- March 15, 2022
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Brand Name :
APO-Cimetidine, DOM-Cimetidine, Cimetidine Acid Reducer
Synonyms :
cimetidine
Class :
Drugs for peptic ulcer & H2 receptor blockers
Dosage Forms & Strengths
Solution, Oral (Hydrochloride):
400 mg/6.67ml
300 mg/5ml
Tablet, Oral:
200mg
300mg
400mg
800mg
400
mg
Orally
4 times a day
for 12 weeks
or
800 mg orally twice a day for 12 weeks
200
mg
Orally
3 times a day
or
300 to 400 mg orally twice a day
Dosage Forms & Strengths
Solution, Oral (Hydrochloride):
400 mg/6.67ml
300 mg/5ml
Tablet, Oral:
200mg
300mg
400mg
800mg
Children 5 to 16 years:
20 - 40
mg/kg
Orally
daily in 3 to 4 divided doses for 4 to 8 weeks
(Do not exceed 300mg/dose)
Maintenance dose: 5 to 6 mg/kg orally once a day at bedtime
Children and adolescents:
30 - 40
mg/kg
Orally
daily in 4 divided doses
Gastric ulcer:
Children and adolescents >16 years: 800 mg orally at bedtime for up to 8 weeks
Sour stomach/Heartburn:
200 g orally daily up to 30 minutes prior to eating foods causing heartburn.
may decrease the serum concentration
may decrease the serum concentration and decrease in the efficacy
may diminish the serum concentration
may enhance the serum concentration of metformin
It may enhance the effect when combined with sufentanil by diminishing metabolism
when both drugs are combined, there may be an increased level or effect of romidepsin by affecting hepatic or intestinal enzyme cyp3a4 metabolism
it increases the effect of diphenoxylate by decreasing the metabolism
relugolix/estradiol/norethindrone
it enhances by affecting the hepatic enzyme CYP3A4 metabolism
may have an increased risk of rhabdomyolysis & myoglobinuria when combined with cimetidine
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of active metabolites of roflumilast in the serum
l-methylfolate-pyridoxal 5′-phosphate-methylcobalamine
may decrease the serum concentration of multivitamins
may decrease the serum concentration of minerals
may decrease the serum concentration of minerals
may decrease the serum concentration of minerals
may decrease the serum concentration of minerals
may decrease the serum concentration of minerals
may decrease the serum concentration of minerals
it increases the concentration of alfentanil in the serum
may enhance the serum concentration when combined with calcium channel blockers
may enhance the serum concentration when combined with calcium channel blockers
may enhance the serum concentration when combined with calcium channel blockers
may enhance the serum concentration when combined with calcium channel blockers
may enhance the serum concentration when combined with calcium channel blockers
may enhance the serum concentration when combined with lidocaine
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
cimetidine can impact the hepatic/intestinal enzyme CYP3A4 metabolism, leading to an elevation in the level or potency of intranasal midazolam
it may diminish the metabolism when combined with azelastine
It may enhance the effect when combined with tafamidis meglumine
cimetidine has the potential to reduce the rate of excretion of idebenone, leading to an elevation in levels of serum
When bacampicillin is combined with cimetidine, bacampicillin absorption and blood levels decrease by stomach acid reduction.
may reduce the therapeutic effects of cimetidine
when both drugs are combined, there may be an increased effect of cabozantinib by affecting hepatic or intestinal enzyme cyp3a4 metabolism
when both drugs are combined, there may be a decrease in levels of serum concentration and absorption of erlotinib
increases serum level of cabazitaxel by affecting the enzyme CYP3A4
cimetidine may enhance the level and effect of docetaxel by affecting CYP3A4
when both drugs are combined, there may be an increased risk of adverse effects
cimetidine may enhance the level and effect of erdafitinib by affecting CYP3A4
may enhance the plasma concentration of fluorouracil-derived products
it increases the effect or level of palbociclib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it increases the concentration of Norepinephrine Reuptake Inhibitors
it enhances by affecting the hepatic enzyme CYP2D6 metabolism
may enhance the serum concentration
it increases the concentration of metformin in the serum
it increases the effect of sulfamethoxazole by altering hepatic CYP2C9/10 enzyme metabolism
CNS effects have been reported with cimetidine including agitation, delirium, and confusion.
Frequency defined:
1%-10%
Headache
Dizziness
Drowsiness
Gynecomastia
Diarrhea
Frequency not defined:
Increased serum creatinine
Agitation
Anaphylaxis
Decreased white blood cell
Disorientation
Hepatic fibrosis
Anxiety
Hallucination
Hemolytic anemia
Pancytopenia
Urinary retention
Pregnancy consideration: cimetidine falls under pregnancy category B.
Lactation: Not recommended for lactating females as it can be excreted in breast milk.
Pregnancy category:
Patient information leaflet
Generic Name: Cimetidine
Pronounced: sy-me-ti-deen
Why do we use cimetidine?
Cimetidine is an H2 receptor blocker analog. It is used to treat heartburn, acid reflux, and peptic ulcers.
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