choline salicylate

Action and Spectrum

Actions and Spectrum 

Choline salicylate a combination of choline magnesium salicylate and magnesium salicylate which is a non-steroidal anti-inflammatory drug (NSAID) used to relieve mild to moderate pain including dental and oral discomfort. It inhibits the production of prostaglandins and prevents pain and inflammation. 

Drug Interaction

Adverse Reaction

Frequency not defined 

weakness 

haemolytic anaemia 

hypersensitivity reactions 

dyspnoea 

skin eruptions 

Reye’s syndrome 

fatigue 

GI disorders 

local irritation (rectally) 

Black Box Warning

Black Box Warning: 

None 

Contraindication / Caution

Contraindication/Caution: 

Choline salicylate can cause allergic reactions, asthma, peptic ulcers, and gastrointestinal bleeding. 

Pregnancy / Lactation

Pregnancy consideration:  

US FDA pregnancy category: Not assigned. 

Lactation:   

Excreted into human milk: Not known. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.    
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.    
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.    
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

Pharmacodynamics: 

Choline salicylate acts by inhibiting the cyclooxygenase (COX) enzyme. This leads to decreased prostaglandin production reducing inflammation at the application site. It reduces pain, swelling, and redness associated with dental pain, mouth ulcers, and gingivitis. Choline salicylate also has analgesic effects by reducing pain sensation and exerting an antipyretic effect by reducing prostaglandins responsible for fever. 

Pharmacokinetics: 

Absorption 

It is well absorbed. 

Distribution 

It is distributed throughout the body 

Metabolism 

It undergoes hydrolysis and produces free salicylate.  

Elimination and Excretion 

It is excreted through urine and feces.  

Adminstartion

Administration: 

It is available in oral gels, mouthwashes, and ointments. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: choline salicylate 

Why do we use choline salicylate? 

Choline salicylate act as analgesic and anti-inflammatory by treating the oral pain and inflammation. It is also effective in treating mouth ulcers and minor injuries in children.