demeclocycline

DRUG INTERACTION

Contraindicated  

Serious Use Alternative  

Monitor Closely  

Minor  

Frequency not defined:  

Esophageal ulcer 

Increased liver enzymes 

Visual disturbance 

Dysphagia 

Glossitis 

Nausea 

Vomiting 

Diarrhea 

Hepatotoxicity 

Reversible and more frequent photosensitivity reaction 

Dose-related diabetes insipidus  

Discoloration of teeth 

Superinfection, monilial 

 

Pregnancy considerations: demeclocycline can be assigned under pregnancy category D. Avoid during pregnancy. 

Lactation: Demeclocycline can be excreted in breast milk and may cause tooth discoloration in infants. Avoid use during breastfeeding.  

Pregnancy category: 

• Category A: Satisfactory and well-controlled studies show no evidence of risk to the fetus in the first trimester or the later trimester. 
• Category B: There is no evidence of risk to the fetus found in animal reproduction studies and there are not enough studies on pregnant women. 
• Category C: Adverse effects on the fetus found with evidence in animal reproduction studies and no adequate evidence for an effect in humans, care must be taken for potential risks in pregnant women. 
• Category D: There is adequate data available with sufficient evidence of human fetal risk from various platforms, but despite potential risks may be used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh risks over benefits. These category drugs should be prohibited for pregnant women. 
• Category N: There is no data available for the drug under this category. 

Patient information leaflet 

Generic Name: Demeclocycline 

Pronounced: de-me-klo-si-klin 

 

Why do we use demeclocycline? 

Demeclocycline is a tetracycline derivative antibiotic drug. It is used to treat bacterial infections where penicillins are contraindicated. It kills bacteria by inhibiting bacterial protein synthesis and causes alteration in the cytoplasmic membrane.