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Brand Name :
N/A
Synonyms :
darizmetinib
Class :
Mitogen-activated protein 2 kinase inhibitor
Brand Name :
N/A
Synonyms :
darizmetinib
Class :
Mitogen-activated protein 2 kinase inhibitor
Dosage Forms & StrengthsÂ
It is under investigation for NASH and hepatocellular carcinoma. As it is still under clinical trials, its safety and effectiveness are not determinedÂ
It is studied for its potential to treat liver diseases such as non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC)
It is still in the early stages of clinical trials and its efficacy and safety are yet to be established
Not determinedÂ
Refer to adult dosingÂ
Actions and SpectrumÂ
Darizmetinib, a MAP2K inhibitor, is employed to treat cancer. MAP4K is an essential regulator of liver regeneration.Â
Frequency not definedÂ
NoneÂ
Black Box WarningÂ
There is no black box warningÂ
Contraindication/Caution:Â
There are no specific contraindicationsÂ
Pregnancy/LactationÂ
Pregnancy consideration:Â
Pregnancy category: Not assignedÂ
Lactation: Excretion into human milk is unknownÂ
Pregnancy Categories:Â
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.Â
Category B: There were a lack of studies on pregnant women and no evidence of risk to the fetus in animal experimentsÂ
Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.Â
Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.Â
Category N: There is no data available for the drug under this category.Â
PharmacologyÂ
Not knownÂ
PharmacodynamicsÂ
There is no sufficient data available.Â
PharmacokineticsÂ
Limited information available on ADME.Â
AdministrationÂ
Darizmetinib is under clinical trials hence the administration is not known.Â
Patient information leafletÂ
Generic Name: darizmetinibÂ
Why do we use darizmetinib?Â
Darizmetinib is being investigated for the treatment of liver diseases like NASH and HCC, showing potential to boost liver regeneration and decrease hepatocyte death.Â
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