cromolyn sodium, intranasal

Action and Spectrum

Actions and Spectrum 

Cromolyn sodium intranasal stabilizes mast cells, which are immune cells involved in the allergic response.  

By preventing the release of certain inflammatory mediators, such as histamine, it helps to reduce the symptoms of allergic rhinitis. 

Drug Interaction

Adverse Reaction

Frequency not defined  

Transient nasal stinging  

Unpleasant taste 

Epistaxis 

Headache 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals who have a known hypersensitivity or allergy to cromolyn sodium or any of its components should not use the medication. 

Caution: 

• Caution should intranasal be exercised in individuals with a history of systemic allergic reactions. 
• Cromolyn sodium intranasal is not intended for the treatment of acute asthma attacks.

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: N/A 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

When exposed to allergens, mast cells release inflammatory mediators, such as histamine, leading to allergic symptoms. 

Cromolyn sodium intranasal stabilizes mast cell membranes, preventing the release of these inflammatory mediators.  

Pharmacodynamics 

Cromolyn sodium intranasal inhibits the degranulation process of mast cells. 

By preventing this degranulation, cromolyn sodium reduces the release of inflammatory mediators. 

Pharmacokinetics 

Absorption   

Cromolyn sodium is absorbed through the nasal mucosa. 

Distribution 

Cromolyn sodium is distributed locally within the nasal tissues. 

Metabolism 

Cromolyn sodium undergoes minimal hepatic metabolism. 

Elimination and excretion 

Cromolyn sodium is excreted by the kidneys. 

Adminstartion

Administration 

Cromolyn sodium is administered intranasally, in form of nasal spray. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: cromolyn sodium, intranasal 

Why do we use cromolyn sodium, intranasal? 

Cromolyn sodium intranasal is commonly used to prevent and manage symptoms associated with seasonal allergies. 

Cromolyn sodium intranasal can help reduce nasal congestion associated with allergic rhinitis.