- March 15, 2022
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Brand Name :
Colcrys, Gloperba, Mitigare
Synonyms :
colchicine
Class :
Antigout agents
Dosage Forms & Strengths
Capsule
0.6 mg
Tablet
0.6 mg
Dosage Forms & Strengths
Capsule
0.6 mg
Tablet
0.6 mg
may increase the serum concentration of colchicine
may increase the serum concentration of colchicine
may increase the serum concentration of colchicine
may increase the serum concentration of colchicine
may increase the serum concentration of colchicine
may enhance the concentration of serum when combined with colchicine
may enhance the concentration of serum when combined with colchicine
may enhance the concentration of serum when combined with colchicine
may enhance the concentration of serum when combined with colchicine
may enhance the concentration of serum when combined with colchicine
colchicine: they may enhance the serum concentration of CYP3A Inhibitors
colchicine: they may enhance the serum concentration of CYP3A Inhibitors
may enhance the serum concentration of P-glycoprotein/ABCB1 inhibitors
may enhance the serum concentration of CYP3A4 Inhibitors
may enhance the serum concentration of P-glycoprotein/ABCB1 Inhibitors
It may enhance the effect when combined with grapefruit by CYP3A4 metabolism
colchicine and lapatinib increase the effect of each other when used simultaneously
may enhance the myopathic effect of colchicine
may enhance the myopathic effect of colchicine
may enhance the myopathic effect of colchicine
may enhance the myopathic effect of colchicine
may enhance the myopathic effect of colchicine
It may diminish the effect when combined with griseofulvin by CYP3A4 metabolism
it decreases the efficacy of choline C11
it may diminish the excretion rate when combined with gadofosveset, resulting in an enhanced serum level
may intensify the potentially negative effects of HMG-CoA Reductase Inhibitors
Adverse drug reactions
Frequency defined
>10%
vomiting
Diarrhea
abdominal pain
nausea cramping
1-10%
Pharyngolaryngeal pain (2-3%)
Fatigue (1-4%)
Headache (1-2%)
Gout (0-4%)
Frequency Not Defined
Myelosuppression
Neuromuscular toxicity
Post marketing Reports
Sensory motor neuropathy
Alopecia
Purpura
Maculopapular rash
Lactose intolerance
abdominal cramping
abdominal pain
Pregnancy warnings:
AU TGA pregnancy category: D
US FDA pregnancy category: C
Lactation:
Excreted into human milk is known
Pregnancy Categories:
Category A: Satisfactory and well-controlled studies show no risk to the fetus in the first or later trimester.
Category B: No evidence shown of risk to the fetus found in animal reproduction studies, and there are not enough studies on pregnant women
Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for a result in humans must take care of potential risks in pregnant women
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient Information Leaflet
Generic Name: colchicine
Why do we use colchicine?
colchicine, an Antigout agent used to treat gout in and Familial Mediterranean Fever.
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