deslanoside

Action and Spectrum

Actions and Spectrum 

deslanoside exerts primarily through its influence on the sodium-potassium pump (Na+/K+ ATPase) in cardiac cells. This pump is responsible for maintaining the proper balance of sodium and potassium ions within the cells, which is crucial for the proper electrical activity and contraction of the heart muscle.  

Drug Interaction

Adverse Reaction

Frequency not defined  

Nausea  

Vomiting  

Abdominal pain 

Headache 

Facial pain  

Fatigue 

Anorexia  

Diarrhea  

Weakness  

Dizziness  

Drowsiness 

Disorientation  

Mental confusion 

Bad dreams 

Delirium  

Convulsions 

Blurred vision  

Gynecomastia 

Vasoconstriction 

Acute psychoses 

Hallucinations

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• deslanoside should not be used in individuals who have a known hypersensitivity or allergy to deslanoside or any of its components. 

Caution: 

• It should be used cautiously in patients with conditions that can lead to electrolyte imbalances. 
• Caution should be taken in patients with gastrointestinal disorders. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: C 

Lactation: Excretion into human milk is unknown  

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

Elevated intracellular calcium concentrations enhance the contractile strength and force of cardiac muscle fibers.  

This increased contractility is beneficial in conditions like congestive heart failure. 

Pharmacodynamics 

The inhibition of Na+/K+ ATPase results in an accumulation of intracellular sodium ions. This sodium accumulation indirectly affects the sodium-calcium exchanger, which normally exchanges one calcium ion for three sodium ions.  

Pharmacokinetics 

Absorption   

deslanoside is administered intravenously thus it allows for rapid absorption of the drug directly into the bloodstream. 

Distribution 

deslanoside is distributed throughout the body. 

Metabolism 

deslanoside undergoes limited metabolism in the liver. 

Elimination and excretion 

The primary route of excretion for deslanoside is through the kidneys.

Adminstartion

Administration 

deslanoside is administered through intravenously (IV). 

Patient Information Leaflet

Patient information leaflet 

Generic Name: deslanoside 

Why do we use deslanoside? 

deslanoside is used to treat congestive heart failure.   

deslanoside is also used to manage certain types of irregular heart rhythms, particularly atrial fibrillation, and atrial flutter.