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Brand Name :
Rolaids Regular Strength Liquid, Rolaids Ultra Strength, Rolaids Extra Strength, Rolaids Regular Strength
Synonyms :
calcium carbonate/magnesium hydroxide
Class :
Antacid, Combos
Brand Name :
Rolaids Regular Strength Liquid, Rolaids Ultra Strength, Rolaids Extra Strength, Rolaids Regular Strength
Synonyms :
calcium carbonate/magnesium hydroxide
Class :
Antacid, Combos
Dosage Forms & Strengths
Suspension
(400mg/135mg)/5ml
(calcium carbonate/magnesium hydroxide)/5ml
(1000mg/200mg)/5ml
(calcium carbonate/magnesium hydroxide)/5ml
(550mg/110mg)/5ml
(calcium carbonate/magnesium hydroxide)/5ml
Tablet
550mg/110mg (calcium carbonate/magnesium hydroxide)
1000mg/200mg (calcium carbonate/magnesium hydroxide)
675mg/135mg (calcium carbonate/magnesium hydroxide)
Antacid: take a dose of 800 to 3000 mg of calcium carbonate orally as needed
Chew 2 to 4 tablets orally as needed
Take suspension orally up to 10-20 ml as needed
Not more than around 7 g of calcium carbonate daily
Dosing Considerations
For calcium carbonate
400 mg equivalent to 160 mg calcium
550 mg equivalent to 220 mg calcium
675 mg equivalent to 270 mg calcium
1000 mg equivalent to 400 mg calcium
For magnesium hydroxide
110 mg equivalent to 45 mg magnesium
135 mg equivalent to 55 mg magnesium
200 mg equivalent to 85 mg magnesium
Administration
Do not take drugs whose absorption is affected by antacids inside 1 hour from intake
Chew the tablets properly
Shake the suspension well prior to use and protect from freezing
Safety and efficacy not determined
Refer to adult dosing
Actions and Spectrum
calcium carbonate is an antacid and a calcium supplement. It works by neutralizing excess stomach acid, providing relief from conditions like acid indigestion, heartburn, and sour stomach. magnesium hydroxide is primarily used as an antacid and laxative. It works by neutralizing stomach acid, like calcium carbonate.
Frequency not defined
Vomiting
Muscle weakness
Hypotension
Electrolyte imbalance
Parageusia
Respiratory depression
Abdominal cramps
Nausea
Diarrhea
Constipation
For calcium carbonate
Hypercalcemia
Acid rebound
Flatulence
Vomiting
Hypophosphatemia
Anorexia
Xerostomia
Milk-alkali syndrome
Nausea
Constipation
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: C (for calcium carbonate); B (for magnesium hydroxide)
Lactation: both drugs are present in human breast milk, and it is safe to use
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
calcium carbonate is source of calcium supplement. It provides a source of elemental calcium, which is essential for various physiological functions, including bone health, nerve function, muscle contraction, and blood clotting. magnesium hydroxide can act as an osmotic laxative. It draws water into the intestines, softening the stool and promoting bowel movements.
Pharmacodynamics
calcium carbonate/magnesium hydroxide has the potential to affect the acid-base balance in the body due to their neutralizing action on stomach acid.
Pharmacokinetics
Absorption
calcium carbonate is partially ionized in the stomach in the presence of gastric acid.
magnesium hydroxide is poorly absorbed from the gastrointestinal track.
Distribution
calcium carbonate/magnesium hydroxide both distributed throughout the body.
Metabolism
calcium carbonate is not significantly metabolized within the body.
magnesium hydroxide undergoes limited metabolism in the body.
Elimination and excretion
calcium carbonate is mainly excreted in the feces.
magnesium hydroxide is excreted through the kidneys.
Administration
calcium carbonate/magnesium hydroxide is administered orally in various forms, such as tablets, capsules, suspensions, chewable tablets.
Patient information leaflet
Generic Name: calcium carbonate/magnesium hydroxide
Why do we use calcium carbonate/ magnesium hydroxide?
calcium carbonate/magnesium hydroxide are used to provide relief from acid indigestion and heartburn. It is also used to relieve symptoms of sour stomach, which is often associated with an upset stomach, bloating, and a feeling of discomfort.
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