RYBREVANT FASPRO™ Receives FDA Approval for First-Line EGFR-Mutated NSCLC
December 26, 2025
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Longifene, Longimax
Synonyms :
buclizine
Class :
Antihistamines, Antiallergics
Brand Name :
Longifene, Longimax
Synonyms :
buclizine
Class :
Antihistamines, Antiallergics
Dosage Forms & Strengths
Tablet
25 mg
Syrup
200 ml
Take a dose of 25 to 50 mg orally as a single dose before travelling
Daily should not be more than 100 mg
Take a dose of 25 to 50 mg orally as a single dose
Not determined
Refer to adult dosing
When ponesimod is used together with buclizine, this leads to enhanced risk or seriousness of bradycardia
When buclizine is used together with adenosine, this leads to enhanced risk or seriousness of QTc prolongation
When buclizine is used together with givinostat, this leads to enhanced risk or seriousness of Qtc prolongation
When buclizine is used together with profenamine, this leads to enhanced risk or seriousness of adverse events
the risk of tachycardia may be increased
the risk of tachycardia may be increased
Actions and Spectrum
buclizine is classified as a first-generation antihistamine. It blocks the H1 receptors, it can reduce the symptoms associated with histamine release. buclizine also has antiemetic properties. It blocks signals in the brain that trigger nausea and vomiting.
Frequency not defined
Blurred vision
Diarrhea
Drowsiness
Dizziness
Headache
Dyspepsia
Dry mouth
Skin and subcutaneous tissue disorders
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: C
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
buclizine has antiemetic properties, which means it helps to prevent and alleviate nausea and vomiting. It does so by affecting the chemoreceptor trigger zone (CTZ) in the brain, reducing the signals that lead to nausea and vomiting.
Pharmacodynamics
buclizine can cross the blood-brain barrier, allowing it to exert its effects within the central nervous system. This can lead to sedation and drowsiness, which is often utilized in managing motion sickness or sleep disorders.
Pharmacokinetics
Absorption
buclizine is well-absorbed from the gastrointestinal tract.
Distribution
buclizine is distributed throughout the body.
Metabolism
buclizine undergoes metabolism in the liver.
Elimination and excretion
buclizine is eliminated from the body through the urine.
Administration
buclizine is taken orally in the form of tablets and syrup.
Patient information leaflet
Generic Name: buclizine
Why do we use buclizine?
buclizine is used to prevent and alleviate symptoms of motion sickness.
buclizine can be used to treat nausea and vomiting caused by various factors.
buclizine is used to alleviate symptoms of allergic reactions, such as itching, sneezing, and runny nose.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
