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Brand Name :
Stalopam Plus, Nexito Forte, Szetalo Plus, Depran, Petril Plus, Feliz S Plus
Synonyms :
clonazepam/escitalopram oxalate
Class :
Benzodiazepines, Selective serotonin reuptake inhibitor (SSRI)
Brand Name :
Stalopam Plus, Nexito Forte, Szetalo Plus, Depran, Petril Plus, Feliz S Plus
Synonyms :
clonazepam/escitalopram oxalate
Class :
Benzodiazepines, Selective serotonin reuptake inhibitor (SSRI)
Dosage Forms & Strengths
Tablet
0.5mg/10mg
(clonazepam/escitalopram oxalate)
Take one tablet orally once daily
Not determined
Refer to adult dosing
Actions and Spectrum
clonazepam is classified as a benzodiazepine. It acts as a central nervous system depressant and primarily affects the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. It enhances the inhibitory effects of GABA, which results in a calming and sedative effect on the central nervous system.
escitalopram oxalate belongs to selective serotonin reuptake inhibitor (SSRI) class. It works by increasing the levels of the neurotransmitter serotonin in the brain.
Frequency not defined
Memory impairment
Drowsiness
Delayed ejaculation
Nausea
Uncoordinated body movements
Confusion
Tiredness
Anorgasmia
Low sexual desire
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
clonazepam acts as a central nervous system depressant. It primarily enhances the effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain.
escitalopram oxalate works by inhibiting the reuptake of serotonin in the brain. It raised levels of serotonin in the synaptic cleft between neurons, which helps regulate mood and emotions.
Pharmacodynamics
clonazepam binds to specific GABA-A receptors, leading to increased GABA activity. This results in a calming and sedative effect on the central nervous system.
escitalopram oxalate increases the concentration of serotonin, which is a neurotransmitter associated with mood regulation.
Pharmacokinetics
Absorption
clonazepam/escitalopram oxalate is well absorbed when taken orally.
It reaches peak plasma concentrations within hours.
Distribution
clonazepam/escitalopram oxalate is distributed throughout the body.
Metabolism
clonazepam undergoes extensive hepatic metabolism in the liver.
While escitalopram oxalate undergoes minimal metabolism in the liver.
Elimination and excretion
clonazepam/escitalopram oxalate are excreted in the urine.
Administration
clonazepam/escitalopram oxalate is combination drug available in tablet form for oral intake.
Patient information leaflet
Generic Name: clonazepam/escitalopram oxalate
Why do we use clonazepam/escitalopram oxalate?
clonazepam/escitalopram oxalate is a combination drug used in management of anxiety disorders, including generalized anxiety disorder (GAD).
clonazepam/escitalopram oxalate is a combination drug used in the treatment of depression and seizure disorders.
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