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Brand Name :
Nasal Crom
Synonyms :
cromolyn sodium, intranasal
Class :
Allergy, Mast Cell Stabilizers
Dosage Forms & Strengths
Spray
5.2mg/spray
Put 1 spray in each nostril every 6 to 8 hours and it may raise to 6 times in a day
Dosage Forms & Strengths
Spray
5.2mg/spray
For <2 years old: Safety and efficacy not determined
For ≥2 years old:
Put 1 spray in each nostril every 6 to 8 hours and it may raise to 6 times in a day
Refer to adult dosing
Actions and Spectrum
Cromolyn sodium intranasal stabilizes mast cells, which are immune cells involved in the allergic response.
By preventing the release of certain inflammatory mediators, such as histamine, it helps to reduce the symptoms of allergic rhinitis.
Frequency not defined
Transient nasal stinging
Unpleasant taste
Epistaxis
Headache
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
When exposed to allergens, mast cells release inflammatory mediators, such as histamine, leading to allergic symptoms.
Cromolyn sodium intranasal stabilizes mast cell membranes, preventing the release of these inflammatory mediators.
Pharmacodynamics
Cromolyn sodium intranasal inhibits the degranulation process of mast cells.
By preventing this degranulation, cromolyn sodium reduces the release of inflammatory mediators.
Pharmacokinetics
Absorption
Cromolyn sodium is absorbed through the nasal mucosa.
Distribution
Cromolyn sodium is distributed locally within the nasal tissues.
Metabolism
Cromolyn sodium undergoes minimal hepatic metabolism.
Elimination and excretion
Cromolyn sodium is excreted by the kidneys.
Administration
Cromolyn sodium is administered intranasally, in form of nasal spray.
Patient information leaflet
Generic Name: cromolyn sodium, intranasal
Why do we use cromolyn sodium, intranasal?
Cromolyn sodium intranasal is commonly used to prevent and manage symptoms associated with seasonal allergies.
Cromolyn sodium intranasal can help reduce nasal congestion associated with allergic rhinitis.