buclizine

Action and Spectrum

Actions and Spectrum 

buclizine is classified as a first-generation antihistamine. It blocks the H1 receptors, it can reduce the symptoms associated with histamine release. buclizine also has antiemetic properties. It blocks signals in the brain that trigger nausea and vomiting. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Blurred vision 

Diarrhea 

Drowsiness  

Dizziness 

Headache  

Dyspepsia  

Dry mouth  

Skin and subcutaneous tissue disorders 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• buclizine should not be used by individuals who have a known hypersensitivity or allergy to its components. 

Caution: 

• buclizine should be used with caution in pregnant or breastfeeding individuals.  
• Individuals with liver or kidney impairment should use buclizine with caution. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: C 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

buclizine has antiemetic properties, which means it helps to prevent and alleviate nausea and vomiting. It does so by affecting the chemoreceptor trigger zone (CTZ) in the brain, reducing the signals that lead to nausea and vomiting.  

Pharmacodynamics 

buclizine can cross the blood-brain barrier, allowing it to exert its effects within the central nervous system. This can lead to sedation and drowsiness, which is often utilized in managing motion sickness or sleep disorders. 

Pharmacokinetics 

Absorption   

buclizine is well-absorbed from the gastrointestinal tract. 

Distribution 

buclizine is distributed throughout the body. 

Metabolism 

buclizine undergoes metabolism in the liver. 

Elimination and excretion 

buclizine is eliminated from the body through the urine. 

Adminstartion

Administration 

buclizine is taken orally in the form of tablets and syrup. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: buclizine 

Why do we use buclizine? 

buclizine is used to prevent and alleviate symptoms of motion sickness.  

buclizine can be used to treat nausea and vomiting caused by various factors. 

buclizine is used to alleviate symptoms of allergic reactions, such as itching, sneezing, and runny nose.