What Happens When You’re Just Mind Blanking
December 27, 2025
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Brand Name :
N/A
Synonyms :
dapivirine intravaginal
Class :
HIV, Non-nucleoside reverse transcriptase inhibitor (NNRTIs)
Brand Name :
N/A
Synonyms :
dapivirine intravaginal
Class :
HIV, Non-nucleoside reverse transcriptase inhibitor (NNRTIs)
Monthly once vaginal ring but FDA approval pending for prevention of human immune virus infection
Not suggested yet
Refer to adult dosing
Actions and Spectrum
The reverse transcriptase enzyme, which is necessary for HIV replication, is inhibited by dapivirine intravaginal. It prevents the virus from turning its RNA into DNA by inhibiting this enzyme.
The most prevalent type of the virus that causes the worldwide HIV epidemic, HIV-1, is specifically susceptible to the action of the drug dapivirine.
None
Black Box Warning:
None
Contraindication/Caution:
None
Pregnancy warnings:
Pregnancy category: N/A
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
dapivirine intravaginal belongs to the class of non-nucleoside reverse transcriptase inhibitors (NNRTIs). It inhibits the reverse transcriptase enzyme of the human immunodeficiency virus type 1 (HIV-1).
Pharmacodynamics
Limited information available
Pharmacokinetics
Limited information available on ADME
Administration
dapivirine intravaginal is administered using a specifically designed intravaginal ring (IVR).
Patient information leaflet
Generic Name: dapivirine intravaginal (FDA Approval Pending)
Why do we use dapivirine intravaginal?
dapivirine intravaginal is used as a form of pre-exposure prophylaxis to reduce the risk of HIV-1 infection in women.
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