butamirate citrate

Action and Spectrum

Actions and Spectrum 

Action: 

Butamirate citrate acting on the medulla oblongata and suppresses cough. This brainstem area controls vital functions like breathing and heartbeat. It reduces sensitivity of sensory nerves in the respiratory tract, easing coughing. It is effective in treating dry or wet cough and other conditions like inflammation in bronchus, larynx, and pharynx. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Diarrhea 

Dizziness 

Drowsiness 

Nausea 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

If a patient with an history of known hypersensitivity or allergy to butamirate citrate or any of its ingredients, they should not use this drug. 

Caution: 

Patients with COPD or asthma should be treated carefully. 

Patients using this drug should avoid tasks requiring mental alertness like driving or operating heavy machinery. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: While breastfeeding, this syrup should be avoided. 

Pregnancy Categories: 

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments 

Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology 

Butamirate citrate works by suppressing the cough reflex in the brainstem. 

It decreases respiratory tract nerve sensitivity, reducing coughing. 

Pharmacodynamics 

It has slight mucolytic effects, aiding in mucus clearance by softening it. 

It suppresses the cough reflex center in the brainstem’s medulla oblongata. 

Pharmacokinetics 

Absorption 

Butamirate citrate is well absorbed from the gastrointestinal tract. 

Distribution 

Butamirate citrate is distributed widely throughout the body. 

Metabolism 

Butamirate citrate undergoes hepatic metabolism. 

Excretion and Elimination 

Butamirate citrates are primarily excreted in the urine. 

Adminstartion

Administration 

Butamirate citrate is administered orally in the form of syrup. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: butamirate citrate 

Why do we use butamirate citrate? 

Butamirate citrate effectively relieves coughs and provides relief for dry, irritating cough symptoms, especially those linked with respiratory infections like laryngitis, pharyngitis, and bronchitis.