candoxatril

Action and Spectrum

Actions and Spectrum 

Two enzymes called neutral endopeptidase and Acetylcholine esterase inhibitors, which are involved in breaking down proteins, can be blocked by candoxatril. This allows levels of natriuretic peptides, which have blood vessel-widening and tissue-protecting effects, to increase. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Angioedema 

Headache 

Vertigo 

Dizziness 

Black Box Warning

Black Box Warning 

Do not operate machinery or drive vehicles, as the drug is known to cause dizziness. 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

Hypersensitivity 

Pregnancy / Lactation

Pregnancy consideration:  

USFDA pregnancy category: Not assigned 

Lactation:  

Data about the excretion of candoxatril into human milk is not known 

Pregnancy category:  

Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester. 

<b>Category B: There was a lack of studies on pregnant women and no evidence of risk to the fetus in animal experiments.   

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology 

It is a medication that transforms into candoxatrilat, a substance that blocks the activity of a certain enzyme. Studies in animals with high blood pressure have shown that candoxatril can effectively reduce it. 

Pharmacodynamics 

It inhibits the neutral endopeptidases, including ACE, thereby preserving natriuretic peptides. These peptides possess vasodilatory and tissue-protecting abilities, contributing to their therapeutic potential. 

Pharmacokinetics 

Absorption 

It is absorbed in the gastrointestinal tract 

Distribution 

Limited information available 

Metabolism 

It undergoes hydrolysis to form a prodrug candoxatrilat 

Elimination/Excretion 

It is excreted through kidneys. 

Adminstartion

Administration 

It is administered orally in the form of tablets 

Patient Information Leaflet

Patient information leaflet 

Generic Name: candoxatril 

Why do we use candoxatril? 

Candoxatril inhibits neutral endopeptidases. It is used to treat chronic heart failure and hypertension. This drug’s clinical trials have been discontinued.