How Far Is Too Far? The Ethics of Mini Brain Research
December 11, 2025
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Brand Name :
defitelio
Synonyms :
defibrotide
Class :
thrombolytics
Brand Name :
defitelio
Synonyms :
defibrotide
Class :
thrombolytics
Dosage Forms & Strengths
IV solution
200mg/2.5ml vial
Hepatic Veno-occlusive Disease
6.25
mg/kg
Solution
Intravenous (IV)
every 6 hours over 2 hours
Administer for 21 days
Dosage Forms & Strengths
IV solution
200mg/2.5ml vial
Hepatic Veno-occlusive Disease
6.25
mg/kg
Solution
Intravenous (IV)
every 6 hours over 2 hours
Administer for 21 days
When defibrotide is used together with andrographolide, this leads to enhanced risk or seriousness of bleeding
may decrease the effect of each other through pharmacodynamic antagonism
the anticoagulant activity of defibrotide may be reduced
Frequency defined:
>10%
Epistaxis
Vomiting
Hypotension
Diarrhea
Nausea
1-10%
Gastrointestinal hemorrhage
Pneumonia
Infection
Hyperuricemia
Hypersensitivity reactions
Pulmonary alveolar hemorrhage
Sepsis
Lung infiltration
Pulmonary hemorrhage
Hemorrhage intracranial
Cerebral hemorrhage
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Patient information leaflet
Generic Name: defibrotide
Pronounced: [ de-FYE-broe-tide]
Why do we use defibrotide?
It is used to treat severe Hepatic veno-occlusive disease
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