culmerciclib

Action and Spectrum

Actions and spectrum:  

The drug inhibits the activity of CDK4 and CDK6.  

Culmerciclib stops the cell cycle in the G1 phase and prevent cancer cells from replicating further.  

Drug Interaction

Adverse Reaction

Adverse Reactions: 

Frequency not defined

vomiting  

Appetite  

Hair loss  

Fatigue  

Nausea   

Neuropathy 

Black Box Warning

Contraindication / Caution

Contraindication/Caution:  

The drug is contraindicated in following situations:  

Hypersensitivity 

Severe bone marrow suppression 

Uncontrolled heart rhythm problems 

Pregnancy / Lactation

Pregnancy Warnings:  

Pregnancy category: N/A  

Lactation:  

Excretion of the drug in human breast milk is unknown  

Pregnancy Categories:    

Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or in the later trimester.    

<b>Category B: No evidence of risk to fetus found in animal reproduction studies and there are not enough studies on pregnant women.    

Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women.    

Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits.    

Category X: Drugs listed in this category clearly outweigh risks over benefits. These category drugs should be prohibited for pregnant women.    

Category N: There is no data available for the drug under this category.      

Pharmacology

Pharmacology:  

Culmerciclib belongs to a class called cyclin-dependent kinase (CDK) inhibitors. They can reduce tumors and uncontrolled growth of cancer cells.  

Pharmacodynamics:  

Culmerciclib stops cancer cell proliferation. This can lead to tumor growth inhibition as existing cancer cells are prevented from replicating.   

Pharmacokinetics:  

Limited information available on ADME. 

Adminstartion

Administration:  

The administrations of culmerciclib are not fully known as it is under investigation.

Patient Information Leaflet

Patient information leaflet  

Generic Name: culmerciclib  

Why do we use culmerciclib?  

Culmerciclib is an investigational drug which is indicated for its action against cancer.