danaparoid

Action and Spectrum

Actions and Spectrum: 

Danaparoid is typically used to prevent and treat blood clots, specifically those that occur in the veins of the legs (deep vein thrombosis) and those that travel to the lungs (pulmonary embolism).  

Drug Interaction

Adverse Reaction

Black Box Warning

Black Box Warning: 

It is essential to follow the dosage and administration instructions for danaparoid carefully, as an overdose can cause serious side effects. 

Contraindication / Caution

Contraindication/Caution: 

danaparoid should not be used in people hypersensitive to the drug itself. 

Pregnancy / Lactation

Pregnancy consideration:  

Insufficient data is available regarding the effect of the drug on the fetus during pregnancy. Administer the drug in this case only if extremely required. 

Breastfeeding warnings:  

Breastfeeding should not be performed during drug administration. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.        
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.        
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.       
• Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.        
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.        
• Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology 

It works by inhibiting factors Xa and IIa. It prevents the formation of fibrin in the coagulation pathway through the inhibition of thrombogenesis. 

Pharmacokinetics: 

danaparoid has a half-life of 3-4 hours. It is not suitable for people with hepatic or renal disturbance.  

Pharmacodynamics: 

danaparoid works by activating the enzyme inhibitor, which helps to prevent the formation of blood clots. It also increases the activity of anti-clotting proteins called antithrombin III and heparin cofactor II, which help to inhibit the action of clotting factors. Additionally, danaparoid has anti-inflammatory effects and may help to reduce inflammation in the blood vessels. 

Absorption 

danaparoid is administered by injection and is rapidly absorbed into the bloodstream. 

Distribution 

After it is absorbed, danaparoid is distributed throughout the body and can be found in high concentrations in the liver, spleen, and bone marrow. 

Metabolism 

The metabolism of danaparoid occurs primarily in the liver. There it is metabolized into several active and inactive metabolites.  

Elimination and excretion 

These metabolites are then eliminated from the body through the kidneys and feces. 

Adminstartion

Administration: 

The danaparoid is administered through the intravenous route. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: danaparoid 

Pronounced: dan-a-par-oid 

Why do we use danaparoid? 

danaparoid treats deep vein thrombosis, catheter patency, and heparin-induced thrombocytopenia.