cefsulodin

Action and Spectrum

Actions and Spectrum 

Actions: 

cefsulodin works by inhibiting the synthesis of bacterial cell walls. 

It interferes with forming the peptidoglycan layer, of bacterial cell walls, leading to cell wall weakening and eventual cell death. 

Spectrum: 

cefsulodin has a limited spectrum of activity and is primarily effective against Gram-negative bacteria. 

It is beneficial against certain types of Gram-negative rods (Bacilli). 

cefsulodin is often used for its activity against members of the Enterobacteriaceae family, such as Klebsiella and Enterobacter species. 

Drug Interaction

Adverse Reaction

>10% 

Pseudomembranous colitis 

Frequency not defined 

Diarrhea 

Vomiting 

Nausea 

Nephrotoxicity 

CNS toxicity 

Convulsions 

Hepatic dysfunction 

Pain at the site of injection 

Thrombophlebitis 

Convulsions 

Nephrotoxicity 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Hypersensitivity 

Caution: 

• Renal impairment 
• Gastrointestinal disorders 
• Superinfection 
• Allergic reactions 
• Seizures 
• Drug interactions 
• Pregnancy 
• Breastfeeding 
• Drug interactions 
• Blood clotting disorders 

Pregnancy / Lactation

Pregnancy consideration:  

Pregnancy Category: A 

Breastfeeding warnings:  

cefsulodin is excreted in the breastmilk in the least amount. 

Pregnancy category: 

Category A: Well-controlled and satisfactory studies show no risk to the fetus in the initial or later trimester. 

<b>Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 

Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.    

Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology:  

• cefsulodin is a beta-lactam antibiotic, belonging to the cephalosporin class. 
• Its primary mechanism of action is to inhibit bacterial cell wall synthesis, a crucial structural component for bacterial survival. 

Pharmacodynamics: 

• cefsulodin binds to and inhibits enzymes known as penicillin-binding proteins (PBPs) in the bacterial cell wall. 
• Inhibition of PBPs interferes with the cross-linking of peptidoglycan strands in the cell wall, weakening its structure. 

Pharmacokinetics: 

Absorption 

cefsulodin is administered intravenously, and it achieves high blood levels rapidly. 

Distribution 

It distributes widely in body tissues and fluids but may not penetrate the central nervous system effectively.  

Metabolism 

cefsulodin undergoes minimal metabolism in the body. 

Elimination and Excretion 

The drug gets primarily excreted through the kidneys. 

Adminstartion

Administration: 

cefsulodin is administered under the supervision of a healthcare provider, usually in a hospital or clinical setting. The specific dosage of cefsulodin will depend on the type and severity of the infection, the patient’s weight, and other factors. The healthcare provider will calculate the appropriate dosage. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: cefsulodin 

Pronounced as: sef-su-lo-din 

Why do we use cefsulodin? 

cefsulodin is an antibiotic primarily used for: 

• Treating Infections: It treats various bacterial infections, especially those caused by Gram-negative bacteria. 
• Microbiology: cefsulodin is used in microbiology laboratories as a selective agent to isolate specific bacterial strains for research and identification purposes. 
• Cystic Fibrosis: It has been used to treat lung infections in individuals with cystic fibrosis.