- March 23, 2022
- Newsletter
- 617-430-5616
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Brand Name :
Chloroquine phosphate
Synonyms :
dapsone
Class :
Antileprosy; Sulfonamides/Sulfone
Brand Name :
Chloroquine phosphate
Synonyms :
dapsone
Class :
Antileprosy; Sulfonamides/Sulfone
Dosage forms & Strengths:
Adult:
Tablet:
25 mg
100 mg
50 mg orally each day
Titrate the dose to 300 mg each day or higher to get the desired effect
Later, reduce the dose to the minimum least effective in the range of 50-300 mg/day
100 mg orally each day, combined with other antileprosy agents
1-2 mg/kg orally each day
Do not exceed 100 mg/day when combined with antileprosy agents
Administer the dose for a minimum of 3 years by combining it with a multidrug regimen like rifampin
may enhance the risk of adverse effect of dapsone
may enhance the risk of adverse effect of dapsone
may enhance the risk of adverse effect of dapsone
may enhance the risk of adverse effect of dapsone
may enhance the risk of adverse effect of dapsone
may increase the toxic effect of Methemoglobinemia Associated Agen
methemoglobinemia associated agents may enhance the adverse/toxic effect of local anesthetics
methemoglobinemia associated agents may enhance the adverse/toxic effect of local anesthetics
methemoglobinemia associated agents may enhance the adverse/toxic effect of local anesthetics
methemoglobinemia associated agents may enhance the adverse/toxic effect of local anesthetics
methemoglobinemia associated agents may enhance the adverse/toxic effect of local anesthetics
may enhance the risk of adverse/toxic effect of dapsone
may enhance the risk of adverse/toxic effect of dapsone
may have an increasingly adverse effect when combined with local anesthetics
may have an increasingly adverse effect when combined with local anesthetics
may have an increasingly adverse effect when combined with local anesthetics
may have an increasingly adverse effect when combined with local anesthetics
may have an increasingly adverse effect when combined with local anesthetics
may have an increasingly adverse effect when combined with methemoglobinemia agents
may have an increasingly adverse effect when combined with methemoglobinemia agents
may have an increasingly adverse effect when combined with methemoglobinemia agents
may have an increasingly adverse effect when combined with methemoglobinemia agents
may have an increasingly adverse effect when combined with methemoglobinemia agents
when both drugs are combined, there may be a decreased metabolism of etoposide
when both drugs are combined, there may be a reduced metabolism of paclitaxel
when both drugs are combined, there may be an increased risk of nerve damage
the effect of dapsone is decreased by lorlatinib, by altering intestinal or hepatic CYP3A4 enzyme metabolism
trimethoprim increases the concentration of dapsone in serum
pramoxine /hydrocortisone topical
may increase the adverse effect
may increase the toxic effect
may increase the toxic effect
may increase the toxic effects of local anaesthetics
adapalene and benzoyl peroxide
may increase the toxic effect of benzoyl peroxide
may increase the toxic effect of local anesthetics
may increase the toxic effect of local anesthetics
may have an increasingly adverse effect when combined with local anesthetics
may have an increasingly adverse effect when combined with local anesthetics
may have an increasingly adverse effect when combined with local anesthetics
may have an increasingly adverse effect when combined with local anesthetics
may have an increasingly adverse effect when combined with local anesthetics
may increases the adverse effect of Local Anesthetics
may increase the adverse effect of Local Anesthetics
may have an increasingly adverse effect when combined with methemoglobinemia agents
may have an increasingly adverse effect when combined with methemoglobinemia agents
may have an increasingly adverse effect when combined with prilocaine
may increase the toxic effect of Methemoglobinemia Associated Agents
sodium thiosulfate & sodium nitrite
may have an increasingly adverse effect when combined with sodium nitrite
may increase the toxic effect of Methemoglobinemia Associated Agents
may increase the toxic effect of Local Anesthetics
1-10%:
Hemolysis
Methemoglobinemia
<1%:
Insomnia
Headache
Exfoliative dermatitis
Photosensitivity
Nausea
Vomiting
Anemia
Leukopenia
Agranulocytosis
Hepatitis
Cholestatic jaundice
Peripheral neuropathy
Blurred vision
Tinnitus
SLE
Dapsone is contraindicated in people hypersensitive to it.
Pregnancy consideration:
Category C
Breastfeeding warnings:
Dapsone is not compatible during nursing/breastfeeding
Pregnancy category:
Patient information leaflet
Generic Name: dapsone
Pronounced: dap-sone
Why do we use dapsone?
Dapsone treats Dermatitis Herpetiformis, Lepromatous Disease, leprosy, and Pneumocystis (Carinii) Jiroveci.