- March 15, 2022
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Brand Name :
Cometriq, Cabometyx
Synonyms :
Cabozantinib
Class :
Antineoplastics and Tyrosine Kinase Inhibitor
Dosage Forms & Strengths
Capsule
20mg
80mg
Tablet
20mg
40mg
60mg
140
mg
orally
once a day
If BSA > or equal to 1.2 m2, 60 mg given orally per day
The treatment needs to be continued until disease progression or unacceptable toxicity occurs
60
mg
orally
once a day
The treatment needs to be continued until disease progression or unacceptable toxicity occurs
when given with a combination of nivolumab
40 mg given orally once a day
The treatment needs to be continued until disease progression or unacceptable toxicity occurs
60
mg
orally
once a day
The treatment needs to be continued until disease progression or unacceptable toxicity occurs
Dosage Forms & Strengths
Tablet
20mg
40mg
60mg
If BSA > or equal to 1.2 m2, 60 mg given orally per day
If BSA < or equal to 1.2 m2, 40 mg given orally per day
The treatment needs to be continued until disease progression or unacceptable toxicity occurs
cabozantinib :they may diminish the serum concentration of CYP3A4 Inducers
cabozantinib :they may diminish the serum concentration of CYP3A4 Inducers
cabozantinib :they may diminish the serum concentration of CYP3A4 Inducers
cabozantinib :they may diminish the serum concentration of CYP3A4 Inducers
cabozantinib :they may diminish the serum concentration of CYP3A4 Inducers
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be a decreased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be a decreased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be a decreased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be a decreased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be a decreased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4
It may enhance the effect when combined with lonafarnib by affecting CYP3A4 metabolism
nafcillin will decrease the effect of action of cabozantinib by affecting enzyme CYP3A4 metabolism.
CYP3A strong enhancers of the small intestine may reduce the bioavailability of cabozantinib
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib
when both drugs are combined, there may be an increased effect of cabozantinib
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be an increased effect of cabozantinib
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the serum concentration when combined with CYP3A4 Inhibitors (Moderate)
It may enhance the effect when combined with grapefruit by CYP3A4 metabolism
Combining cabozantinib with pranlukast may cause a reduction in the cabozantinib’s metabolism
Combining tegafur with cabozantinib can reduce tegafur’s metabolism
when both drugs are combined, there may be a decreased metabolism of paclitaxel
the effect of cabozantinib is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
CYP3A4 inhibitors increase the concentration of cabozantinib in serum
It may enhance the serum concentration of cabozantinib
MRP2 inhibitors increase the concentration of cabozantinib in serum
Tipranavir may enhance the therapeutic concentration of cabozantinib
rifabutin: they may diminish the serum concentration of cabozantinib
Adverse drug reactions:
Frequency defined
>10%
Increased ALT
increased AST
increased alkaline phosphatase
Hyperbilirubinemia
Diarrhea
Stomatitis
Palmar-Plantar Erythrodysesthesia Syndrome
rash
dry skin
alopecia
erythema
oral pain
constipation
abdominal pain
vomiting
dysphagia
dyspepsia
1-10%
Hypotension
Hyperkeratosis
folliculitis
acne
blister
abnormal hair growth
skin exfoliation
skin hypopigmentation
venous thromboembolism
arterial thromboembolism
atrial fibrillation
Hemorrhoids
GI perforation
GI fistula
GI hemorrhage
pancreatitis
fissure
anal inflammation
cheilitis
0.1-1%
Angina pectoris
Esophagitis
supraventricular tachycardia
Amenorrhea
shortened activated partial thromboplastin time
Frequency not defined
QT interval prolongation
Hemorrhage
Pregnancy warnings:
Breastfeeding warnings:
Pregnancy Categories:
Cabozantinib is a drug from the anti-cancer class. It treats a variety of cancers, including kidney, liver, and thyroid.
It belongs to a class of tyrosine kinase inhibitors that works by retarding or ceasing the cancerous cell growth.
The patient information leaflet contains the advice required by the patients for the dose regimen. It is available with the pharmacist.
Take the medication once daily through the mouth. Don’t take this medicine with meals and only on an empty stomach. Take it before 2 hours or after 1 hour of taking the meal.
Take plenty of water with it. Avoid the consumption of grapefruit or its juice as it increases side effects when taken with medicine.
Do not tamper with or break the solid dose of medicine.
The dose is related to your previous medical condition; discuss it with your physician if you suffer from any disease.
Side effects during the treatment may include nausea, dizziness, diarrhea, mouth ulcers, vomiting, stomach pain, constipation, weakness, tiredness, and weight loss. If the effects get worsen, immediately consult your doctor.
Cabozantinib rarely causes any side effects that may be fatal or serious, like a peptic ulcer or bleeding.
It would be best to always inform your doctor about any minor or significant discomfort after taking the medication. If you have any previous allergies, tell them also to your doctor.
Avoid encountering the people having the infection.
To check on a missed dose, you must take the amount as soon as you remember and should not double the dose if the skipped dose is near to the next dose.
Store the medication at room temperature and away from sunlight/moisture. Keep the product away from pets and children.
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