Study Finds Birth Hypoxia May Increase ADHD Likelihood
January 27, 2026
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Brand Name :
Not applicable
Synonyms :
3,4-Dihydroxycinnamic acid
Class :
Herbal Analgesic
Brand Name :
Not applicable
Synonyms :
3,4-Dihydroxycinnamic acid
Class :
Herbal Analgesic
Dosage Forms & Strengths
Liquid/ solid (oral)
5 mg/kg
10 mg/kg
25 mg/kg
Indicated for Neuro-degenerative Disorder (Off label use):
It is shown that the oral dose of 50 mg/kg of hydrocaffeic acid is efficient in attenuating tissue damage
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
caffeic acid when combined with acyclovir results in more adverse effects
caffeic acid when combined with cidofovir results in more adverse effects
caffeic acid when combined with ciprofloxacin results in more adverse effects
caffeic acid when combined with zidovudine results in more adverse effects
caffeic acid when combined with famotidine results in more adverse effects
caffeic acid when combined with ranitidine results in more adverse effects
Action and Spectrum
It is present in variety of plants, coffee, and tea. The supplements help in the reduction of weight, improve the athletic performance, improves tiredness from exercise.
Frequency not defined
GI irritant
Kidney irritant
Insomnia
Nausea
Blackbox warning
It causes trouble to sleep. The Global Agency for Research classified it as a probable Group 2B carcinogen despite the absence of direct evidence of carcinogenicity in humans and the possibility of danger from animal research.
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy categories:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology
It reduces the effect of ultraviolet radiation-induced local immune suppression by blocking the production of interleukines-10 and disrupting the cytokine cascade. It suggests therapeutic promise as a defense against the damaging effects of radiation due to its interference with transcription factors and mitogen activated protein kinase signal transduction pathways. It also inhibits dinoprostone and cyclooxygenase enzyme expression, which prevents Ultraviolet B-induced skin carcinogenesis.
Pharmacodynamics
HeLa and ME-180 cancer cells’ mitochondrial membrane potential is changed by the therapy, which also raises levels of reactive oxygen species and lipid peroxidative indicators. The observation of apoptotic morphological alterations lends credence to the theory that it’s pro-oxidant characteristic is how it fights cancer.
Pharmacokinetics
Absorption
It is absorbed via the digestive tract after oral ingestion.
Distribution
It is absorbed and then distributed throughout the body and other tissues.
Metabolism
It undergoes hepatic metabolism. The molecular structure of the substance is altered by the liver’s function.
Elimination/Excretion
The body excretes caffeic acid metabolites, mostly through the urine.
Administration
Caffeic acid-containing skincare products, such creams, and lotions, provide precise skin absorption when applied topically.
Patient information leaflet
Generic Name: caffeic acid
Pronounced: ka-fee-ik acid
Why do we use caffeic acid?
Caffeic acid acts as anti-inflammatory, antioxidant, and anticancer effects which is present in coffee. Studies demonstrate that it works well against hepatocarcinoma.
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