cadexomer iodine

Action and Spectrum

Actions and Spectrum 

cadexomer, the drug’s polymer component, has the capacity to absorb surplus wound exudate. Exudate is the fluid that is secreted from the wound.  

Broad-spectrum antibacterial properties of iodine make it effective against a variety of pathogens, including bacteria, fungus, and some viruses.

Drug Interaction

Adverse Reaction

Frequency not defined  

Redness or swelling at application site 

Transient slight or moderate pain 

Black Box Warning

Black Box Warning 

None  

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• cadexomer iodine should not be used in individuals with a known hypersensitivity or allergy to iodine or any other product components. 

Caution: 

• Caution should be exercised when using cadexomer iodine in individuals with pre-existing thyroid dysfunction or those at risk of iodine-related complications.  
• The use of cadexomer iodine during pregnancy and breastfeeding should be done with caution. 
• Individuals with impaired renal function may be at a higher risk of iodine-related complications due to reduced clearance of iodine from the body.

Pregnancy / Lactation

Pregnancy warnings:     

Pregnancy category: N/A 

Lactation: stop breastfeeding while using this drug  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

cadexomer iodine releases iodine gradually when it meets wound exudate. The released iodine acts as a broad-spectrum antimicrobial agent, targeting bacteria, fungi, and some viruses present in the wound bed.  

iodine disrupts the microbial cell membrane and inhibits various metabolic processes, leading to the destruction of microorganisms. 

Pharmacodynamics 

cadexomer iodine promotes the formation of a moist wound environment. The cadexomer component of the medication absorbs excess wound exudate, helping to maintain an optimal moisture balance in the wound bed.  

A moist environment supports the migration of cells involved in wound healing, such as fibroblasts and epithelial cells.  

Pharmacokinetics 

Absorption   

cadexomer iodine is primarily intended for external use on wounds, and its absorption through intact skin is minimal.  

Distribution 

cadexomer iodine is distributed throughout the body via the bloodstream.  

cadexomer iodine is predominantly used topically, systemic distribution is minimal. 

Metabolism 

cadexomer iodine does not undergo significant metabolism in the body.  

Elimination and excretion 

The elimination of iodine occurs primarily through the kidneys in the form of iodide ions. 

Adminstartion

Administration 

cadexomer iodine is typically administered topically for wound management.   

Apply enough cadexomer iodine gel directly to the wound.  

Patient Information Leaflet

Patient information leaflet 

Generic Name: cadexomer iodine 

Why do we use cadexomer iodine? 

The treatment of chronic wounds, including as leg ulcers, pressure ulcers, and diabetic foot ulcers, typically involves the use of cadexomer iodine.   

cadexomer iodine can be used in the management of traumatic wounds, such as cuts, abrasions, or surgical wounds.  

cadexomer iodine is effective in managing infected wounds or wounds at risk of infection.