Anthropometric Measurements as Predictors of Low Birth Weight Among Tanzanian Neonates: A Hospital-Based Study
November 7, 2025
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Brand Name :
defitelio
Synonyms :
defibrotide
Class :
thrombolytics
Brand Name :
defitelio
Synonyms :
defibrotide
Class :
thrombolytics
Dosage Forms & StrengthsÂ
IV solutionÂ
200mg/2.5ml vialÂ
Hepatic Veno-occlusive DiseaseÂ
6.25
mg/kg
Solution
Intravenous (IV)
every 6 hours over 2 hours
Administer for 21 days
Dosage Forms & StrengthsÂ
IV solutionÂ
200mg/2.5ml vialÂ
Hepatic Veno-occlusive DiseaseÂ
6.25
mg/kg
Solution
Intravenous (IV)
every 6 hours over 2 hours
Administer for 21 days
When defibrotide is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
may decrease the effect of each other through pharmacodynamic antagonism
the anticoagulant activity of defibrotide may be reduced
Frequency defined:Â Â
>10%Â
EpistaxisÂ
VomitingÂ
HypotensionÂ
DiarrheaÂ
NauseaÂ
1-10%Â
Gastrointestinal hemorrhageÂ
PneumoniaÂ
InfectionÂ
HyperuricemiaÂ
Hypersensitivity reactionsÂ
Pulmonary alveolar hemorrhageÂ
SepsisÂ
Lung infiltrationÂ
Pulmonary hemorrhageÂ
Hemorrhage intracranialÂ
Cerebral hemorrhageÂ
Pregnancy consideration: Insufficient data availableÂ
Lactation: Excretion of the drug in human breast milk is unknownÂ
Pregnancy category:Â
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.  Â
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.Â
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   Â
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.   Â
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.   Â
Category N: There is no data available for the drug under this categoryÂ
Patient information leafletÂ
Generic Name: defibrotideÂ
Pronounced: [ de-FYE-broe-tide]Â
Why do we use defibrotide?Â
It is used to treat severe Hepatic veno-occlusive diseaseÂ
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