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Brand Name :
N/A
Synonyms :
N/A
Class :
NEP inhibitor/antihypertensive agents
Brand Name :
N/A
Synonyms :
N/A
Class :
NEP inhibitor/antihypertensive agents
Dosage Forms & Strengths
Capsules
5mg
50mg
100mg
Dosage Forms & Strengths
Safety and efficacy study is not available
Refer to adult dosing
the hypotensive activity of candoxatril may be increased
the hypotensive activity of candoxatril may be increased
the therapeutic activity of candoxatril may be reduced
Actions and Spectrum
Two enzymes called neutral endopeptidase and Acetylcholine esterase inhibitors, which are involved in breaking down proteins, can be blocked by candoxatril. This allows levels of natriuretic peptides, which have blood vessel-widening and tissue-protecting effects, to increase.
Frequency not defined
Angioedema
Headache
Vertigo
Dizziness
Black Box Warning
Do not operate machinery or drive vehicles, as the drug is known to cause dizziness.
Contraindication/Caution:
Contraindication:
Hypersensitivity
Pregnancy consideration:
USFDA pregnancy category: Not assigned
Lactation:
Data about the excretion of candoxatril into human milk is not known
Pregnancy category:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
<b>Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology
It is a medication that transforms into candoxatrilat, a substance that blocks the activity of a certain enzyme. Studies in animals with high blood pressure have shown that candoxatril can effectively reduce it.
Pharmacodynamics
It inhibits the neutral endopeptidases, including ACE, thereby preserving natriuretic peptides. These peptides possess vasodilatory and tissue-protecting abilities, contributing to their therapeutic potential.
Pharmacokinetics
Absorption
It is absorbed in the gastrointestinal tract
Distribution
Limited information available
Metabolism
It undergoes hydrolysis to form a prodrug candoxatrilat
Elimination/Excretion
It is excreted through kidneys.
Administration
It is administered orally in the form of tablets
Patient information leaflet
Generic Name: candoxatril
Why do we use candoxatril?
Candoxatril inhibits neutral endopeptidases. It is used to treat chronic heart failure and hypertension. This drug’s clinical trials have been discontinued.
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