clonazepam/escitalopram oxalate

Action and Spectrum

Actions and Spectrum 

clonazepam is classified as a benzodiazepine. It acts as a central nervous system depressant and primarily affects the neurotransmitter gamma-aminobutyric acid (GABA) in the brain. It enhances the inhibitory effects of GABA, which results in a calming and sedative effect on the central nervous system.   

escitalopram oxalate belongs to selective serotonin reuptake inhibitor (SSRI) class. It works by increasing the levels of the neurotransmitter serotonin in the brain.

Drug Interaction

Adverse Reaction

Frequency not defined  

Memory impairment 

Drowsiness 

Delayed ejaculation 

Nausea 

Uncoordinated body movements 

Confusion 

Tiredness 

Anorgasmia  

Low sexual desire 

Black Box Warning

Black Box Warning 

None 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• clonazepam/escitalopram oxalate should not be used in individuals who are hypersensitive or allergic to its components. 

Caution: 

• Caution is advised while using clonazepam to individuals with a history of substance abuse. 
• escitalopram oxalate should be used with caution in individuals at risk of developing serotonin syndrome.  

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

clonazepam acts as a central nervous system depressant. It primarily enhances the effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain.  

escitalopram oxalate works by inhibiting the reuptake of serotonin in the brain. It raised levels of serotonin in the synaptic cleft between neurons, which helps regulate mood and emotions.  

Pharmacodynamics 

clonazepam binds to specific GABA-A receptors, leading to increased GABA activity. This results in a calming and sedative effect on the central nervous system. 

escitalopram oxalate increases the concentration of serotonin, which is a neurotransmitter associated with mood regulation. 

Pharmacokinetics 

Absorption   

clonazepam/escitalopram oxalate is well absorbed when taken orally.  

It reaches peak plasma concentrations within hours. 

Distribution 

clonazepam/escitalopram oxalate is distributed throughout the body. 

Metabolism 

clonazepam undergoes extensive hepatic metabolism in the liver.  

While escitalopram oxalate undergoes minimal metabolism in the liver. 

Elimination and excretion 

clonazepam/escitalopram oxalate are excreted in the urine. 

Adminstartion

Administration 

clonazepam/escitalopram oxalate is combination drug available in tablet form for oral intake. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: clonazepam/escitalopram oxalate 

Why do we use clonazepam/escitalopram oxalate? 

clonazepam/escitalopram oxalate is a combination drug used in management of anxiety disorders, including generalized anxiety disorder (GAD). 

clonazepam/escitalopram oxalate is a combination drug used in the treatment of depression and seizure disorders.