- March 15, 2022
- Newsletter
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Brand Name :
Clozaril, Versacloz
Synonyms :
clozapine
Class :
Antipsychotics, Second Generation
Dosage Forms & Strengths
Tablet
25 mg
50 mg
100 mg
200 mg
Oral suspension
50mg/ml
Take a dose of 12.5 mg orally one time a day; raise the dose up to 25 to 50 mg daily and if well tolerated
To achieve target dose of daily 300 to 450 mg is administered in divided doses by completion of two weeks
It may raise dose one or two times in week up to 100 mg and a daily dose not more than 900 mg
Dosage Modifications
For Coadministration with CYP inhibitors
Strong CYP1A2 inhibitors: Use one-third part of clozapine dose
Moderate or weak CYP1A2 inhibitors: decrease clozapine dose if required
CYP2D6 or CYP3A4 inhibitors: decrease clozapine dose if required
CYP2D6 poor metabolizers: decrease clozapine dose if required
For Coadministration with CYP inducers
Strong CYP3A4 inducers: Coadministration not suggested
Moderate or weak CYP1A2 or CYP3A4 inducers: increase clozapine dose if required
For Renal or hepatic impairment
Decreased dose may be required
Dosing Considerations
Before starting, obtain complete blood count with differential for initial absolute neutrophil count to maintain therapy, absolute neutrophil count must be regularly monitored
Safety and efficacy not determined
Refer to adult dosing
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
may diminish the therapeutic effect of anti-parkinson agents
may diminish the serum concentration of CYP3A4 Inducers
may have an increased constipating effect when combined with clozapine
may have an increased constipating effect when combined with clozapine
may have an increased constipating effect when combined with clozapine
may have an increased constipating effect when combined with clozapine
may have an increased constipating effect when combined with clozapine
may have an increased QTc-prolonging effect when combined with clozapine
may have an increased QTc-prolonging effect when combined with clozapine
may have an increased QTc-prolonging effect when combined with clozapine
may have an increased QTc-prolonging effect when combined with clozapine
may have an increased QTc-prolonging effect when combined with clozapine
clofazimine: they may increase the QTc-prolonging effect of QTc-prolonging Agents
clofazimine: they may increase the QTc-prolonging effect of QTc-prolonging Agents
clofazimine: they may increase the QTc-prolonging effect of QTc-prolonging Agents
