- March 23, 2022
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Brand Name :
Prezista
Synonyms :
darunavir
Class :
Antiviral agents and Anti-HIV (antiretroviral)
Dosage Forms & Strengths
Solution, Oral:
100 mg/ml
Tablet, Oral:
75 mg
150 mg
600 mg
800 mg
It may diminish the effect when combined with phenobarbital by affecting the intestinal/hepatic enzyme CYP3A4 metabolism
It may enhance the effect when combined with irinotecan liposomal by affecting CYP3A4 metabolism
darunavir: they may enhance serum concentrations of rifabutin
when both drugs are combined, there may be an increased risk of adverse effects
darunavir can impact the hepatic/intestinal enzyme CYP3A4 metabolism, leading to an elevation in the level or potency of intranasal midazolam
when both drugs are combined, there may be an increased level or effect of romidepsin by affecting hepatic or intestinal enzyme cyp3a4 metabolism
CYP3A strong enhancers of the small intestine may reduce the bioavailability of darunavir
darunavir increases the effect of fedratinib by altering the intestinal/hepatic CYP3A4 enzyme metabolism
it increases the effect or level of ruxolitinib by altering the intestinal or hepatic CYP3A4 enzyme metabolism
may increase the level of effectiveness through P-glycoprotein MDR1 efflux transporter
may enhance the serum concentration of elbasvir/grazoprevir
It may enhance the effect when combined with miconazole vaginal by affecting CYP3A4 metabolism
nafcillin will decrease the effect of action of darunavir by affecting enzyme CYP3A4 metabolism.
cyclophosphamide effect of action increased by affecting enzyme CYP3A4 metabolism.
when both drugs are combined, there may be an increased level of serum concentration of etoposide
has a synergistic effect over brentuximab vedotin, by showing altered intestinal/hepatic CYP3A4 enzyme metabolism.
May increase plasma concentration and therapeutic effects of other antiretroviral drugs
May increase plasma concentration and therapeutic effects of other antiretroviral drugs
may increase the level by affecting hepatic enzyme CYP3A4 metabolism
may enhance the serum concentration
insulin degludec/insulin aspart
may diminish the effects of each other by pharmacodynamic antagonism
may increase the level by affecting the hepatic enzyme CYP3A4 metabolism
darunavir, when taken with ixazomib, alters the intestinal/hepatic CYP3A4 enzyme metabolism
Frequency defined:
>10%
Skin rash
Vomiting
Bronchitis
Cough
Upper respiratory tract infection
Fever
1% to 10%:
Acute myocardial infection
Cardiac failure
Coronary artery disease
Coronary occlusion
Endocarditis
Hypertension
Ischemic heart disease
Portal vein thrombosis
Septic shock
Unstable angina pectoris
Acne vulgaris
Alopecia
Folliculitis
Nail disease
Pruritis
Sweat gland disease
Lipodystrophy
Frequency not defined:
Hepatitis
Hepatotoxicity
Immune reconstitution syndrome
Post-marketing:
Stevens-Johnson syndrome
Toxic epidermal necrolysis
Drug rash with eosinophilia
Pregnancy consideration: Darunavir may transfer in moderate to high amounts across the human placenta.
Lactation: excretion of darunavir in breast milk is not known.
Pregnancy category:
Patient information leaflet
Generic Name: Darunavir
Pronunciation: darunavir
Why do we use Darunavir?
It is used to treat viral infections such as HIV infection.
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