Cystathionine γ-Lyase Identified as a Key Regulator of Memory and Learning
January 1, 2026
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Brand Name :
Premsyn Pms, Pamprin Multi-symptom
Synonyms :
bromotheophylline
Class :
Xanthine derivatives
Brand Name :
Premsyn Pms, Pamprin Multi-symptom
Synonyms :
bromotheophylline
Class :
Xanthine derivatives
Dosage Forms & Strengths
Tablet/Capsule
25 mg
600 mg
900 mg
Take one tablet/capsule after the breakfast with a glass of water. Dose can be repeated every six hours, should not exceed more than four capsules daily
Chronic Obstructive Pulmonary Disease (COPD)
Take one tablet/capsule after the breakfast with a glass of water. Dose can be repeated every six hours, should not exceed more than four capsules daily
Safety and efficacy were not established
Refer to the adult dosing regimen
When bromotheophylline is used together with somatotropin, this leads to a rise in bromotheophylline’s metabolism
bromotheophylline may increase the excretion rate of almasilate, potentially lowering serum levels and reducing efficacy
may increase the toxic effects
may increase the toxic effects of opioid agonists
the rate of metabolism of bromotheophylline may be reduced
the rate of metabolism of bromotheophylline may be reduced
Action and Spectrum:
It belongs to the class of Xanthine derivatives and used as a diuretic. It is mainly used for the relief of temporary water weight gain, swelling, bloating associated with the premenstrual and menstrual periods.
Frequency not defined
Hives
swelling of face, tongue, lips, or throat.
difficult breathing
gold-colored urine
Black Box Warning:
None
Contraindication/Caution:
Pregnancy warning: Insufficient data available
Lactation: Excretion of drug in human breast milk is unknown
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the 1st trimester or 2nd trimester.
Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.
Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.
Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
It facilitates the movement of substances across the kidney’s renal tubule, enhances the efficiency of blood filtration in the glomerulus, and inhibits the reabsorption of sodium in the renal tubule.
Pharmacodynamics
The diuretic action causes an immediate output of urine. This thereby helps in reducing bloating and menstrual pain.
Pharmacokinetics
Absorption
Peak plasma concentration:2.5mg/l
Area under the curve for the first eight hours:27mg.h/L.
Distribution
It has large volume of distribution to the lungs.
Metabolism
It involves hepatic metabolism through CYP1A2 enzyme
Elimination and Excretion
The drug is excreted renally. The elimination half life is 21.35 hours
Administration
It is taken orally after the meals.
Patient information leaflet
Generic Name: bromotheophylline
Pronounced: (BROH-moh-thee-OFF-uh-leen)
Why do we use bromotheophylline?
Bromotheophylline, a diuretic, increases the production of urine thereby helps to reduce bloating and alleviate menstrual cramps.
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