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Brand Name :
Loftyl
Synonyms :
buflomedil
Class :
Peripheral vasodilators, Others
Brand Name :
Loftyl
Synonyms :
buflomedil
Class :
Peripheral vasodilators, Others
Dosage Forms & Strengths
Tablet
300 mg
600 mg
Injectable solution (IV/IM)
200 mg
400 mg
Buflomedil is a vasodilator medication that improves muscle cell metabolism, platelet aggregation inhibition, and the deformability of red blood cells (RBC)
It is a mild calcium channel blocker and an inhibitor of alpha-adrenoceptors
The recommended usual dose is 300-600 mg via oral administration in a day
The recommended usual IM dose is up to max 100 mg in a day
The recommended usual IV dose via slow IV injection is up to max 200 mg in a day or up to max 400 mg in a day by infusion
Dose Adjustments
Limited data is available
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
combining buflomedil and abciximab may increase the likelihood or intensity of bleeding
combining buflomedil with abrocitinib may increase the incidence or severity of bleeding and thrombocytopenia
buflomedil may lessen zolofenopril's antihypertensive effects
when zimelidine and buflomedil are combined, there is a chance that the risk or intensity of bleeding will rise
buflomedil may lessen tolazoline's antihypertensive effects
buflomedil may lessen Timolol's antihypertensive effects
buflomedil may intensify avanafil's hypotensive effects
buflomedil may lessen Bepridil's antihypertensive effects
combining carprofen with buflomedil may increase the likelihood or intensity of bleeding
Actions and Spectrum:
Actions:
Vasodilation, or the enlargement of blood vessels, is brought on by buflomedil. This happens as a result of its effects on vascular smooth muscle cells, which cause the smooth muscle to relax and the blood vessel width to grow.
Spectrum:
The majority of buflomedil’s effects are vasodilatory, especially in the peripheral vasculature. These effects include peripheral vasodilation, blood flow improvement, enhanced oxygen delivery, increased nutrient delivery, microcirculation effects, relief from intermittent claudication symptoms, improved exercise tolerance, adjunctive therapy in peripheral vascular diseases, and more.
Frequency not defined
Flushing
GI disturbances
Dizziness
Vertigo
Rash
Headache
Pruritis
Cephalea
Syncope
Paraesthesia
Itching
Light headedness
Black Box Warning:
Patients who suffer from the following illnesses should be treated with extreme caution:
could impair one’s capacity to operate machinery or drive
Hepatic or renal dysfunction
Inform your doctor or pharmacist before using this medication if you have any allergies or other drug-related hypersensitivity responses. This medication may include inactive components that result in adverse reactions or other problems. For further information, speak with your pharmacist.
Contraindication/Caution:
Contraindications
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Buflomedil produces vasodilating effects by improving platelet inhibition, muscle cell metabolism, and RBC deformability.
Pharmacodynamics:
Being a vasodilator, buflomedil causes the smooth muscle in blood vessel walls to relax, increasing the diameter of the blood vessels. Peripheral arteries exhibit a particularly noticeable effect of this. Buflomedil improves blood flow to peripheral tissues by widening blood arteries. This helps improve muscle function, relieve symptoms related to poor circulation, and supply oxygen and nutrients to the muscles.
Pharmacokinetics:
Absorption
Plasma concentrations peaked 1.5–4 hours after oral administration; absorbed from the GI tract
Distribution
It is widely dispersed. Dose-dependent and ranging from 60-80% binding to plasma protein.
Metabolism
Metabolized in the liver.
Elimination and Excretion
Half-life of elimination: 2-3 hours. mostly eliminated as unmodified medication and its metabolites in the urine.
Administration:
Tablets of buflomedil are typically taken orally along with a glass of water. The medication can be taken with or without food, depending on the doctor’s instructions.
Individualized dosages of buflomedil are determined by taking into account the patient’s age, weight, ailment severity, and other medical criteria. It’s critical to take medications exactly as directed and to avoid missing or exceeding dosages without first contacting your doctor.
The healthcare professional will decide on the frequency of administration (e.g., once or twice daily). Following the prescribed dosage schedule is crucial for achieving the best possible therapeutic outcomes.
Patient information leaflet
Generic Name: buflomedil
Pronounced: BUF-loh-MEH-dil
Why do we use buflomedil?
Buflomedil is a drug that helps to dilate blood vessels because of its vasodilatory qualities. It is mainly recommended to treat intermittent claudication and other peripheral vascular disorders. Due to decreased blood flow, intermittent claudication is a disorder marked by pain, cramping, and weakening in the leg muscles, especially during physical exercise.
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