat.

difficult breathing

gold-colored urine

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

• It has a narrow range of therapeutic index, caution is needed so as to avoid the toxicity. 
• It may cause tachycardia or arryhthmias, caution is needed in patients with cardiac disorders. 
• May cause gastrointestinal disorders such as bloating, nausea. 

Pregnancy / Lactation

Pregnancy warning: Insufficient data available 

Lactation: Excretion of drug in human breast milk is unknown 

Pregnancy Categories: 

Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the 1st trimester or 2nd trimester. 

Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women. 

Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women. 

Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology 

It facilitates the movement of substances across the kidney’s renal tubule, enhances the efficiency of blood filtration in the glomerulus, and inhibits the reabsorption of sodium in the renal tubule. 

Pharmacodynamics 

The diuretic action causes an immediate output of urine. This thereby helps in reducing bloating and menstrual pain.  

Pharmacokinetics 

Absorption 

Peak plasma concentration:2.5mg/l  

Area under the curve for the first eight hours:27mg.h/L. 

Distribution 

It has large volume of distribution to the lungs. 

Metabolism 

It involves hepatic metabolism through CYP1A2 enzyme 

Elimination and Excretion 

The drug is excreted renally. The elimination half life is 21.35 hours 

Adminstartion

Administration 

It is taken orally after the meals. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: bromotheophylline 

Pronounced: (BROH-moh-thee-OFF-uh-leen) 

Why do we use bromotheophylline? 

Bromotheophylline, a diuretic, increases the production of urine thereby helps to reduce bloating and alleviate menstrual cramps.