demoxytocin is a medication that mimics the action of oxytocin, a hormone produced naturally in the body. It primarily acts on the uterus and mammary glands.
Uterine Contraction: demoxytocin stimulates uterine contractions, making it useful in the induction of labor and management of postpartum hemorrhage.
Milk Ejection: It promotes milk ejection by contracting the smooth muscles around the milk ducts, facilitating breastfeeding.
The spectrum of demoxytocin’s action is limited to these uterine and mammary gland-related functions. It is not used for other purposes due to its specific effects on these tissues.
When a normal contraction rhythm develops, the rate is reduced to 25 units every 30 minutes from 50 units every 30 minutes. Maximum dose: 500 units
Safety and efficacy were not established
Refer to the adult dosing regimen
Frequency not defined
Postpartum bleeding
water retention
neonatal jaundice
transient hypotension
anaphylactic reactions
maternal deaths
fatal afibrinogenemia
subarachnoid hemorrhage
Black Box Warning:
There is no specific black box warning associated with demoxytocin.
Contraindication/Caution:
Contraindication:
Hypersensitivity: Individuals who are known to be hypersensitive or allergic to demoxytocin or any of its components should not use this medication.
Fetal Distress: It should not be administered if the fetus is in distress, as it can increase uterine contractions and potentially worsen the fetal condition.
Unfavourable Cervix: If the cervix is not yet favourable (not dilated or effaced sufficiently), using demoxytocin to induce labor may not be appropriate.
Abnormal Fetal Presentation: It is contraindicated when there is an abnormal fetal presentation, such as a breech or transverse position of the baby.
Uterine Rupture: Women with a history of uterine rupture should avoid using demoxytocin, as it can increase the risk of uterine rupture.
Severe Pelvic Deformities: In cases of severe pelvic deformities that might obstruct the passage of the baby, the use of demoxytocin can be contraindicated.
Caution:
Fetal Monitoring: Continuous fetal monitoring is essential during demoxytocin administration. This ensures that the baby’s heart rate and well-being are closely monitored, and any signs of fetal distress can be detected promptly.
Uterine Hyperstimulation: demoxytocin can lead to uterine hyperstimulation, where contractions become too frequent or too strong. This can compromise fetal oxygen supply. Healthcare providers should adjust the dosage if uterine hyperstimulation occurs.
Water Intoxication: Prolonged or excessive administration of demoxytocin can lead to water intoxication in the mother due to excessive fluid retention. This can result in electrolyte imbalances and seizures. Careful monitoring of fluid balance is necessary.
Maternal Blood Pressure: demoxytocin can cause changes in maternal blood pressure, including hypotension (low blood pressure) or hypertension (high blood pressure). Blood pressure should be monitored regularly.
Previous Uterine Surgery: Women with a history of uterine surgery, such as myomectomy, should be monitored closely during demoxytocin administration, as there may be an increased risk of uterine rupture.
Pelvic Deformities: In cases of severe pelvic deformities, demoxytocin should be used with caution as it may affect the progress of labor.
Comorbidities:
Hypertension: Individuals with pre-existing hypertension may require careful monitoring of blood pressure during demoxytocin administration, as this medication can affect blood pressure.
Diabetes: Patients should be closely monitored during labor, as demoxytocin may influence blood glucose levels.
Cardiovascular Disease: Individuals with heart conditions may be at increased risk during labor and should be carefully evaluated and monitored.
Renal Disease: Kidney function may be affected using demoxytocin, particularly due to changes in fluid balance. Patients with renal disease may need special attention.
Asthma: Asthmatic patients should be monitored, as some individuals may experience bronchospasm or exacerbation of asthma symptoms with demoxytocin use.
Pregnancy consideration: pregnancy category: not assigned
Lactation: excreted into breast milk: unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
demoxytocin is a synthetic form of oxytocin, a hormone produced naturally in the human body by the hypothalamus and released by posterior pituitary gland. Oxytocin plays a crucial role in uterine contractions during labor and stimulates milk ejection during breastfeeding. demoxytocin mimics these effects when administered as a medication. It binds to oxytocin receptors on the uterine muscle cells, leading to increased contractility of the uterus. This uterine stimulation is used in obstetrics to induce or augment labor when necessary.
Pharmacodynamics:
Uterine Contraction: demoxytocin binds to oxytocin receptors on the uterine muscle cells, leading to increased uterine contractions. This effect is used in obstetrics to induce labor or strengthen contractions during labor.
Milk Ejection: demoxytocin stimulates oxytocin receptors in the mammary glands, causing the contraction of myoepithelial cells surrounding the alveoli and ducts. This contraction results in the ejection of milk from the mammary glands, facilitating breastfeeding.
Positive Feedback Loop: Oxytocin release, including that induced by demoxytocin administration, can create a positive feedback loop during labor. As contractions push the baby’s head against the cervix, this pressure stimulates the release of more oxytocin, which, in turn, enhances contractions, leading to cervical dilation and eventual delivery.
Social Bonding: Oxytocin, and by extension, demoxytocin, is often associated with social bonding and maternal-infant attachment. It may play a role in promoting emotional bonding between mothers and infants.
Blood Pressure Regulation: In some cases, demoxytocin administration can lead to transient decrease in the blood pressure due to vasodilation.
Pharmacokinetics:
Absorption
demoxytocin is usually administered via intravenous or intramuscular injection, which allows for rapid and direct absorption into the bloodstream. When given intranasally, it can be absorbed through the nasal mucosa.
Distribution
Once in the bloodstream, demoxytocin is distributed throughout the body, including to the uterus and mammary glands where it exerts its primary effects. It also crosses the blood-brain barrier, influencing social and emotional responses.
Metabolism
demoxytocin is rapidly metabolized by enzymes in the liver and other tissues. The exact metabolic pathways are not well understood, but it is thought to undergo enzymatic degradation.
Elimination and excretion
The metabolites of demoxytocin and any unmetabolized drug are primarily excreted through the kidneys in the urine. The drug is eliminated quickly from the body.
Administration:
Intravenous (IV) Infusion: A diluted solution of demoxytocin, and it is administered through an IV line.
Intramuscular (IM) Injection: In some cases, demoxytocin may be given as an intramuscular injection. This is less common than IV administration and may be used if IV access is not readily available.
Intranasal: In certain situations, such as for social or emotional effects rather than uterine stimulation, demoxytocin may be administered intranasally through a nasal spray. This method is used less frequently in clinical settings.
Patient information leaflet
Generic Name: demoxytocin
Pronounced: (deh-mock-si-TOE-sin)
Why do we use demoxytocin?
Induction of Labor: demoxytocin is used in pregnant women to induce labor who have passed their due dates or when there are medical reasons for initiating labor, such as preeclampsia or fetal distress.
Augmentation of Labor: In cases where labor is progressing slowly or inefficiently, demoxytocin may be administered to strengthen and speed up contractions.
Management of Postpartum Hemorrhage: demoxytocin can help prevent or manage excessive bleeding following childbirth by causing the uterus to contract and reduce bleeding.
Control of Uterine Atony: Uterine atony is when the uterus fails to contract adequately after childbirth. demoxytocin can be used to stimulate uterine contractions and reduce the risk of postpartum hemorrhage.
Treatment of Diabetes Insipidus: demoxytocin may be used to treat central diabetes insipidus, a condition characterized by excessive thirst and urine production due to insufficient vasopressin secretion.
When a normal contraction rhythm develops, the rate is reduced to 25 units every 30 minutes from 50 units every 30 minutes. Maximum dose: 500 units
Safety and efficacy were not established
Refer to the adult dosing regimen
DRUG INTERACTION
demoxytocin
&
demoxytocin +
No Drug Intearction Found. for demoxytocin and .
Actions and spectrum:
demoxytocin is a medication that mimics the action of oxytocin, a hormone produced naturally in the body. It primarily acts on the uterus and mammary glands.
Uterine Contraction: demoxytocin stimulates uterine contractions, making it useful in the induction of labor and management of postpartum hemorrhage.
Milk Ejection: It promotes milk ejection by contracting the smooth muscles around the milk ducts, facilitating breastfeeding.
The spectrum of demoxytocin’s action is limited to these uterine and mammary gland-related functions. It is not used for other purposes due to its specific effects on these tissues.
Frequency not defined
Postpartum bleeding
water retention
neonatal jaundice
transient hypotension
anaphylactic reactions
maternal deaths
fatal afibrinogenemia
subarachnoid hemorrhage
Black Box Warning:
There is no specific black box warning associated with demoxytocin.
Contraindication/Caution:
Contraindication:
Hypersensitivity: Individuals who are known to be hypersensitive or allergic to demoxytocin or any of its components should not use this medication.
Fetal Distress: It should not be administered if the fetus is in distress, as it can increase uterine contractions and potentially worsen the fetal condition.
Unfavourable Cervix: If the cervix is not yet favourable (not dilated or effaced sufficiently), using demoxytocin to induce labor may not be appropriate.
Abnormal Fetal Presentation: It is contraindicated when there is an abnormal fetal presentation, such as a breech or transverse position of the baby.
Uterine Rupture: Women with a history of uterine rupture should avoid using demoxytocin, as it can increase the risk of uterine rupture.
Severe Pelvic Deformities: In cases of severe pelvic deformities that might obstruct the passage of the baby, the use of demoxytocin can be contraindicated.
Caution:
Fetal Monitoring: Continuous fetal monitoring is essential during demoxytocin administration. This ensures that the baby’s heart rate and well-being are closely monitored, and any signs of fetal distress can be detected promptly.
Uterine Hyperstimulation: demoxytocin can lead to uterine hyperstimulation, where contractions become too frequent or too strong. This can compromise fetal oxygen supply. Healthcare providers should adjust the dosage if uterine hyperstimulation occurs.
Water Intoxication: Prolonged or excessive administration of demoxytocin can lead to water intoxication in the mother due to excessive fluid retention. This can result in electrolyte imbalances and seizures. Careful monitoring of fluid balance is necessary.
Maternal Blood Pressure: demoxytocin can cause changes in maternal blood pressure, including hypotension (low blood pressure) or hypertension (high blood pressure). Blood pressure should be monitored regularly.
Previous Uterine Surgery: Women with a history of uterine surgery, such as myomectomy, should be monitored closely during demoxytocin administration, as there may be an increased risk of uterine rupture.
Pelvic Deformities: In cases of severe pelvic deformities, demoxytocin should be used with caution as it may affect the progress of labor.
Comorbidities:
Hypertension: Individuals with pre-existing hypertension may require careful monitoring of blood pressure during demoxytocin administration, as this medication can affect blood pressure.
Diabetes: Patients should be closely monitored during labor, as demoxytocin may influence blood glucose levels.
Cardiovascular Disease: Individuals with heart conditions may be at increased risk during labor and should be carefully evaluated and monitored.
Renal Disease: Kidney function may be affected using demoxytocin, particularly due to changes in fluid balance. Patients with renal disease may need special attention.
Asthma: Asthmatic patients should be monitored, as some individuals may experience bronchospasm or exacerbation of asthma symptoms with demoxytocin use.
Pregnancy consideration: pregnancy category: not assigned
Lactation: excreted into breast milk: unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
demoxytocin is a synthetic form of oxytocin, a hormone produced naturally in the human body by the hypothalamus and released by posterior pituitary gland. Oxytocin plays a crucial role in uterine contractions during labor and stimulates milk ejection during breastfeeding. demoxytocin mimics these effects when administered as a medication. It binds to oxytocin receptors on the uterine muscle cells, leading to increased contractility of the uterus. This uterine stimulation is used in obstetrics to induce or augment labor when necessary.
Pharmacodynamics:
Uterine Contraction: demoxytocin binds to oxytocin receptors on the uterine muscle cells, leading to increased uterine contractions. This effect is used in obstetrics to induce labor or strengthen contractions during labor.
Milk Ejection: demoxytocin stimulates oxytocin receptors in the mammary glands, causing the contraction of myoepithelial cells surrounding the alveoli and ducts. This contraction results in the ejection of milk from the mammary glands, facilitating breastfeeding.
Positive Feedback Loop: Oxytocin release, including that induced by demoxytocin administration, can create a positive feedback loop during labor. As contractions push the baby’s head against the cervix, this pressure stimulates the release of more oxytocin, which, in turn, enhances contractions, leading to cervical dilation and eventual delivery.
Social Bonding: Oxytocin, and by extension, demoxytocin, is often associated with social bonding and maternal-infant attachment. It may play a role in promoting emotional bonding between mothers and infants.
Blood Pressure Regulation: In some cases, demoxytocin administration can lead to transient decrease in the blood pressure due to vasodilation.
Pharmacokinetics:
Absorption
demoxytocin is usually administered via intravenous or intramuscular injection, which allows for rapid and direct absorption into the bloodstream. When given intranasally, it can be absorbed through the nasal mucosa.
Distribution
Once in the bloodstream, demoxytocin is distributed throughout the body, including to the uterus and mammary glands where it exerts its primary effects. It also crosses the blood-brain barrier, influencing social and emotional responses.
Metabolism
demoxytocin is rapidly metabolized by enzymes in the liver and other tissues. The exact metabolic pathways are not well understood, but it is thought to undergo enzymatic degradation.
Elimination and excretion
The metabolites of demoxytocin and any unmetabolized drug are primarily excreted through the kidneys in the urine. The drug is eliminated quickly from the body.
Administration:
Intravenous (IV) Infusion: A diluted solution of demoxytocin, and it is administered through an IV line.
Intramuscular (IM) Injection: In some cases, demoxytocin may be given as an intramuscular injection. This is less common than IV administration and may be used if IV access is not readily available.
Intranasal: In certain situations, such as for social or emotional effects rather than uterine stimulation, demoxytocin may be administered intranasally through a nasal spray. This method is used less frequently in clinical settings.
Patient information leaflet
Generic Name: demoxytocin
Pronounced: (deh-mock-si-TOE-sin)
Why do we use demoxytocin?
Induction of Labor: demoxytocin is used in pregnant women to induce labor who have passed their due dates or when there are medical reasons for initiating labor, such as preeclampsia or fetal distress.
Augmentation of Labor: In cases where labor is progressing slowly or inefficiently, demoxytocin may be administered to strengthen and speed up contractions.
Management of Postpartum Hemorrhage: demoxytocin can help prevent or manage excessive bleeding following childbirth by causing the uterus to contract and reduce bleeding.
Control of Uterine Atony: Uterine atony is when the uterus fails to contract adequately after childbirth. demoxytocin can be used to stimulate uterine contractions and reduce the risk of postpartum hemorrhage.
Treatment of Diabetes Insipidus: demoxytocin may be used to treat central diabetes insipidus, a condition characterized by excessive thirst and urine production due to insufficient vasopressin secretion.
demoxytocin is a medication that mimics the action of oxytocin, a hormone produced naturally in the body. It primarily acts on the uterus and mammary glands.
Uterine Contraction: demoxytocin stimulates uterine contractions, making it useful in the induction of labor and management of postpartum hemorrhage.
Milk Ejection: It promotes milk ejection by contracting the smooth muscles around the milk ducts, facilitating breastfeeding.
The spectrum of demoxytocin’s action is limited to these uterine and mammary gland-related functions. It is not used for other purposes due to its specific effects on these tissues.
Dosing & Uses
Drug Interaction
Adverse Reaction
Frequency not defined
Postpartum bleeding
water retention
neonatal jaundice
transient hypotension
anaphylactic reactions
maternal deaths
fatal afibrinogenemia
subarachnoid hemorrhage
Black Box Warning
Black Box Warning:
There is no specific black box warning associated with demoxytocin.
Contraindication / Caution
Contraindication/Caution:
Contraindication:
Hypersensitivity: Individuals who are known to be hypersensitive or allergic to demoxytocin or any of its components should not use this medication.
Fetal Distress: It should not be administered if the fetus is in distress, as it can increase uterine contractions and potentially worsen the fetal condition.
Unfavourable Cervix: If the cervix is not yet favourable (not dilated or effaced sufficiently), using demoxytocin to induce labor may not be appropriate.
Abnormal Fetal Presentation: It is contraindicated when there is an abnormal fetal presentation, such as a breech or transverse position of the baby.
Uterine Rupture: Women with a history of uterine rupture should avoid using demoxytocin, as it can increase the risk of uterine rupture.
Severe Pelvic Deformities: In cases of severe pelvic deformities that might obstruct the passage of the baby, the use of demoxytocin can be contraindicated.
Caution:
Fetal Monitoring: Continuous fetal monitoring is essential during demoxytocin administration. This ensures that the baby’s heart rate and well-being are closely monitored, and any signs of fetal distress can be detected promptly.
Uterine Hyperstimulation: demoxytocin can lead to uterine hyperstimulation, where contractions become too frequent or too strong. This can compromise fetal oxygen supply. Healthcare providers should adjust the dosage if uterine hyperstimulation occurs.
Water Intoxication: Prolonged or excessive administration of demoxytocin can lead to water intoxication in the mother due to excessive fluid retention. This can result in electrolyte imbalances and seizures. Careful monitoring of fluid balance is necessary.
Maternal Blood Pressure: demoxytocin can cause changes in maternal blood pressure, including hypotension (low blood pressure) or hypertension (high blood pressure). Blood pressure should be monitored regularly.
Previous Uterine Surgery: Women with a history of uterine surgery, such as myomectomy, should be monitored closely during demoxytocin administration, as there may be an increased risk of uterine rupture.
Pelvic Deformities: In cases of severe pelvic deformities, demoxytocin should be used with caution as it may affect the progress of labor.
Comorbidities:
Hypertension: Individuals with pre-existing hypertension may require careful monitoring of blood pressure during demoxytocin administration, as this medication can affect blood pressure.
Diabetes: Patients should be closely monitored during labor, as demoxytocin may influence blood glucose levels.
Cardiovascular Disease: Individuals with heart conditions may be at increased risk during labor and should be carefully evaluated and monitored.
Renal Disease: Kidney function may be affected using demoxytocin, particularly due to changes in fluid balance. Patients with renal disease may need special attention.
Asthma: Asthmatic patients should be monitored, as some individuals may experience bronchospasm or exacerbation of asthma symptoms with demoxytocin use.
Pregnancy / Lactation
Pregnancy consideration: pregnancy category: not assigned
Lactation: excreted into breast milk: unknown
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
<b>Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
Pharmacology:
demoxytocin is a synthetic form of oxytocin, a hormone produced naturally in the human body by the hypothalamus and released by posterior pituitary gland. Oxytocin plays a crucial role in uterine contractions during labor and stimulates milk ejection during breastfeeding. demoxytocin mimics these effects when administered as a medication. It binds to oxytocin receptors on the uterine muscle cells, leading to increased contractility of the uterus. This uterine stimulation is used in obstetrics to induce or augment labor when necessary.
Pharmacodynamics:
Uterine Contraction: demoxytocin binds to oxytocin receptors on the uterine muscle cells, leading to increased uterine contractions. This effect is used in obstetrics to induce labor or strengthen contractions during labor.
Milk Ejection: demoxytocin stimulates oxytocin receptors in the mammary glands, causing the contraction of myoepithelial cells surrounding the alveoli and ducts. This contraction results in the ejection of milk from the mammary glands, facilitating breastfeeding.
Positive Feedback Loop: Oxytocin release, including that induced by demoxytocin administration, can create a positive feedback loop during labor. As contractions push the baby’s head against the cervix, this pressure stimulates the release of more oxytocin, which, in turn, enhances contractions, leading to cervical dilation and eventual delivery.
Social Bonding: Oxytocin, and by extension, demoxytocin, is often associated with social bonding and maternal-infant attachment. It may play a role in promoting emotional bonding between mothers and infants.
Blood Pressure Regulation: In some cases, demoxytocin administration can lead to transient decrease in the blood pressure due to vasodilation.
Pharmacokinetics:
Absorption
demoxytocin is usually administered via intravenous or intramuscular injection, which allows for rapid and direct absorption into the bloodstream. When given intranasally, it can be absorbed through the nasal mucosa.
Distribution
Once in the bloodstream, demoxytocin is distributed throughout the body, including to the uterus and mammary glands where it exerts its primary effects. It also crosses the blood-brain barrier, influencing social and emotional responses.
Metabolism
demoxytocin is rapidly metabolized by enzymes in the liver and other tissues. The exact metabolic pathways are not well understood, but it is thought to undergo enzymatic degradation.
Elimination and excretion
The metabolites of demoxytocin and any unmetabolized drug are primarily excreted through the kidneys in the urine. The drug is eliminated quickly from the body.
Adminstartion
Administration:
Intravenous (IV) Infusion: A diluted solution of demoxytocin, and it is administered through an IV line.
Intramuscular (IM) Injection: In some cases, demoxytocin may be given as an intramuscular injection. This is less common than IV administration and may be used if IV access is not readily available.
Intranasal: In certain situations, such as for social or emotional effects rather than uterine stimulation, demoxytocin may be administered intranasally through a nasal spray. This method is used less frequently in clinical settings.
Patient Information Leaflet
Patient information leaflet
Generic Name: demoxytocin
Pronounced: (deh-mock-si-TOE-sin)
Why do we use demoxytocin?
Induction of Labor: demoxytocin is used in pregnant women to induce labor who have passed their due dates or when there are medical reasons for initiating labor, such as preeclampsia or fetal distress.
Augmentation of Labor: In cases where labor is progressing slowly or inefficiently, demoxytocin may be administered to strengthen and speed up contractions.
Management of Postpartum Hemorrhage: demoxytocin can help prevent or manage excessive bleeding following childbirth by causing the uterus to contract and reduce bleeding.
Control of Uterine Atony: Uterine atony is when the uterus fails to contract adequately after childbirth. demoxytocin can be used to stimulate uterine contractions and reduce the risk of postpartum hemorrhage.
Treatment of Diabetes Insipidus: demoxytocin may be used to treat central diabetes insipidus, a condition characterized by excessive thirst and urine production due to insufficient vasopressin secretion.
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