buflomedil

Action and Spectrum

Actions and Spectrum: 

Actions: 

Vasodilation, or the enlargement of blood vessels, is brought on by buflomedil. This happens as a result of its effects on vascular smooth muscle cells, which cause the smooth muscle to relax and the blood vessel width to grow. 

Spectrum: 

The majority of buflomedil’s effects are vasodilatory, especially in the peripheral vasculature. These effects include peripheral vasodilation, blood flow improvement, enhanced oxygen delivery, increased nutrient delivery, microcirculation effects, relief from intermittent claudication symptoms, improved exercise tolerance, adjunctive therapy in peripheral vascular diseases, and more. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Flushing 

GI disturbances 

Dizziness 

Vertigo 

Rash 

Headache 

Pruritis 

Cephalea 

Syncope 

Paraesthesia 

Itching 

Light headedness 

Black Box Warning

Black Box Warning: 

Patients who suffer from the following illnesses should be treated with extreme caution: 

could impair one’s capacity to operate machinery or drive 

Hepatic or renal dysfunction 

Inform your doctor or pharmacist before using this medication if you have any allergies or other drug-related hypersensitivity responses. This medication may include inactive components that result in adverse reactions or other problems. For further information, speak with your pharmacist. 

Contraindication / Caution

Contraindication/Caution: 

Contraindications 

• Hypersensitivity 
• Cardiovascular diseases 
• Hemorrhagic syndrome 
• Pregnant women (3 months) 
• Intracranial HTN 
• Valvular stenosis 
• Glaucoma 
• During or after 2 weeks of treatment with Monoamine oxidase inhibitors 
• Decrease in pulmonary circulation bed size significantly 
• Cautions 
• Increased risk of bleeding 
• Renal impairment 
• Hepatic impairment 
• Drug interactions 
• Pregnancy  
• Breastfeeding 

Pregnancy / Lactation

Pregnancy consideration:  

No data is available regarding the administration of the drug during pregnancy. 

Breastfeeding warnings:  

No data is available regarding the excretion of drug in breast milk. 

Pregnancy category: 

Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology: 

Buflomedil produces vasodilating effects by improving platelet inhibition, muscle cell metabolism, and RBC deformability. 

Pharmacodynamics: 

Being a vasodilator, buflomedil causes the smooth muscle in blood vessel walls to relax, increasing the diameter of the blood vessels. Peripheral arteries exhibit a particularly noticeable effect of this. Buflomedil improves blood flow to peripheral tissues by widening blood arteries. This helps improve muscle function, relieve symptoms related to poor circulation, and supply oxygen and nutrients to the muscles. 

Pharmacokinetics: 

Absorption 

Plasma concentrations peaked 1.5–4 hours after oral administration; absorbed from the GI tract 

Distribution 

It is widely dispersed. Dose-dependent and ranging from 60-80% binding to plasma protein. 

Metabolism 

Metabolized in the liver. 

Elimination and Excretion 

Half-life of elimination: 2-3 hours. mostly eliminated as unmodified medication and its metabolites in the urine. 

Adminstartion

Administration: 

Tablets of buflomedil are typically taken orally along with a glass of water. The medication can be taken with or without food, depending on the doctor’s instructions. 

Individualized dosages of buflomedil are determined by taking into account the patient’s age, weight, ailment severity, and other medical criteria. It’s critical to take medications exactly as directed and to avoid missing or exceeding dosages without first contacting your doctor.

The healthcare professional will decide on the frequency of administration (e.g., once or twice daily). Following the prescribed dosage schedule is crucial for achieving the best possible therapeutic outcomes. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: buflomedil 

Pronounced: BUF-loh-MEH-dil 

Why do we use buflomedil? 

Buflomedil is a drug that helps to dilate blood vessels because of its vasodilatory qualities. It is mainly recommended to treat intermittent claudication and other peripheral vascular disorders. Due to decreased blood flow, intermittent claudication is a disorder marked by pain, cramping, and weakening in the leg muscles, especially during physical exercise.