- March 15, 2022
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Brand Name :
Coly Mycin M, colistimethate sodium
Synonyms :
colistin
Class :
Other, Antibiotics
Brand Name :
Coly Mycin M, colistimethate sodium
Synonyms :
colistin
Class :
Other, Antibiotics
Dosage Forms & Strengths
Injectable powder
150mg per vial
Dosage Forms & Strengths
Injectable powder
150mg per vial
Refer to the adult dosing regimen
Actions and spectrum:
colistin is an antibiotic that belongs to the class of polymyxins. It is used to treat infections which are caused by Gram-ve bacteria, including Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae.
colistin is a last-resort antibiotic and is typically used only when other antibiotics are ineffective or not available. It acts by binding to the bacterial cell membrane and disrupting its structure, leading to bacterial death.
Frequency defined
<1%
Nephrotoxicity
Respiratory tract paralysis
Neurotoxicity
Acute respiratory failure
1-10%
Paresthesia
Tingling of tongue and extremities
Dizziness
Frequency not defined
Vertigo
Anaphylaxis
Slurred speech
Seizures
Contraindication/Caution:
Contraindication:
colistin is contraindicated in patients with a history of hypersensitivity or allergic reaction to colistin or polymyxins. It is also contraindicated in patients with pre-existing renal dysfunction or neurological disorders.
Caution:
Comorbidities:
colistin is an antibiotic and is typically used to treat bacterial infections which are caused by gram-negative bacteria. It is usually reserved for infections that are resistant to other antibiotics.
Patients with comorbidities such as kidney disease or neuromuscular disorders may need dosage adjustments or close monitoring when taking colistin. colistin can cause kidney damage, and patients with kidney disease may be at increased risk.
Pregnancy consideration: Pregnancy Category: C
Lactation: It is not known if colistin is excreted in human milk
Pregnancy category:
Pharmacology:
colistin is an antibiotic that belongs to the polymyxin group of antibiotics. It acts by binding to the bacterial cell membrane, causing the membrane to become more permeable and resulting in leakage of essential cell contents, leading to bacterial cell death. colistin has a broad spectrum of activity against Gram-ve bacteria, including Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. It is usually used to treat multidrug-resistant Gram-negative infections. colistin is not effective against Gram-positive bacteria, fungi, or viruses.
Pharmacodynamics:
colistin is a bactericidal antibiotic that destroys the bacterial cell membrane and causes cell death. It has narrow spectrum of activity and is active against a limited number of Gram-negative bacteria, including Pseudomonas aeruginosa and Acinetobacter baumannii. colistin works by binding to the bacterial cell membrane, causing disruption of the membrane and subsequent leakage of intracellular components, leading to bacterial cell death.
colistin is considered a last-resort antibiotic due to its potential for toxicity and the development of resistant strains of bacteria.
Pharmacokinetics:
Absorption
colistin is not absorbed orally and is not effective when given orally. It is administered either intravenously or by inhalation.
Distribution
colistin has poor penetration into most tissues and is primarily distributed in extracellular fluid. It does not penetrate the blood-brain barrier.
Metabolism
colistin is not metabolized in the body.
Elimination and excretion
colistin is excreted unchanged by the kidneys, and its elimination half-life is about 2-3 hours in patients with normal renal function.
Administration:
colistin is administered through intravenous (IV) injection or inhalation.
For intravenous injection, colistin is usually given slowly over a period of 30-60 minutes. It should not be given as a IV bolus injection.
For inhalation, colistin is administered using a nebulizer creates a very fine mist that can be inhaled into the lungs.
The dosage and duration of colistin treatment based on the severity of the patient’s age and weight, the infection, and other factors.
Patient information leaflet
Generic Name: colistin
Pronounced: (kuh-LISS-tin)
Why do we use colistin?
colistin is an antibiotic that is primarily used to treat infections caused by gram-ve bacteria, such as Pseudomonas aeruginosa and Acinetobacter baumannii. These bacteria are often resistant to other antibiotics, making colistin an important treatment option. colistin is typically reserved for use in the treatment of infections that have not responded to other antibiotics or for infections caused by highly resistant bacteria. It may be used to treat infections of the lungs, bloodstream, urinary tract, and other parts of the body.