carbinoxamine

medtigo

carbinoxamine

Brand Name :

Karbinal ER, Histex PD, Pediox, Pediatex, Ryvent

Synonyms :

carbinoxamine

Class :

Antihistamines, Ethanolamine Derivatives

Action and Spectrum

Actions and Spectrum:

carbinoxamine is a first-generation antihistamine that blocks histamine receptors in the body. Histamine is a chemical released by cells in response to an allergic reaction, and it can cause symptoms such as itching, sneezing, runny nose, and watery eyes.
carbinoxamine’s mechanism of action involves blocking histamine H1 receptors in the body, which helps reduce allergy symptoms. In addition to blocking H1 receptors, carbinoxamine also has some anticholinergic activity, meaning it can block the action of the neurotransmitter acetylcholine in the body. This can help to reduce symptoms such as nausea, vomiting, and motion sickness.
The spectrum of carbinoxamine activity includes treating seasonal and perennial allergic rhinitis, conjunctivitis, and dermatitis. It is also used to relieve symptoms associated with the common cold, such as runny nose and sneezing. carbinoxamine may also relieve itching and hives caused by allergic reactions and prevent motion sickness.

Dosing & Uses

Drug Interaction

Adverse Reaction

Frequency not defined

Muscular weakness

Dizziness

Lassitude

Disturbed coordination

Sedation ranging from mild drowsiness to deep sleep

Muscular weakness

Anorexia

Nausea

Vomiting

Diarrhea

Constipation

Epigastric distress

Pancytopenia

Urinary retention

Vertigo

Blurred vision

Insomnia

Dysuria

Impotence

Visual disturbances

Diplopia; tinnitus

Acute labyrinthitis

Nervousness

Facial dyskinesia

Irritability

Tightness of the chest

Wheezing

Sweating

Toxic psychosis

Faintness

Agranulocytosis

Leukopenia

Headache

Chills

Thickening of bronchial secretions

Tremors

Nasal stuffiness

Early menses

Paresthesia

Hemolytic anemia

Thrombocytopenia

Black Box Warning

Contraindication / Caution

Contraindications/caution:

Contraindications:

Hypersensitivity: carbinoxamine should not be used in individuals with known hypersensitivity or allergy to the medication or its components
Newborns and premature infants: carbinoxamine is not recommended for use in newborns and premature infants.
Respiratory depression: carbinoxamine may cause respiratory depression, especially in patients with chronic obstructive pulmonary disease (COPD), asthma, or other respiratory disorders
Glaucoma: carbinoxamine should be used cautiously in patients with glaucoma, as it can increase intraocular pressure.
Urinary retention: carbinoxamine may cause urinary retention, especially in patients with an enlarged prostate or other urinary tract conditions

Caution:

Sedation: carbinoxamine may cause drowsiness and impair your ability to operate machinery or drive a car. You should avoid using alcohol or other sedatives while taking carbinoxamine
Elderly patients: Older adults may be more sensitive to the sedative effects of carbinoxamine and may be at higher risk for falls or other adverse effects
Children: carbinoxamine should not be used in children under two years unless directed by a healthcare provider
Renal or hepatic impairment: carbinoxamine should be used cautiously in patients with renal or hepatic impairment. The medication may accumulate in the body and increase the risk of adverse effects
Cardiovascular disease: carbinoxamine may cause arrhythmias, especially in patients with pre-existing cardiovascular disease
Epilepsy: carbinoxamine may lower the seizure threshold, so it should be used cautiously in patients with epilepsy
Pregnancy and breast-feeding: carbinoxamine should only be used during pregnancy or breast-feeding if the potential benefits outweigh the risks, as the medication can cross the placenta and enter breast milk

Pregnancy / Lactation

Pregnancy consideration: Insufficient data available

Lactation: Excretion of the drug in human breast milk is unknown

Pregnancy category:

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.

Category N: There is no data available for the drug under this category

Pharmacology

Pharmacology:

carbinoxamine is an antihistamine medication primarily used to treat allergic conditions such as hay fever, allergic rhinitis, and hives. It works by blocking the action of histamine, a substance released in response to an allergic reaction.

Pharmacodynamics:

carbinoxamine exerts its antihistaminic effects by competitively blocking H1 receptors in the body. It also possesses anticholinergic properties, which may contribute to its therapeutic effects.

Pharmacokinetics:

Absorption

carbinoxamine is well-absorbed after oral administration. The medication can also be administered intramuscularly or intravenously.

Distribution

carbinoxamine is distributed throughout the body, including the central nervous system. It can cross the blood-brain barrier and the placenta.

carbinoxamine

No data available for drug.

DRUG INTERACTION

carbinoxamine

&

carbinoxamine +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

carbinoxamine

No data available for drug.

DRUG INTERACTION

carbinoxamine

&

carbinoxamine +

Contraindicated

Serious Use Alternative

Monitor Closely

Minor

medtigo

carbinoxamine

Brand Name :

Synonyms :

Class :

Action and Spectrum

Dosing & Uses

Drug Interaction

Adverse Reaction

Black Box Warning

Contraindication / Caution

Pregnancy / Lactation

Pharmacology