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Brand Name :
vitamin Q10, mitoquinone,
Synonyms :
coenzyme Q10
Class :
Herbals, Cardiovascular
Brand Name :
vitamin Q10, mitoquinone,
Synonyms :
coenzyme Q10
Class :
Herbals, Cardiovascular
Suggested Dosing
CHF:
100 mg orally 2-3 times a day
Action and spectrum:
CoQ10 helps in energy production and antioxidant defense by transferring electrons from complex I and II to complex III in the mitochondrial membrane. CoQ10 protects cells from oxidative damage by neutralizing free radicals and regenerating other antioxidants.
Frequency Not Defined
Appetite decreased
Diarrhea
Elevated LFTs
Nausea
Gastric distress
Blackbox warning:
None
Contraindication/caution:
Coenzyme Q10 (CoQ10) is a natural substance produced in body and available as a dietary supplement. It is safe for most people but there are some contraindications and cautions. Allergies, blood pressure, blood thinners, chemotherapy, liver disease, and diabetes are contraindicated.
Pregnancy category: N/A
Lactation: Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pregnancy warnings:
Pharmacology:
coenzyme Q10 is naturally occurring compound found in all living cells.
Pharmacodynamics:
It helps in production of energy within mitochondria of cells making it a crucial part of the body metabolism. CoQ10 has antioxidant properties that protects cells from oxidative damage.
Pharmacokinetics:
Absorption
It is fat-soluble molecule and is well absorbed.
Distribution
Well distributed
Metabolism
metabolized in the liver through ubiquinone reduction.
Elimination and Excretion
Metabolites are eliminated from body through bile and feces.
Administration:
CoQ10 is available in supplement form and taken orally as capsule, tablet, or liquid forms.
Patient information leaflet
Generic Name: coenzyme Q10
Why do we use coenzyme Q10?
coenzyme Q10 (CoQ10) is a naturally occurring compound that plays crucial role in cellular energy production. It is found in every cell of the body and is particularly abundant in heart, liver, and kidneys.
It treats Leber’s Hereditary Optic Neuropathy, Myocardial preservation for heart surgery, and CHF.
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