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December 14, 2025
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Brand Name :
Optase, TBC, Xenaderm, Granulex, Allandem-T, Revina NLT
Synonyms :
Agaliya oil, Bimayou, castor oil, Castorbean oil, Cataputia major oil, Cataputia minor oil; Balsam (peru) oil, Balsam of Peru essential oil, Balsam Peru, Balsam Peru oil, Balsam peru volatile oil, Balsam-of-peru oil; Enzyme Protéolytique, Proteinase, Protéinase, Proteolytic Enzyme, Tripsin, Tripsina, Trypsine
Class :
Gastrointestinal agent, Laxative; Myroxylon balsamum pereirae tree oily sap, resin, Antiseptic; Hydrolases, Acting on peptide bonds, Serine endopeptidases
Brand Name :
Optase, TBC, Xenaderm, Granulex, Allandem-T, Revina NLT
Synonyms :
Agaliya oil, Bimayou, castor oil, Castorbean oil, Cataputia major oil, Cataputia minor oil; Balsam (peru) oil, Balsam of Peru essential oil, Balsam Peru, Balsam Peru oil, Balsam peru volatile oil, Balsam-of-peru oil; Enzyme Protéolytique, Proteinase, Protéinase, Proteolytic Enzyme, Tripsin, Tripsina, Trypsine
Class :
Gastrointestinal agent, Laxative; Myroxylon balsamum pereirae tree oily sap, resin, Antiseptic; Hydrolases, Acting on peptide bonds, Serine endopeptidases
Dosage Forms & Strengths
Topical (protectant)
650 mg/72.5 mg/0.1 mg
788 mg/87 mg/90 units/g
788 mg/87 mg/ 0.12 mg/g
Safety and efficacy are not seen in pediatrics
Refer to the adult dosing
Actions and Spectrum:
Actions:
This ointment has trypsin, Peru balsam, and castor oil. Its job is to treat skin wounds and help heal. It makes blood vessels more active. It removes damaged tissue, too. The castor oil also lubricates the wound. This covers and protects the tissue.
Spectrum:
This blend contains three key elements: castor oil, Peru balsam, and trypsin. Castor oil helps with digestion by keeping bowels regular. It also gives the product its smooth texture. Peru balsam comes from the Myroxylon tree. Its special powers fight germs and heal wounds. Trypsin is an enzyme that breaks down proteins. It removes dead tissue to help wounds heal faster. By combining these ingredients, the product tackles many wound care and skin health issues. It promotes healing, kills germs, and nourishes skin all at once.
Black Box Warning:
Discuss trypsin, balsam Peru, and castor oil ointment use with all healthcare providers like doctors, nurses, pharmacists, dentists. If accidentally swallowed, get urgent medical help – it could be harmful. If pregnant or planning pregnancy, ask your doctor about benefits and risks of using the ointment. Also consult your doctor if breastfeeding to understand any potential baby risks. Communicating regularly with your healthcare team ensures safe, informed medication use.
Only apply externally – avoid eye contact. Do not use on fresh arterial clots.
Frequency not defined
Serious infection (chills/fever, fast heart beat, hyperventilation, weakness, warm skin)
Serious allergic reactions (itching, burning, rash, swelling, trouble breathing, dizziness)
Unusual redness or bleeding or irritation of wound
Stinging at area of application
Black Box Warning:
Discuss trypsin, balsam Peru, and castor oil ointment use with all healthcare providers like doctors, nurses, pharmacists, dentists. If accidentally swallowed, get urgent medical help – it could be harmful. If pregnant or planning pregnancy, ask your doctor about benefits and risks of using the ointment. Also consult your doctor if breastfeeding to understand any potential baby risks. Communicating regularly with your healthcare team ensures safe, informed medication use.
Only apply externally – avoid eye contact. Do not use on fresh arterial clots.
Contraindication/Caution:
Contraindications
Cautions
Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Trypsin helps remove dead tissue from wounds. Balsam Peru makes blood flow better around the wound. It may also kill some germs. Castor oil helps heal the skin, covers the wound, and reduces pain. Together, these work on different parts of healing. They take off old tissue, make blood move, and ease pain. Mixing them gives a full way to make wounds get better from many sides.
Pharmacodynamics:
The pharmacodynamics involve actions of each component. Castor oil assists epithelialization and forms a protective barrier, reducing wound-related pain. It supports tissue repair overall. Peru balsam aids circulation at the wound site. It exhibits bactericidal effects, enhancing blood flow and preventing infection. Trypsin, an enzyme, helps debride necrotic tissue. This creates a cleaner wound environment, promoting healing. Together, these components provide a comprehensive wound care approach. This incorporates tissue repair, circulation stimulation, and infection prevention. It facilitates effective skin health and wound management.
Pharmacokinetics:
Limited data is available
Administration:
When using the ointment made of trypsin, balsam Peru, and castor oil, follow your doctor’s instructions carefully. Read all information and guidelines thoroughly. Don’t swallow the ointment. Apply only on your skin. Keep it away from your eyes, nose, and mouth to prevent irritation. Before applying, clean and dry the affected area well. Wash hands before and after using the ointment, whether applying on hands or other body parts. Your doctor may advise using a bandage or dressing over the treated area. Use a thin layer of ointment as instructed.
Ointments, creams, or topical solutions containing castor oil, Peru balsam, and trypsin serve various therapeutic purposes. When applied topically, the right dose reaches the affected skin area. Castor oil acts as a laxative, Peru balsam has antiseptic and wound-healing properties, and trypsin breaks down proteins. For wound care, this combination helps remove dead tissue and promotes healing. Follow your healthcare provider’s dosage instructions strictly. Watch for allergic reactions or side effects, and consult a doctor if needed. Overall, this versatile combination addresses medical conditions like skin issues and wound care effectively.
Patient information leaflet
Generic Name: castor oil/peru balsam/trypsin
Pronounced: kas-ter oil/puh-roo bawl-suhm/trip-sin
Why do we use castor oil/peru balsam/trypsin?
Castor oil promotes bowel movements. It relieves constipation through its laxative properties. Myroxylon tree produces Peru balsam. This substance possesses antiseptic and wound-healing qualities, suitable for skin conditions in topical formulations. Trypsin, an enzyme aiding protein breakdown, helps remove dead tissue and supports wound healing. It is commonly used with other substances in wound care and topicals. Formulated for medical or cosmetic use, such combinations leverage each ingredient’s unique properties to address specific conditions effectively. They may come as ointments, creams, or topical solutions.
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