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dexmedetomidine

Brand Name :

Precedex, Igalmi

Synonyms :

dexmedetomidine

Class :

Sedatives





No data available for drug.

Actions and spectrum: 

dexmedetomidine is a selective alpha-2 adrenergic agonist with a wide range of actions and a spectrum of effects. Its primary action is to stimulate alpha-2 receptors in brain and spinal cord, leading to sedation and analgesia. It also has sympatholytic properties, reducing sympathetic outflow and resulting in decreased blood pressure and heart rate.

dexmedetomidine has anxiolytic effects and can induce a state of calm and relaxation in patients. Additionally, it has been shown to have neuroprotective and anti-inflammatory properties. Its spectrum of effects includes sedation, analgesia, anxiolysis, sympatholysis, and neuroprotection. 

DRUG INTERACTION

dexmedetomidine

&

  • beta carotene/vitamin C/minerals
  • aloe vera gel/urea
  • aloe vera gel/glycerine
  • alpha-lipoic acid/benfotiamine/chromium/folic acid/mecobalamin / vit b6
  • alprazolam/propranolol
  • alprazolam /sertraline
  • ibuprofen/dextropropoxyphene
  • ambroxol/cetirizine/phenylephrine/ guaiphenesin/menthol
  • dextropropoxyphene/dexchlorpheniramine maleate/bromhexine
  • promegestone
  • batroxobin
  • bencyclane
  • benfluorex
  • acetylpheneturide
  • abarelix
  • abetimus
  • naftidrofuryl
  • nalorphine
  • oxiracetam
  • letosteine
  • lafutidine
  • leuprorelin
  • levodropropizine
  • glutaral
  • losartan/ramipril
  • gallopamil
  • lanatoside c
  • lauromacrogol
  • gestodene
  • aceclofenac/methyl salicylate/menthol/linseed oil/capsaicin
  • aceclofenac/paracetamol/tizanidine
  • alginic acid/magaldrate/simethicone
  • aceclofenac/paracetamol
  • aceclofenac/rabeprazole
  • alginic acid
  • pantoprazole and domperidone
  • urokinase
  • rimiterol
  • olanzapine/fluoxetine
  • normethadone/hydroxyephedrine
  • myrtol
  • moxonidine
  • propylhexedrine
  • sodium hypochlorite solution
  • sodium chloride/sodium citrate
  • Hepatitis B Vaccine (Recombinant [Adjuvanted])
  • Hepatitis B Vaccine (Recombinant)
  • aceclofenac and serratiopeptidase
  • levosulpiride
  • niaprazine
  • tromantadine
  • trimetazidine
  • vinburnine
  • mizoribine
  • molgramostim
  • mosapride
  • eugenol
  • tolperisone
  • etamsylate
  • etynodiol
  • mizolastine
  • metenolone
  • reproterol
  • rebamipide
  • mephenoxalone
  • metandienone
  • furosemide/spironolactone
  • hydroxycarbamide
  • tenonitrozole
  • fenoverine
  • fenquizone
  • tiapride
  • tibolone
  • furazolidone
  • furosemide & amiloride
  • fosfestrol
  • fluclorolone
  • flubendazole
  • tertatolol
  • tetracosactide
  • tetryzoline
  • tolciclate
  • trapidil
  • troxipide
  • temoporfin
  • telbivudine
  • teprenone
  • hexamidine
  • mebhydrolin
  • mepartricin
  • fencamfamin
  • medazepam
  • theodrenaline
  • thiamazole
  • thiocolchicoside
  • psilocybin
  • veralipride
  • pyritinol
  • opipramol
  • oprelvekin
  • betamethasone + gentamicin
  • betamethasone + neomycin
  • betamethasone + salicylic acid
  • oxedrine
  • bopindolol
  • orgotein (investigational)
  • oxaceprol
  • ormeloxifene
  • bevantolol
  • bifemelane
  • clebopride
  • demoxytocin
  • cicletanine
  • cefsulodin
  • chlortalidon
  • sisomicin
  • somatrem
  • carbazochrome
  • caroverine
  • cathine
  • ipriflavone
  • isepamicin
  • silymarin
  • simethicone
  • sermorelin
  • diloxanide
  • dimethindene
  • diosmin/hesperidin
  • calamine
  • canrenone
  • captodiame
  • imidapril
  • cefetamet
  • cefodizime
  • cefoperazone + sulbactam
  • ivermectin + albendazole
  • serrapeptase
  • bromisoval
  • beraprost
  • pridinol
  • proglumide
  • bamipine
  • barnidipine
  • bamifylline
  • benzbromarone
  • betamethasone/fusidic acid
  • para-chlorophenol
  • pantethine
  • nomifensine
  • pemoline
  • parnaparin
  • pentolinium
  • nialamide
  • novobiocin
  • nicergoline
  • octocrylene
  • octisalate
  • oftasceine
  • oxolamine
  • oxyphencyclimine
  • penfluridol
  • pentoxyverine
  • phenoxymethylpenicillin
  • picloxydine
  • pilsicainide hydrochloride
  • piperazine
  • pirarubicin
  • policresulen
  • prifinium bromide
  • prethcamide
  • pristinamycin
  • pirenzepine
  • piribedil
  • pimethixene
  • pargyline
  • phosphatidyl choline
  • phthalylsulfathiazole
  • phytomenadione
  • pranlukast
  • pinazepam
  • oxyphenonium
  • noxytiolin
  • periciazine
  • pethidine
  • phenindamine
  • histidine
  • isoleucine
  • proline
  • lauric acid
  • lymecycline
  • hypromellose
  • abiraterone acetate and niraparib
  • ichthammol
  • levamisole
  • naftazone
  • nefopam
  • oxprenolol
  • oxybuprocaine
  • elranatamab-bcmm
  • lapyrium
  • isoaminile
  • iotrolan
  • mazindol
  • masoprocol
  • lypressin
  • meradimate
  • molsidomine
  • monobenzone
  • mequinol/gluconolactone/ lactobionic acid/ arbutin
  • medifoxamine
  • mebutamate
  • metergoline
  • methantheline
  • methdilazine
  • metocurine
  • micronomicin
  • metaraminol
  • mephenesin
  • menadione
  • medrysone
  • metixene
  • levobetaxolol
  • guaiacol glycerol ether
  • eucalyptol
  • sodium tetradecyl sulfate
  • sugammadex
  • carbetocin
  • certoparin
  • chlorcyclizine/pseudoephedrine
  • cephapirin
  • indecainide
  • iobitridol
  • iomeprol
  • chlorphenesin
  • msud analog
  • msud maxamum
  • iceland moss
  • glutethimide
  • hexachlorophene
  • haloprogin
  • deferoxamine
  • ethchlorvynol
  • dexpanthenol topical
  • etilefrine
  • deslanoside
  • carbocromen
  • diazolidinylurea
  • dibenzepin
  • etofamide
  • guanoxan
  • halazepam
  • guanadrel sulfate
  • dapiprazole
  • soapwort
  • debrisoquine
  • l-tryptophan
  • chlormerodrin
  • chlorquinaldol
  • cetrimonium
  • carbocisteine
  • chlorcyclizine/codeine
  • technetium Tc-99m tetrofosmin
  • technetium Tc-99m disofenin
  • technetium Tc-99m gluceptate
  • technetium Tc-99m labeled red blood cells
  • amylmetacresol/dextromethorphan hydrobromide
  • anileridine phosphate
  • pyrethrins
  • pyrantel pamoate
  • quinagolide
  • spiramycin
  • standard hyperkalemic cardioplegia solution
  • technetium tc-99m mertiatide
  • technetium tc-99m medronate
  • bemotrizinol / bisoctrizole
  • benfotiamine
  • bemotrizinol + titanium dioxide + zinc oxide
  • technetium Tc-99m oxidronate
  • technetium Tc-99m pentetate
  • technetium Tc-99m pyrophosphate
  • benziodarone
  • octinoxate/bisoctrizole
  • bicisate dihydrochloride
  • technetium Tc-99m bicisate
  • norelgestromin/ethinyl estradiol
  • norgestimate/ethinyl estradiol
  • ximelagatran (investigational)
  • xamoterol
  • trioxsalen
  • poly-urea urethane
  • rilmenidine
  • pemirolast
  • oxitriptan
  • beclomethasone, intranasal
  • thimerosal
  • camphor gel
  • camphor
  • mumps virus vaccine, live
  • rubella virus vaccine, live
  • aluminum chloride (dental)
  • alum irrigation
  • framycetin, phenylephrine, and gramicidin
  • ombitasvir, paritaprevir, ritonavir, and dasabuvir
  • olipudase alfa
  • etonogestrel/ethinyl estradiol
  • mycophenolate
  • fluoroestradiol F 18
  • donor organ cardioplegia solution
  • fluciclovine F 18
  • fusidic acid (ophthalmic)
  • fusidic acid and hydrocortisone
  • framycetin, dexamethasone, and gramicidin
  • fludeoxyglucose F-18
  • fluorouracil/salicylic acid
  • indium In-111 oxyquinoline
  • indium In-111 pentetreotide
  • indium In-111 capromab pendetide
  • lusutrombopag
  • mitomycin (ophthalmic)
  • mifepristone and misoprostol
  • minoxidil (systemic)
  • methyl aminolevulinate (topical)
  • methyl folate, methylcobalamin, and acetylcysteine
  • ciclesonide/formoterol/tiotropium
  • nedocromil (Oral Inhalation)
  • batefenterol (Investigational)
  • neostigmine and glycopyrrolate
  • nepafenac ophthalmic
  • netupitant/palonosetron
  • meperidine and promethazine
  • mepivacaine and levonordefrin
  • maltodextrin
  • medical cannabis
  • medium chain triglycerides
  • mometasone/glycopyrrolate (glycopyrronium)/ indacaterol
  • moxifloxacin ophthalmic
  • neomycin/fluocinolone
  • nadroparin
  • iodine I-125 iothalamate
  • amikacin liposome (oral inhalation)
  • bupivacaine liposome
  • natamycin
  • lopinavir and ritonavir
  • lysine
  • macitentan and tadalafil
  • mitomycin pyelocalyceal
  • moclobemide
  • mometasone and indacaterol
  • efinaconazole
  • blue-green algae
  • indocyanine green
  • follitropin beta
  • lumasiran
  • glycerin/lidocaine
  • edrophonium/atropine
  • indigo carmine
  • lutropin alfa
  • instant glucose/intravenous dextrose
  • iobenguane I-123
  • ixekizumab
  • isosulfan blue dye
  • levofloxacin ophthalmic
  • levonorgestrel oral/ferrous bisglycinate/ ethinylestradiol
  • ethinyl estradiol/levonorgestrel transdermal
  • hydroquinone
  • hydroxypropyl methylcellulose
  • icodextrin
  • lipid emulsion (soybean, medium-chain triglyceride, olive, and fish oils; [SMOF])
  • iodinated I 125 albumin
  • iodinated I 131 albumin
  • lipid emulsion (plant oil-based)
  • levonorgestrel intrauterine
  • levonorgestrel oral/ethinyl estradiol
  • lactic acid and sodium-PCA
  • lactated Ringer solution
  • ketotifen (systemic)
  • lanolin
  • leuprolide and norethindrone
  • levodopa and benserazide
  • gonadorelin acetate
  • hemodialysis solutions
  • nirsevimab-alip
  • gentian violet
  • gallium ga-68 dotatate
  • fusidic acid and betamethasone
  • gallium citrate Ga-67
  • gadopentetate dimeglumine
  • gadofosveset
  • follitropin delta
  • follitropin alfa and lutropin alfa
  • follitropin alfa
  • rocatinlimab
  • grass pollens allergen extract
  • flotufolastat F18
  • fluorescein ophthalmic
  • barium
  • balanced salt solution
  • air polymer type A intrauterine device
  • clodronate
  • bentoquatam
  • clobetasone
  • alfacalcidol
  • citric acid/glucono-delta-lactone/magnesium carbonate
  • benzoin
  • desirudin
  • immune globulin IV (IGIV)
  • dequalinium
  • pseudoephedrine/desloratadine
  • clofedanol
  • cyproterone and ethinyl estradiol
  • dextranomer and hyaluronic acid or derivatives
  • diatrizoate meglumine and diatrizoate sodium
  • glucosamine sulfate, chondroitin sulfate and Msm
  • squill
  • gotu kola
  • blessed thistle
  • bitter melon
  • apraclonidine
  • chlophedianol/dexbrompheniramine/pseudoephedrine
  • wild jujube
  • chitosan
  • cilazapril/hydrochlorothiazide
  • dexbrompheniramine and phenylephrine
  • diethylene triamine penta-acetic acid
  • dexchlorpheniramine and pseudoephedrine
  • lily of the valley
  • diflucortolone
  • corydalis
  • lemon balm
  • MSM
  • calcium polystyrene sulfonate
  • caprylidene
  • peppermint oil
  • efavirenz/lamivudine/tenofovir DF
  • emtricitabine/tenofovir DF /efavirenz
  • dutasteride/tamsulosin
  • milk thistle
  • centaury
  • horseweed
  • lycopus
  • agrimony
  • alfalfa
  • kava
  • cetrorelix
  • cetylpyridinium
  • chlophedianol and dexbrompheniramine
  • betahistine
  • choline C-11
  • boric acid vaginal suppository
  • aluminum acetate
  • aluminum chloride hexahydrate
  • 14-C urea breath test
  • absorbable collagen
  • valoctocogene roxaparvovec-rvox
  • amlodipine and celecoxib
  • aspirin and omeprazole
  • azilsartan and chlorthalidone
  • landiolol (Pending FDA approval)
  • isosorbide dinitrate/hydralazine
  • losartan/hydrochorothiazide
  • udenafil
  • dextromethorphan/quinidine
  • onasemnogene abeparvovec
  • orphenadrine/aspirin/caffeine
  • trace elements
  • sodium phenylbutyrate/ taurursodiol
  • fish oil triglycerides
  • infant formula
  • glutamine
  • chloroquine phosphate
  • afatinib
  • quinidine gluconate
  • methylergonovine
  • prothrombin complex concentrate, human
  • BCG intravesical live
  • capivasertib
  • cedazuridine
  • carbonyl iron
  • iron dextran complex
  • lovotibeglogene autotemcel (FDA Approval Pending)
  • sodium benzoate/sodium phenylacetate
  • mineral oil otic
  • zolmitriptan transdermal
  • midazolam intranasal
  • fosinopril/hydrochlorothiazide
  • caplacizumab
  • arginine
  • sodium phenylbutyrate
  • meloxicam/rizatriptan
  • manganese
  • acetaminophen/pamabrom/pyridoxine
  • varicella zoster immune globulin, human
  • amitriptyline/perphenazine
  • narsoplimab (Pending FDA Approval)
  • amlodipine/perindopril
  • imiglucerase
  • canagliflozin/metformin
  • tafamidis meglumine
  • somatrogon-ghla
  • glimepiride/rosiglitazone
  • becaplermin
  • lithium
  • loxapine inhaled
  • nicotine transdermal
  • tixagevimab and cilgavimab (Investigational)
  • muromonab CD3
  • ansuvimab
  • coal tar bath products
  • fibrin sealant
  • arimoclomol (FDA Approval Pending)
  • varenicline intranasal
  • aducanumab
  • oxycodone/naloxone
  • ritlecitinib
  • sodium polystyrene sulfonate
  • calcipotriene/betamethasone
  • calcium hydroxylapatite
  • cantharidin topical
  • doxepin cream
  • clocortolone
  • formaldehyde topical
  • sodium sulfide topical
  • collagenase
  • selegiline transdermal
  • foscarbidopa/foslevodopa (FDA approval pending)
  • saxagliptin/metformin
  • linagliptin/metformin
  • linzagolix (FDA approval pending)
  • efgartigimod/hyaluronidase SC
  • elamipretide (Pending FDA approval)
  • rozanolixizumab
  • diazoxide
  • glimepiride/pioglitazone
  • cipaglucosidase alfa
  • dihydroergotamine intranasal
  • delandistrogene moxeparvovec
  • beremagene geperpavec
  • hyaluronic acid and derivatives
  • hyaluronic acid, non-animal stabilized
  • eplontersen (FDA Approval Pending)
  • nitric oxide gas
  • sodium phenylbutyrate and taurursodiol
  • treprostinil SC
  • viltolarsen
  • albuterol/ipratropium
  • budesonide inhaled
  • budesonide rectal
  • palovarotene (FDA Approval Pending)
  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  • amino acids mixture
  • aminobenzoate potassium
  • elivaldogene autotemcel
  • naproxen and sumatriptan
  • sumatriptan intranasal
  • alglucerase
  • metformin/rosiglitazone
  • ertugliflozin/metformin
  • elosulfase alfa
  • calcium carbonate/magnesium hydroxide
  • starch suppository
  • abicipar pegol (FDA Approval Pending)
  • riboflavin 5′-phosphate ophthalmic
  • povidone ophthalmic
  • glycerin oropharyngeal
  • dimethicone topical
  • menthol topical, dimethicone topical
  • pramoxine topical, menthol topical and dimethicone topical
  • phosphorated carbohydrate
  • brilliant blue G ophthalmic
  • brolucizumab intravitreal
  • purified water, ophthalmic
  • hydroxyethyl cellulose ophthalmic
  • ranibizumab intravitreal implant
  • sodium chloride hypertonic, ophthalmic 
  • cetirizine ophthalmic
  • phentolamine ophthalmic
  • ganciclovir ophthalmic
  • triamcinolone intravitreal
  • ocriplasmin intravitreal
  • atoltivimab/maftivimab/odesivimab
  • pegcetacoplan intravitreal
  • triamcinolone acetonide extended-release injectable suspension
  • tobramycin/loteprednol ophthalmic
  • 2-octyl cyanoacrylate
  • vitamins A & D topical
  • diphenhydramine/allantoin topical
  • pyrethrins/piperonyl butoxide
  • lodoxamide ophthalmic
  • obeticholic acid
  • fluocinolone intravitreal implant
  • sincalide
  • linaclotide
  • nedocromil ophthalmic
  • cysteamine ophthalmic
  • avacincaptad pegol intravitreal
  • azelastine ophthalmic
  • bacitracin ophthalmic
  • propylene glycol ophthalmic
  • rimexolone ophthalmic
  • metoclopramide intranasal
  • mirikizumab (FDA approval pending)
  • netarsudil ophthalmic
  • cenegermin
  • dexamethasone ophthalmic insert
  • prednisolone ophthalmic
  • phenylephrine and cocoa butter rectal
  • phenylephrine and witch hazel topical
  • phenylephrine, pramoxine, glycerin and petrolatum rectal
  • bisacodyl rectal
  • aluminum hydroxide/magnesium carbonate
  • aluminum hydroxide/magnesium hydroxide
  • hyoscyamine spray
  • methenamine/methylene blue/ hyoscyamine/ sodium phosphate monobasic/ phenyl salicylate
  • phenylephrine
  • chlorophyll
  • castor oil
  • cholic acid
  • phenol oropharyngeal
  • articaine/epinephrine
  • antithymocyte globulin equine
  • aluminum hydroxide/magnesium trisilicate
  • methenamine/hyoscyamine
  • hydrocortisone topical/pramoxine topical 
  • sodium fluoride topical
  • mesna
  • C1 esterase inhibitor recombinant
  • menthol and pectin
  • menthol oropharyngeal
  • pectin oropharyngeal
  • gepirone
  • Goldenseal
  • polyethylene glycol and electrolytes
  • polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid
  • brompheniramine/pseudoephedrine/dextromethorphan
  • brompheniramine phenylephrine
  • acetaminophen/doxylamine/phenylephrine
  • doxylamine/acetaminophen/pseudoephedrine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan/phenylephrine
  • eslicarbazepine
  • fluticasone and salmeterol
  • codeine, acetaminophen, butalbital and caffeine
  • codeine, chlorpheniramine and phenylephrine
  • iodine
  • povidone iodine
  • butalbital/aspirin/caffeine/codeine
  • polyethylene glycol 400/propylene glycol ophthalmic 
  • pegvaliase
  • amivantamab
  • iopamidol
  • codeine and pseudoephedrine
  • emtricitabine, rilpivirine, tenofovir DF
  • penicillin G aqueous
  • miconazole topical
  • miconazole vaginal
  • ciprofloxacin inhaled (Pending FDA approval)
  • ceftazidime/avibactam
  • ceftolozane/​tazobactam
  • aztreonam inhalation
  • amphotericin B cholesteryl sulfate
  • miconazole oral
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF
  • isavuconazonium sulfate
  • dapivirine intravaginal (FDA Approval Pending)
  • lamivudine/raltegravir
  • codeine/triprolidine/pseudoephedrine
  • cadexomer iodine
  • brompheniramine/pseudoephedrine
  • codeine/acetaminophen
  • codeine/guaifenesin
  • beclomethasone inhaled
  • epoetin beta/methoxy polyethylene glycol
  • voreloxin(Orphan Drug)
  • rociletinib
  • pitcher plant
  • phosphatidylserine
  • telotristat ethyl
  • copper CU 64 dotatate
  • urea topical
  • exenatide subdermal implant
  • asenapine transdermal
  • ethiodized oil
  • urea oral
  • miglustat
  • acalisib(Investigational)
  • acetophenazine
  • guggul
  • aceneuramic acid
  • mestranol/norethindrone
  • reishi
  • lactitol
  • vonoprazan fumarate
  • motherwort
  • silver nitrate
  • salicylic acid/sulfur shampoo
  • salicylic acid topical
  • ketorolac ophthalmic
  • ketoconazole topical
  • Japanese encephalitis virus vaccine
  • dibucaine topical ointment
  • ketorolac intranasal
  • ketorolac/phenylephrine ophthalmic
  • rotavirus oral vaccine, live
  • guarana
  • hops
  • krill oil
  • salicylic acid/coal tar shampoo
  • sufentanil SL
  • pancrelipase
  • passion flower
  • pepdite one plus
  • nivolumab and relatlimab
  • relatlimab (Pending FDA Approval)
  • benzalkonium chloride/benzocaine
  • ketotifen, drug-eluting contact lens
  • calcitriol topical
  • oxymetazoline topical
  • alclometasone topical
  • capsaicin topical
  • diclofenac/misoprostol
  • diclofenac ophthalmic
  • diclofenac topical
  • pramoxine/calamine topical
  • veverimer
  • tolazoline
  • olopatadine ophthalmic
  • lutetium lu 177-dota-tate
  • lutetium lu 177 vipivotide tetraxetan
  • strontium 89 chloride
  • interferon alfa n3
  • lutetium Lu 177- Diethylenetriamine Pentaacetic acid-omburtamab (FDA Approval Pending)
  • samarium sm 153 lexidronam
  • cytomegalovirus immune globulin (CMV IG)
  • antithymocyte globulin rabbit
  • inolimomab (Pending FDA Approval)
  • olopatadine intranasal
  • olopatadine intranasal/​mometasone, intranasal
  • benzocaine/butamben/tetracaine topical
  • antipyrine/benzocaine/phenylephrine
  • dyclonine/menthol
  • surufatinib
  • fruquintinib
  • tepotinib 
  • dostarlimab
  • hepatitis B immune globulin (HBIG)
  • remestemcel-L
  • benzocaine/menthol oropharyngeal
  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • human rabies immune globulin (HRIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-htp
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
  • brinzolamide/brimonidine
  • betamethasone topical
  • omaveloxolone
  • bardoxolone
  • allogeneic processed thymus tissue
  • fluocinolone topical
  • tacrolimus topical
  • ruxolitinib topical
  • pimecrolimus topical
  • sofosbuvir, velpatasvir and voxilaprevir
  • sofosbuvir/velpatasvir
  • mitotane
  • elbasvir/​grazoprevir
  • wheat dextrin
  • vanadium
  • iron/folic acid/vitamin/mineral
  • molybdenum
  • sparsentan
  • velmanase alfa-tycv
  • pegcetacoplan
  • ferrous sulfate
  • cyclosporine ophthalmic
  • ferric pyrophosphate
  • ammonium lactate
  • etelcalcetide
  • iodoquinol
  • sucroferric oxyhydroxide
  • doxercalciferol
  • terconazole vaginal
  • cortisone
  • pyronaridine
  • tetrahydrozoline, ophthalmic
  • tenapanor
  • tesamorelin
  • benazepril/hydrochlorothiazide
  • nadolol and bendroflumethiazide
  • spironolactone and hydrochlorothiazide
  • COVID-19 Vaccine, mRNA
  • atosiban
  • bisoprolol and hydrochlorothiazide
  • ephedrine/guaifenesin
  • clonidine/chlorthalidone
  • captopril/hydrochlorothiazide
  • amlodipine/valsartan/hydrochlorothiazide
  • hydrochlorothiazide and irbesartan
  • candesartan/hydrochlorothiazide
  • ciclesonide intranasal
  • cromolyn sodium ophthalmic
  • methyldopa/hydrochlorothiazide
  • valsartan/hydrochlorothiazide
  • hydrochlorothiazide and triamterene
  • moexipril/hydrochlorothiazide
  • mometasone/intranasal
  • ofloxacin ophthalmic
  • cysteamine
  • metoprolol/hydrochlorothiazide
  • amlodipine/olmesartan
  • eprosartan/hydrochlorothiazide
  • amlodipine/telmisartan
  • hydrochlorothiazide/aliskiren
  • betamethasone/clotrimazole
  • telmisartan/hydrochlorothiazide
  • benazepril/amlodipine
  • bezlotoxumab
  • propranolol/hydrochlorothiazide
  • bupropion/naltrexone
  • burosumab
  • acetylcholine chloride intraocular solution
  • bupivacaine and meloxicam
  • budesonide and formoterol (inhalation)
  • valerian
  • entacapone/levodopa/carbidopa
  • carbidopa/levodopa
  • calaspargase pegol
  • cabotegravir
  • cefixime
  • calfactant
  • brinzolamide
  • daprodustat
  • brimonidine and timolol
  • brodalumab
  • buprenorphine and naloxone
  • hydrocortisone acetic acid otic
  • butorphanol
  • butoconazole
  • adapalene and benzoyl peroxide
  • acrivastine and pseudoephedrine
  • neomycin/polymyxin B/bacitracin topical
  • midodrine
  • baloxavir marboxil
  • bacitracin, neomycin, polymyxin B, and hydrocortisone topical
  • avatrombopag
  • glucagon
  • atenolol/chlorthalidone
  • adefovir
  • activated charcoal
  • avalglucosidase alfa
  • aclidinium and formoterol
  • iclaprim (Pending FDA Approval)
  • ampicillin/sulbactam
  • quinupristin/dalfopristin
  • lamivudine/zidovudine/abacavir
  • acetaminophen and caffeine
  • acetaminophen/pamabrom
  • abacavir and lamivudine
  • anifrolumab
  • elacestrant
  • anidulafungin
  • acetohydroxamic acid
  • alogliptin/pioglitazone
  • anthralin
  • pirtobrutinib
  • gabapentin
  • galsulfase
  • gadoterate meglumine
  • ferric gluconate
  • ferric derisomaltose
  • ethanolamine oleate
  • eteplirsen
  • vasopressin
  • desmopressin
  • meropenem/vaborbactam
  • ecallantide
  • econazole topical
  • dornase alfa
  • aspirin/dipyridamole
  • dipyridamole
  • difenoxin and atropine
  • diflorasone
  • difluprednate ophthalmic
  • eptinezumab
  • diethylpropion
  • dexchlorpheniramine
  • dexmethylphenidate
  • serdexmethylphenidate/​dexmethylphenidate
  • bexagliflozin
  • galcanezumab
  • fremanezumab
  • tapinarof topical
  • darifenacin
  • dalbavancin
  • darbepoetin alfa
  • azilsartan
  • colestipol
  • corticorelin
  • crotamiton
  • crofelemer
  • allogeneic cultured keratinocytes/fibroblasts in bovine collagen
  • tapentadol
  • cyclopentolate
  • polymyxin B/bacitracin topical
  • tavaborole
  • tagraxofusp
  • crisaborole
  • crizanlizumab
  • satralizumab
  • spinosad
  • sacubitril/valsartan
  • sargramostim
  • sebelipase alfa
  • regadenoson
  • ribociclib/letrozole
  • ragweed allergen extract
  • radium-223 dichloride
  • secnidazole
  • setmelanotide
  • polycarbophil
  • plecanatide
  • sacituzumab govitecan
  • pertuzumab
  • pertuzumab/trastuzumab/hyaluronidase
  • pamidronate
  • halcinonide
  • glecaprevir/​pibrentasvir
  • glucarpidase
  • golodirsen
  • dextrose (antidote)
  • hexaminolevulinate
  • iohexol
  • ferric citrate
  • elapegademase
  • emicizumab
  • erenumab
  • danaparoid
  • dantrolene
  • eflapegrastim
  • edaravone
  • amcinonide
  • carglumic acid
  • alcaftadine ophthalmic
  • agalsidase beta
  • afamelanotide
  • fosdenopterin
  • lidocaine and chlorhexidine
  • levorphanol
  • calcifediol
  • factor VIIa, recombinant
  • triheptanoin
  • peanut oral allergen powder
  • teprotumumab
  • poly-L-lactic acid/carboxymethylcellulose/mannitol
  • xenon Xe 129 hyperpolarized
  • ublituximab
  • anacaulase
  • glatiramer
  • peginterferon beta-1a
  • interferon beta-1a
  • onabotulinumtoxinA
  • cycloserine
  • ethionamide
  • cabotegravir and rilpivirine
  • vericiguat
  • omidenepag isopropyl
  • azelastine/fluticasone intranasal
  • benzyl peroxide
  • vutrisiran
  • brimonidine
  • testosterone topical
  • lenacapavir
  • tebentafusp
  • mosunetuzumab
  • faricimab
  • ganirelix
  • nadofaragene firadenovec
  • ozenoxacin
  • guaifenesin
  • adagrasib
  • guselkumab
  • adalimumab-aacf
  • nonoxynol-9
  • nifurtimox
  • nusinersen
  • nitazoxanide
  • mavacamten
  • calcipotriene
  • bimatoprost
  • obinutuzumab
  • amifostine
  • oxycodone/​aspirin
  • oxycodone/ibuprofen
  • oteseconazole
  • oxychlorosene
  • porfimer
  • pramoxine /hydrocortisone topical
  • podofilox
  • quinapril/hydrochlorothiazide
  • acetaminophen/pamabrom/pyrilamine
  • levobunolol
  • paregoric
  • idursulfase
  • lesinurad and allopurinol
  • latanoprost/​netarsudil ophthalmic
  • lactase enzyme
  • bioadherent oral
  • latanoprost and timolol
  • latanoprostene bunod
  • ledipasvir/sofosbuvir
  • imipenem/cilastatin/relebactam
  • imipenem/cilastatin
  • hemin
  • deucravacitinib
  • house dust mite allergen extract
  • halobetasol topical/tazarotene
  • remimazolam
  • somatropin
  • remifentanil
  • ethotoin
  • etidronate
  • empagliflozin, linagliptin, and metformin
  • elvitegravir/cobicistat/emtricitabine/tenofovir AF
  • empagliflozin/metformin
  • evinacumab
  • finasteride and tadalafil
  • flortaucipir (18F)
  • proparacaine/ fluorescein ophthalmic
  • fluorescein/benoxinate ophthalmic
  • fluphenazine
  • alogliptin/​metformin
  • alogliptin/pioglitazone
  • alitretinoin topical
  • dextrose/ sodium citrate/fructose
  • dasabuvir
  • ombitasvir​/paritaprevir/​ritonavir
  • hydrocodone/​chlorpheniramine/​pseudoephedrine
  • hydroxyamphetamine/​tropicamide
  • acamprosate
  • gadobutrol
  • teclistamab
  • tremelimumab
  • futibatinib
  • etranacogene dezaparvovec
  • olutasidenib
  • naproxen and diphenhydramine
  • naratriptan
  • gadopiclenol
  • gadoxetate
  • gadoversetamide
  • naphazoline/pheniramine
  • naphazoline
  • nalbuphine
  • vosoritide
  • vitamin K1 (phytonadione)
  • moxidectin
  • basiliximab
  • fecal microbiota, live-jslm
  • ibuprofen/famotidine
  • famotidine
  • raxibacumab
  • omalizumab
  • measles, mumps, rubella, and varicella vaccine, live (Rx)
  • senna/docusate
  • dinoprostone
  • measles mumps and rubella vaccine, live
  • immune globulin IM (IGIM)
  • dyclonine
  • doravirine, lamivudine, and tenofovir disoproxil fumarate
  • elexacaftor/tezacaftor/ivacaftor
  • ivacaftor/tezacaftor
  • treosulfan
  • tranexamic acid
  • norethindrone acetate/​estradiol/​elagolix
  • artesunate
  • trientine
  • trifarotene
  • ziconotide
  • vonoprazan/amoxicillin/clarithromycin
  • pyrithione zinc
  • zinc oxide topical
  • naphazoline/​zinc sulfate/​glycerin ophthalmic
  • voretigene neparvovec
  • nirmatrelvir/ritonavir
  • bebetelovimab
  • sodium chloride
  • relugolix/​estradiol/​norethindrone
  • defibrotide
  • prothionamide
  • liraglutide/insulin degludec
  • etilfrine
  • alpha-lipoic acid
  • ramosetron
  • olodaterol/tritropium
  • cimetropium
  • umeclidinium
  • itopride
  • secretin
  • naftopidil
  • trimeprazine
  • benperidol
  • chlormethiazole
  • multivitamins
  • secukinumab
  • glycopyrrolate inhaled and formoterol
  • amitriptyline and chlordiazepoxide
  • tirzepatide
  • relugolix/estradiol/norethindrone
  • mupirocin
  • alvimopan
  • chlordiazepoxide
  • insulin regular human
  • insulin aspart protamine/​insulin aspart
  • insulin isophane human/​insulin regular human
  • insulin degludec/insulin aspart
  • teplizumab
  • chlordiazepoxide/clidinium
  • aspirin, sodium bicarbonate, and citric acid
  • aluminum hydroxide, magnesium hydroxide, and simethicone
  • glycopyrrolate inhaled
  • olodaterol/tiotropium
  • umeclidinium bromide
  • timolol/dorzolamide
  • travoprost ophthalmic
  • loxapine
  • eptifibatide
  • hydrocodone/acetaminophen
  • omega 3 fatty acids
  • trandolapril/​verapamil
  • abciximab
  • artificial saliva
  • diphtheria, hepatitis B, pertussis (acellular), polio, and tetanus vaccine
  • diphtheria, haemophilus B, pertussis, polio, tetanus vaccine
  • haemophilus influenzae type b vaccine/hepatitis b vaccine
  • butalbital/aspirin/caffeine 
  • colchicine/probenecid
  • atovaquone and proguanil
  • ursodiol
  • chenodiol
  • casirivimab/imdevimab
  • tixagevimab/cilgavimab
  • molnupiravir
  • bebtelovimab
  • calcium, magnesium, potassium and sodium oxybate
  • sodium oxybate
  • diphtheria, polio, pertussis acellular, tetanus vaccine
  • pseudoephedrine loratadine
  • sodium chloride nasal
  • hydroxychloroquine sulfate
  • atorvastatin and ezetimibe
  • teriparatide
  • alendronate and cholecalciferol
  • alprostadil (IV)
  • romosozumab
  • risedronate
  • alendronate
  • glyburide/metformin
  • clorazepate
  • rosuvastatin/​ezetimibe
  • paclitaxel/encequidar
  • valsartan/amlodipine
  • enalapril/hydrochlorothiazide
  • enalapril and felodipine
  • amiloride/hydrochlorothiazide
  • triamterene/hydrochlorothiazide
  • lisinopril/hydrochlorothiazide
  • tegaserod
  • rhein
  • ritanserin
  • sulfaphenazole
  • sulconazole
  • taurursodiol
  • bromeperidol
  • carbapenems
  • fotemustine
  • difelikefalin
  • bromopride
  • alizapride
  • olopatadine
  • oxomemazine
  • paraldehyde
  • oxcarbazepine
  • kratom
  • elexacaftor
  • oritavancin
  • miocamycin
  • curcumin sulfate
  • seproxetine
  • clotrimazole
  • remacemide
  • piperine
  • ditiocarb
  • danoprevir
  • oxetacaine
  • topiroxostat
  • indisulam
  • tofisopam
  • noscapine
  • thiopental
  • tioconazole
  • nicotinamide
  • rutin
  • mequitazine
  • somatostatin
  • vapreotide
  • econazole
  • saracatinib
  • lestaurtinib
  • efonidipine
  • zimelidine
  • indalpine
  • desvenlafaxine
  • benidipine
  • dapoxetine
  • tesmilifene
  • pergolide
  • sitaxentan
  • resveratrol
  • bifonazole
  • tildipirosin
  • solithromycin
  • selamectin
  • imiquimod topical
  • fluorouracil topical
  • peginterferon alfa-2b
  • interferon alfa-2b
  • alteplase
  • tanshinone I
  • rosmarinic acid
  • caryophyllene
  • ursolic acid
  • cepharanthine
  • veliflapon
  • mirikizumab
  • cp-96345
  • famprofazone
  • peoniflorin
  • fepradinol
  • licofelone
  • polmacoxib
  • ebselen
  • taxifolin
  • betulinic acid
  • flurbiprofen axetil
  • talniflumate
  • morniflumate
  • nitroaspirin
  • firocoxib
  • ns-398
  • cimicoxib
  • robenacoxib
  • sc-236
  • imidazole salicylate
  • trolamine salicylate
  • pirprofen
  • benorilate
  • ethenzamide
  • mofebutazone
  • proquazone
  • carbaspirin calcium
  • guacetisal
  • proglumetacin
  • propyphenazone
  • pranoprofen
  • bendazac
  • tenidap
  • lonazolac
  • nifenazone
  • flunoxaprofen
  • difenpiramide
  • feprazone
  • bufexamac
  • alminoprofen
  • suxibuzone
  • fentiazac
  • tinoridine
  • tepoxalin
  • indobufen
  • flunixin
  • propacetamol
  • clonixin
  • droxicam
  • epirizole
  • etofenamate
  • ibuproxam
  • indoprofen
  • kebuzone
  • felbinac
  • zaltoprofen
  • azapropazone
  • zomepirac
  • niflumic acid
  • magnesium salicylate
  • suprofen
  • nepafenac
  • bromfenac
  • ciprofloxacin and hydrocortisone (otic) (Rx)
  • hydrocortisone/neomycin/polymyxin otic (Rx)
  • vigabatrine
  • valproate sodium injection
  • tezepelumab (Rx)
  • triamcinolone acetonide/nystatin
  • triamcinolone suprachoroidal (Rx)
  • triamcinolone, intranasal
  • ciclesonide inhaled
  • diosmin
  • tirbanibulin
  • padeliporfin
  • roxadustat
  • aminosalicylic acid
  • rasburicase
  • tetracaine
  • articaine
  • ropivacaine
  • nitrous oxide
  • sulfapyridine
  • sulfanilamide
  • mafenide
  • isometheptene
  • amyl nitrite
  • antipyrine
  • isosorbide dinitrate
  • prilocaine
  • nitroglycerin
  • tobacco
  • batefenterol
  • hexoprenaline
  • pf-00610355
  • racepinephrine
  • protokylol
  • doxofylline
  • phenylpropanolamine
  • isoetharine
  • ephedra sinica root
  • dipivefrin
  • arbutamine
  • norepinephrine
  • fenoterol
  • clenbuterol
  • pirbuterol
  • epinephrine
  • ritodrine
  • procaterol
  • orciprenaline
  • bitolterol
  • abediterol
  • fluticasone furoate, umeclidinium and vilanterol
  • fluticasone furoate and vilanterol
  • mometasone and formoterol
  • pramoxine topical (OTC)
  • menthol/pramoxine (topical)
  • tetrastarch
  • plasma protein fraction
  • hetastarch
  • rokitamycin
  • ridaforolimus
  • oleandomycin
  • patupilone
  • mitemcinal
  • midecamycin
  • mirvetuximab soravtansine
  • lorvotuzumab mertansine
  • kitasamycin
  • flurithromycin
  • eprinomectin
  • epofolate
  • epothilone D
  • coltuximab ravtansine
  • dirithromycin
  • doramectin
  • cethromycin
  • carbomycin
  • paramethasone
  • dexamethasone isonicotinate
  • quinupristin
  • sarilumab
  • dalfopristin
  • curcumin
  • luliconazole
  • procaine
  • chloroprocaine
  • phencyclidine
  • tenocyclidine
  • profenamine
  • halothane
  • lfenprodil
  • calcium levulinate
  • agmatine
  • calcium pangamate
  • calcium glubionate
  • edodekin alfa
  • beloranib
  • aflibercept
  • endostar
  • volociximab
  • roquinimex
  • anecortave acetate
  • squalamine
  • brolucizumab
  • trebananib
  • semaxanib
  • endostatin
  • halofuginone
  • resveratol
  • ranibizumab
  • fumagilin
  • bevacizumab
  • hyperforin
  • aminohippuric acid
  • opicapone
  • pafolacianine
  • bempedoic acid
  • belantamab mafodotin
  • prasterone
  • glecaprevir
  • levomenol
  • parachlorophenol
  • gadoxetic acid
  • cholecystokinin
  • caspofungin
  • ouabain
  • rifampicin
  • taurocholic acid
  • methylphosphinic acid
  • revefenacin
  • isoprenaline
  • posiphen
  • acotiamide
  • triflupromazine
  • pegvisomant
  • pipecuronium
  • regramostim
  • phenserine
  • diethylcarbamazine
  • cinchocaine
  • pancuronium
  • bambuterol
  • hexafluronium
  • aprotinin
  • tyrothricin
  • decamethonium
  • ipidacrine
  • tubocurarine
  • paraoxon
  • ginkgo biloba
  • methanesulfonyl fluoride
  • dichlorvos
  • fenthion
  • metrifonate
  • coumaphos
  • huperzine A
  • distigmine
  • neostigmine
  • isoflurophate
  • tasosartan
  • fimasartan
  • methylthioninium
  • minaprine
  • gallamine triethiodide
  • ambenonium
  • abiraterone
  • mibefradil
dexmedetomidine + 

diphenoxylate/atropine

may enhance the CNS depressant effect

phenobarbital

may enhance the CNS depressant effect

diphenhydramine

may enhance the CNS depressant effect

midazolam

may enhance the CNS depressant effect

sufentanil

may enhance the CNS depressant effect

diazepam

may increase the CNS depressant effect of CNS Depressants

methadone

may increase the CNS depressant effect of CNS Depressants

secobarbital

may increase the CNS depressant effect of CNS Depressants

apomorphine

may have an increased CNS depressant effect when combined with dexmedetomidine

flurazepam

may have an increased CNS depressant effect when combined with dexmedetomidine

perphenazine

may have an increased CNS depressant effect when combined with dexmedetomidine

clorazepic acid

may have an increased CNS depressant effect when combined with dexmedetomidine

isoflurane

may have an increased CNS depressant effect when combined with dexmedetomidine

promazine

may have an increased CNS depressant effect when combined with dexmedetomidine

carvedilol

may have an increased AV-blocking effect when combined with beta-blockers

methylphenidate

dexmedetomidine: they may increase the CNS depressant effect of CNS stimulants

viloxazine

dexmedetomidine: they may increase the CNS depressant effect of CNS stimulants

cocaine

dexmedetomidine: they may increase the CNS depressant effect of CNS stimulants

opium tincture 

may enhance the CNS depressant effect

paregoric 

may increase the CNS depressant effect

levorphanol 

may increase the CNS depressant effect

risperidone 

may increase the CNS depressant effect of CNS depressants

eszopiclone 

may increase the CNS depressant effect of CNS depressants

acrivastine and pseudoephedrine 

may increase the CNS depressant effect of CNS depressants

brimonidine and timolol 

may increase the AV-blocking effect of beta blockers

flibanserin 

may increase the CNS depressant effect of CNS depressants

carbinoxamine 

may increase the CNS depressant effect of CNS depressants

molindone 

may increase the CNS depressant effect of CNS depressants

methohexital 

may increase the CNS depressant effect of CNS depressants

thiothixene 

may increase the CNS depressant effect of CNS depressants

desflurane 

may increase the CNS depressant effect of CNS depressants

fexofenadine 

may increase the CNS depressant effect of CNS depressants

promethazine/dextromethorphan 

may increase the CNS depressant effect of CNS Depressants

phenobarbital 

may increase the CNS depressant effect of CNS Depressants

sevoflurane 

may increase the CNS depressant effect of CNS Depressants

aripiprazole 

may increase the CNS depressant effect of CNS Depressants

suvorexant 

may increase the CNS depressant effect of CNS Depressants

buprenorphine buccal 

may increase the CNS depressant effect of CNS Depressants

buprenorphine,long-acting injection 

may increase the CNS depressant effect of CNS Depressants

imipramine

They may increase the vasopressor effect when combined with Alpha-/Beta-Agonists

protriptyline

They may increase the vasopressor effect when combined with Alpha-/Beta-Agonists

trimipramine

They may increase the vasopressor effect when combined with Alpha-/Beta-Agonists

benzylpenicilloyl polylysine 

It may decrease the diagnostic effect when combined with Alpha-/Beta-Agonists

chlorzoxazone 

may increase the CNS depressant effect of CNS Depressants

acetaminophen/doxylamine/dextromethorphan 

may increase the CNS depressant effect CNS Depressants

protriptyline

may decrease the antihypertensive effect when combined with alpha2-agonists

methylergometrine 

may increase the vasoconstricting effect of Ergot Derivatives

rasagiline 

may increase the adverse effect of Monoamine Oxidase Inhibitors

lisuride 

It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists

levalbuterol

may enhance the AV-blocking effect of beta-blockers

acebutolol

may enhance the AV-blocking effect of beta-blockers

penbutolol

may enhance the AV-blocking effect of beta-blockers

pindolol

may enhance the AV-blocking effect of beta-blockers

propranolol

may enhance the AV-blocking effect of beta-blockers

levalbuterol

may increase the effect of beta-blockers

acebutolol

may increase the effect of beta-blockers

penbutolol

may increase the effect of beta-blockers

pindolol

may increase the effect of beta-blockers

propranolol

may increase the effect of beta-blockers

propranolol

may increase the effect of beta-blockers

mirabegron

may increase the AV-blocking effect

penbutolol

may increase the AV-blocking effect

timolol

may increase the AV-blocking effect

betaxolol

may increase the AV-blocking effect

bisoprolol

may increase the AV-blocking effect

phenylbutazone 

It may enhance the risk of nephrotoxicity when combined with phenylbutazone

nylidrin 

may enhance the risk or severity of hypertension when combined

desvenlafaxine

may decrease the therapeutic effect when combined with Alpha2-Agonists

duloxetine

may decrease the therapeutic effect when combined with Alpha2-Agonists

levomilnacipran

may decrease the therapeutic effect when combined with Alpha2-Agonists

milnacipran

may decrease the therapeutic effect when combined with Alpha2-Agonists

nefazodone

may decrease the therapeutic effect when combined with Alpha2-Agonists

oracit

may increase the serum concentration

shohls Solution

may increase the serum concentration

sodium lactate

may increase the serum concentration

sodium citrate

may increase the serum concentration

sodium bicarbonate

may increase the serum concentration

vasopressin 

It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists

spironolactone 

It may decrease the vasoconstricting effect when combined with Alpha-/Beta-Agonists

pergolide 

It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists

clozapine 

It may decrease the therapeutic effect when combined with Alpha-/Beta-Agonists

kava 

may increase the effects of pharmacodynamic synergism

topiramate

it increases the effect of CNS depressants

 

Dosage Forms & Strengths 

injectable solution 

Glass vial with a single dosage of 200mcg/2mL (100mcg/mL).  

Further dilution is required before administration 

Sublingual film 

180mg 

120mg 

injectable solution ready-to-use 

0.9% NaCl 1000mcg/250mL (4mcg/mL) 

0.9% NaCl 400mcg/100mL (4mcg/mL) 

0.9% NaCl 200mcg/50mL (4mcg/mL) 

0.9% NaCl 80mcg/20mL (4mcg/mL) 

Procedural Sedation 

Loading dose: 1 mcg/kg Intravenous over 10 mins
Maintenance dose: 0.6 mcg/kg/hr Intravenous titrate to effect (generally 0.2 to 1 mcg/kg/hr)
fiberoptic intubation while Awake
Loading dose: 1 mcg/kg Intravenous over 10 mins
Maintenance dose: 0.7 mcg/kg/hr Intravenous till endotracheal tube is secured



Schizophrenia 

Mild/moderate
120 mcg Sublingual or buccal initially
If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 240 mcg/day
Severe
180 mcg Sublingual or buccal initially
If the agitation continues, administer 90 mcg in two doses at least 2 hours apart; do not exceed more than 360 mcg/day



Dose Adjustments

Dosage Modifications
Intravenous:
Consider lowering the dosage in individuals with hepatic impairment and those over 65 yrs of age; clearance declines with increasing severity of the hepatic impairment
Renal impairment: Dose adjustment is not required
Sublingual or buccal:
Renal impairment
dose adjustment is not necessary
Hepatic impairment
Mild/moderate (Child-Pugh score A or B)
Mild/moderate agitation: 90 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 210 mcg/day
Severe agitation: 120 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 240 mcg/day
Severe (Child-Pugh score C)
Mild/moderate agitation: 60 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 180 mcg/day
Severe agitation: 90 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 210 mcg/day

 

Dosage Forms & Strengths 

injectable solution 

Glass vial with a single dosage of 200mcg/2mL (100mcg/mL).  

Further dilution is required before administration 

Sublingual film 

180mg 

120mg 

injectable solution ready-to-use 

0.9% NaCl 1000mcg/250mL (4mcg/mL) 

0.9% NaCl 400mcg/100mL (4mcg/mL) 

0.9% NaCl 200mcg/50mL (4mcg/mL) 

0.9% NaCl 80mcg/20mL (4mcg/mL) 

Procedural Sedation 

Less than 1 month: Safety & efficacy were not established
Sedation is initiated during non-invasive procedures
1 month to less than 2 yrs: 1.5 mcg/kg intravenous loading infusion; infuse for 10 minutes
2 yrs to less than 18 yrs: 2 mcg/kg intravenous loading infusion; infuse for 10 minutes
if clinically indicated, Consider lowering dose
Sedation should be maintained throughout non-invasive procedures
1 month to less than 18 yrs: 1.5 mcg/kg/hr intravenous initially; titrate inorder to achieve a desired clinical effect within a dose range of about 0.5 to 1.5 mcg/kg/hr



 

Dosage Forms & Strengths 

injectable solution 

Glass vial with a single dosage of 200mcg/2mL (100mcg/mL).  

Further dilution is required before administration 

Sublingual film 

180mg 

120mg 

injectable solution ready-to-use 

0.9% NaCl 1000mcg/250mL (4mcg/mL) 

0.9% NaCl 400mcg/100mL (4mcg/mL) 

0.9% NaCl 200mcg/50mL (4mcg/mL) 

0.9% NaCl 80mcg/20mL (4mcg/mL) 

Procedural Sedation 

Loading dose: 1 mcg/kg Intravenous over 10 mins
Maintenance dose: 0.6 mcg/kg/hr Intravenous titrate to effect (generally 0.2 to 1 mcg/kg/hr)
fiberoptic intubation while Awake
Loading dose: 1 mcg/kg Intravenous over 10 mins
Maintenance dose: 0.7 mcg/kg/hr Intravenous till endotracheal tube is secured



Schizophrenia 

Mild/moderate
120 mcg Sublingual or buccal initially
If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 240 mcg/day



Dose Adjustments

Dosage Modifications
Intravenous:
Consider lowering the dosage in individuals with hepatic impairment and those over 65 yrs of age; clearance declines with increasing severity of the hepatic impairment
Renal impairment: Dose adjustment is not required
Sublingual or buccal:
Renal impairment
dose adjustment is not necessary
Hepatic impairment
Mild/moderate (Child-Pugh score A or B)
Mild/moderate agitation: 90 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 210 mcg/day
Severe agitation: 120 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 240 mcg/day
Severe (Child-Pugh score C)
Mild/moderate agitation: 60 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 180 mcg/day
Severe agitation: 90 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 210 mcg/day

Frequency defined 

1-10% 

Pyrexia (4-5%) 

Dry mouth (3-4%) 

Hypoxia (2-4%) 

Atelectasis (3%) 

Postprocedural hemorrhage (2-3%) 

Agitation (2%) 

Pain (2%) 

Chills or rigors (2%) 

Oliguria (2%)
Acidosis (1-2%) 

Pulmonary edema (1%) 

decreased Urine output (1%) 

Bradycardia (5-7%) 

Atrial fibrillation (4%) 

Vomiting (3-4%) 

Hypovolemia (3%) 

Tachycardia (2-3%) 

Anemia (2-3%) 

Hyperthermia (2%) 

Hyperglycemia (2%) 

Thirst (2%) 

Pleural effusion (1-2%) 

Hypocalcemia (1%) 

Sinus tachycardia (1%)  

>10% 

Hypertension (12-16%) 

Hypotension (25-28%) 

Nausea (9-11%)  

<1% 

Wheezing 

Ventricular tachycardia 

Peripheral edema  

Post marketing Reports 

Cardiac disorders: atrial fibrillation, bradycardia, cardiac disorder, myocardial infarction, tachycardia, ventricular tachycardia, Arrhythmia, atrioventricular block, cardiac arrest, extrasystoles, supraventricular tachycardia, ventricular arrhythmia 

Gastrointestinal disorders: diarrhea, vomiting, Abdominal pain, nausea 

Investigations: increased blood alkaline phosphatase, EKG T wave inversion, QT prolonged, increased AST/ALT, increased blood urea, increased GGT 

Nutrition and Metabolism disorders: hyperkalemia, hypovolemia, Acidosis, hypoglycemia, hypernatremia 

Psychiatric disorders: confusional state, hallucination, Agitation, delirium, illusion 

Respiratory, mediastinal, and thoracic disorders: bronchospasm, hypercapnia, hypoxia, respiratory acidosis, Apnea, dyspnea, hypoventilation, pulmonary congestion 

Medical and Surgical procedures: Light anesthesia 

Lymphatic system and Blood disorders: Anemia 

Eye disorders: visual impairment, Photopsia 

General:  hyperpyrexia, pyrexia, Chills, pain, thirst 

Nervous system disorders: dizziness, neuralgia, speech disorder, Convulsion, headache, neuritis 

Urinary or Renal disorders: polyuria, Oliguria 

Subcutaneous tissue and skin disorders: pruritus, urticaria, Hyperhidrosis, rash 

Vascular disorders: hemorrhage, hypotension, Blood pressure fluctuation, hypertension 

Black Box Warning: 

dexmedetomidine does not have a black box warning 

Contraindication/Caution: 

Contraindication: 

  • Hypersensitivity: It should not be used in patients who have known hypersensitivity or allergy to dexmedetomidine or any of its components. 
  • Bradycardia: dexmedetomidine can cause bradycardia (slow heart rate), and therefore, it is contraindicated in patients with known or suspected severe bradycardia. 
  • Heart Block: It should not be used in patients with second-degree or third-degree heart block unless there is a functioning artificial pacemaker in place. 
  • Hypotension: dexmedetomidine can cause a decrease in blood pressure, and hence, it is contraindicated in patients with hypotension or those who are at risk of developing severe hypotension. 
  • Porphyria: dexmedetomidine is contraindicated in patients with a history of porphyria, as it may exacerbate the condition.

Caution: 

  • Hemodynamic Instability: dexmedetomidine can cause changes in heart rate and blood pressure. It should be used with caution in patients with unstable cardiovascular conditions, including severe cardiac disease, recent myocardial infarction, or unstable hemodynamics. 
  • Respiratory Impairment: dexmedetomidine may cause respiratory depression. It should be used with caution in patients with compromised respiratory function or those at risk of respiratory depression, such as patients with chronic obstructive pulmonary disease (COPD) or sleep apnea. 
  • Elderly Patients: These are more sensitive to the effects of dexmedetomidine. Close monitoring is necessary, and dose adjustments may be needed. 
  • Pregnancy and Lactation: The safety of dexmedetomidine during pregnancy and lactation is not well established. It should be used with caution in these populations, and the potential benefits should be weighed against the potential risks.

Comorbidities: 

  • Cardiovascular Disease: Patients with pre-existing cardiovascular conditions, such as severe cardiac disease, recent myocardial infarction, or heart failure, may be at higher risk of experiencing hemodynamic changes or adverse effects from dexmedetomidine. Close monitoring of heart rate, blood pressure, and cardiac function is recommended. 
  • Respiratory Disease: Patients with respiratory conditions, such as COPD, asthma, or sleep apnea, may be more susceptible to respiratory depression or airway complications with dexmedetomidine. Adequate respiratory monitoring and support should be provided during administration. 
  • Hepatic Impairment: dexmedetomidine is metabolized in the liver, so caution is advised in patients with liver dysfunction or impaired hepatic function. Dose adjustments may be necessary in these individuals. 
  • Renal Impairment: dexmedetomidine is primarily eliminated through renal excretion. Patients with renal impairment may experience altered drug clearance, and dosage adjustments may be required based on the degree of renal dysfunction. 

Pregnancy consideration: US FDA pregnancy category: C 

Lactation: Excreted into human milk: Unknown  

Pregnancy category: 

  • Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
  • Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
  • Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
  • Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
  • Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
  • Category N: There is no data available for the drug under this category. 

Pharmacology: 

dexmedetomidine is the highly selective alpha-2 adrenergic agonist with sedative, analgesic, and anxiolytic properties. It acts primarily on the alpha-2 receptors in the brain, resulting in the inhibition of norepinephrine release and subsequent modulation of the central nervous system activity. The pharmacological effects of dexmedetomidine include sedation, anxiolysis, sympatholysis, and analgesia. 

dexmedetomidine also has dose-dependent effects on different receptors. At lower doses, it primarily activates alpha-2 receptors, leading to sedation and anxiolysis. At higher doses, it may also activate alpha-1 adrenergic receptors, resulting in vasoconstriction and increased blood pressure.  

Pharmacodynamics: 

  • Sedation and anxiolysis: dexmedetomidine induces a state of sedation, relaxation, and reduced anxiety. It promotes sleep and can be titrated to achieve the desired level of sedation without causing respiratory depression. 
  • Analgesia: dexmedetomidine has analgesic properties and can help alleviate pain. It acts on the alpha-2 receptors in the spinal cord, reducing the transmission of pain signals. 
  • Sympatholysis: dexmedetomidine causes sympatholysis, leading to a decrease in sympathetic outflow. This results in a reduction in heart rate, blood pressure, and systemic vascular resistance. 
  • Preservation of respiratory function: Unlike many other sedative agents, dexmedetomidine does not cause significant respiratory depression. It maintains the patient’s ability to maintain spontaneous breathing, making it a suitable choice for sedation in patients requiring respiratory support. 
  • Neuroprotective effects: dexmedetomidine has shown neuroprotective properties in various studies, potentially reducing brain injury, and improving neurological outcomes in certain conditions.

Pharmacokinetics: 

Absorption 

dexmedetomidine can be administered intravenously (IV) or intranasally. When given intravenously, it rapidly and completely enters the systemic circulation, allowing for quick onset of action. Intranasal administration provides a less invasive alternative but may have slower absorption. 

Distribution 

dexmedetomidine has a moderate volume of distribution, indicating extensive distribution throughout the body. It readily crosses the blood-brain barrier and reaches therapeutic concentrations in the central nervous system, contributing to its sedative effects. 

Metabolism 

dexmedetomidine undergoes hepatic metabolism primarily through the cytochrome P450 2A6 (CYP2A6) enzyme pathway. The major metabolite formed is 3-hydroxy-dexmedetomidine, which is pharmacologically inactive. The metabolism of Dexmedetomidine is relatively slow compared to its elimination, resulting in a longer duration of action. 

Elimination and excretion 

dexmedetomidine is primarily eliminated through renal excretion. Approximately 95% of the administered dose is excreted in the urine, with only a small fraction being excreted unchanged. The elimination half-life of dexmedetomidine is around 2 to 3 hours in adults. 

Administration: 

dexmedetomidine is primarily administered intravenously (IV) or intranasally. The exact administration method, dose, and duration of treatment will depend on the specific indication and the patient’s individual characteristics. 

For intravenous administration, dexmedetomidine is typically given as a continuous infusion. It is diluted in an appropriate IV solution and administered using an infusion pump. The infusion rate is carefully adjusted to achieve the desired sedation level, which can range from light to deep sedation. 

Intranasal administration of dexmedetomidine involves the use of a nasal spray or drops. The drug is administered into one or both nostrils using a suitable device or applicator. The dosage and frequency of intranasal administration may vary depending on the specific formulation and indication. 

Patient information leaflet 

Generic Name: dexmedetomidine 

Pronounced: (dex-meh-deh-TOE-mi-deen)  

Why do we use dexmedetomidine? 

  • Sedation: dexmedetomidine is commonly used for procedural sedation, such as during surgeries or other invasive procedures. It provides a calming and sedative effect, allowing patients to remain comfortable and cooperative. 
  • Intensive care unit (ICU) sedation: dexmedetomidine is often used for sedation in patients who require mechanical ventilation or other intensive care support. It offers a unique sedative profile with minimal respiratory depression and the ability to maintain natural sleep patterns. 
  • Anesthesia adjunct: dexmedetomidine can be used as an adjunct to general anesthesia to provide sedation and reduce the need for other anesthetic agents. It can help smooth the induction and emergence from anesthesia and provide postoperative analgesia. 
  • Analgesia: dexmedetomidine has analgesic properties and can be used as a multimodal pain management approach. It can reduce the need for opioids and provide effective pain relief in certain surgical procedures or postoperative settings. 
  • Agitation and delirium management: dexmedetomidine is sometimes used to manage agitation or delirium in hospitalized patients, particularly in the ICU or postoperative setting. It can help promote a calm and cooperative state while minimizing the risk of oversedation. 

ADVERTISEMENT 

dexmedetomidine

Brand Name :

Precedex, Igalmi

Synonyms :

dexmedetomidine

Class :

Sedatives




No data available for drug.

Dosage Forms & Strengths 

injectable solution 

Glass vial with a single dosage of 200mcg/2mL (100mcg/mL).  

Further dilution is required before administration 

Sublingual film 

180mg 

120mg 

injectable solution ready-to-use 

0.9% NaCl 1000mcg/250mL (4mcg/mL) 

0.9% NaCl 400mcg/100mL (4mcg/mL) 

0.9% NaCl 200mcg/50mL (4mcg/mL) 

0.9% NaCl 80mcg/20mL (4mcg/mL) 

procedural Sedation 

Loading dose: 1 mcg/kg Intravenous over 10 mins
Maintenance dose: 0.6 mcg/kg/hr Intravenous titrate to effect (generally 0.2 to 1 mcg/kg/hr)
fiberoptic intubation while Awake
Loading dose: 1 mcg/kg Intravenous over 10 mins
Maintenance dose: 0.7 mcg/kg/hr Intravenous till endotracheal tube is secured



schizophrenia 

Mild/moderate
120 mcg Sublingual or buccal initially
If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 240 mcg/day
Severe
180 mcg Sublingual or buccal initially
If the agitation continues, administer 90 mcg in two doses at least 2 hours apart; do not exceed more than 360 mcg/day



Dose Adjustments

Dosage Modifications
Intravenous:
Consider lowering the dosage in individuals with hepatic impairment and those over 65 yrs of age; clearance declines with increasing severity of the hepatic impairment
Renal impairment: Dose adjustment is not required
Sublingual or buccal:
Renal impairment
dose adjustment is not necessary
Hepatic impairment
Mild/moderate (Child-Pugh score A or B)
Mild/moderate agitation: 90 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 210 mcg/day
Severe agitation: 120 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 240 mcg/day
Severe (Child-Pugh score C)
Mild/moderate agitation: 60 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 180 mcg/day
Severe agitation: 90 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 210 mcg/day

Dosage Forms & Strengths 

injectable solution 

Glass vial with a single dosage of 200mcg/2mL (100mcg/mL).  

Further dilution is required before administration 

Sublingual film 

180mg 

120mg 

injectable solution ready-to-use 

0.9% NaCl 1000mcg/250mL (4mcg/mL) 

0.9% NaCl 400mcg/100mL (4mcg/mL) 

0.9% NaCl 200mcg/50mL (4mcg/mL) 

0.9% NaCl 80mcg/20mL (4mcg/mL) 

procedural Sedation 

Less than 1 month: Safety & efficacy were not established
Sedation is initiated during non-invasive procedures
1 month to less than 2 yrs: 1.5 mcg/kg intravenous loading infusion; infuse for 10 minutes
2 yrs to less than 18 yrs: 2 mcg/kg intravenous loading infusion; infuse for 10 minutes
if clinically indicated, Consider lowering dose
Sedation should be maintained throughout non-invasive procedures
1 month to less than 18 yrs: 1.5 mcg/kg/hr intravenous initially; titrate inorder to achieve a desired clinical effect within a dose range of about 0.5 to 1.5 mcg/kg/hr



Dosage Forms & Strengths 

injectable solution 

Glass vial with a single dosage of 200mcg/2mL (100mcg/mL).  

Further dilution is required before administration 

Sublingual film 

180mg 

120mg 

injectable solution ready-to-use 

0.9% NaCl 1000mcg/250mL (4mcg/mL) 

0.9% NaCl 400mcg/100mL (4mcg/mL) 

0.9% NaCl 200mcg/50mL (4mcg/mL) 

0.9% NaCl 80mcg/20mL (4mcg/mL) 

procedural Sedation 

Loading dose: 1 mcg/kg Intravenous over 10 mins
Maintenance dose: 0.6 mcg/kg/hr Intravenous titrate to effect (generally 0.2 to 1 mcg/kg/hr)
fiberoptic intubation while Awake
Loading dose: 1 mcg/kg Intravenous over 10 mins
Maintenance dose: 0.7 mcg/kg/hr Intravenous till endotracheal tube is secured



schizophrenia 

Mild/moderate
120 mcg Sublingual or buccal initially
If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 240 mcg/day



Dose Adjustments

Dosage Modifications
Intravenous:
Consider lowering the dosage in individuals with hepatic impairment and those over 65 yrs of age; clearance declines with increasing severity of the hepatic impairment
Renal impairment: Dose adjustment is not required
Sublingual or buccal:
Renal impairment
dose adjustment is not necessary
Hepatic impairment
Mild/moderate (Child-Pugh score A or B)
Mild/moderate agitation: 90 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 210 mcg/day
Severe agitation: 120 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 240 mcg/day
Severe (Child-Pugh score C)
Mild/moderate agitation: 60 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 180 mcg/day
Severe agitation: 90 mcg Sublingual initially; If the agitation continues, administer 60 mcg in two doses at least 2 hours apart; do not exceed more than 210 mcg/day

DRUG INTERACTION

dexmedetomidine

&

  • beta carotene/vitamin C/minerals
  • aloe vera gel/urea
  • aloe vera gel/glycerine
  • alpha-lipoic acid/benfotiamine/chromium/folic acid/mecobalamin / vit b6
  • alprazolam/propranolol
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  • ibuprofen/dextropropoxyphene
  • ambroxol/cetirizine/phenylephrine/ guaiphenesin/menthol
  • dextropropoxyphene/dexchlorpheniramine maleate/bromhexine
  • promegestone
  • batroxobin
  • bencyclane
  • benfluorex
  • acetylpheneturide
  • abarelix
  • abetimus
  • naftidrofuryl
  • nalorphine
  • oxiracetam
  • letosteine
  • lafutidine
  • leuprorelin
  • levodropropizine
  • glutaral
  • losartan/ramipril
  • gallopamil
  • lanatoside c
  • lauromacrogol
  • gestodene
  • aceclofenac/methyl salicylate/menthol/linseed oil/capsaicin
  • aceclofenac/paracetamol/tizanidine
  • alginic acid/magaldrate/simethicone
  • aceclofenac/paracetamol
  • aceclofenac/rabeprazole
  • alginic acid
  • pantoprazole and domperidone
  • urokinase
  • rimiterol
  • olanzapine/fluoxetine
  • normethadone/hydroxyephedrine
  • myrtol
  • moxonidine
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  • sodium hypochlorite solution
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  • oxedrine
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  • orgotein (investigational)
  • oxaceprol
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  • lauric acid
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  • abiraterone acetate and niraparib
  • ichthammol
  • levamisole
  • naftazone
  • nefopam
  • oxprenolol
  • oxybuprocaine
  • elranatamab-bcmm
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  • isoaminile
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  • meradimate
  • molsidomine
  • monobenzone
  • mequinol/gluconolactone/ lactobionic acid/ arbutin
  • medifoxamine
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  • metergoline
  • methantheline
  • methdilazine
  • metocurine
  • micronomicin
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  • mephenesin
  • menadione
  • medrysone
  • metixene
  • levobetaxolol
  • guaiacol glycerol ether
  • eucalyptol
  • sodium tetradecyl sulfate
  • sugammadex
  • carbetocin
  • certoparin
  • chlorcyclizine/pseudoephedrine
  • cephapirin
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  • msud analog
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  • ethchlorvynol
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  • soapwort
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  • technetium Tc-99m tetrofosmin
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  • amylmetacresol/dextromethorphan hydrobromide
  • anileridine phosphate
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  • standard hyperkalemic cardioplegia solution
  • technetium tc-99m mertiatide
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  • bemotrizinol / bisoctrizole
  • benfotiamine
  • bemotrizinol + titanium dioxide + zinc oxide
  • technetium Tc-99m oxidronate
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  • benziodarone
  • octinoxate/bisoctrizole
  • bicisate dihydrochloride
  • technetium Tc-99m bicisate
  • norelgestromin/ethinyl estradiol
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  • ximelagatran (investigational)
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  • mumps virus vaccine, live
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  • framycetin, phenylephrine, and gramicidin
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  • blue-green algae
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  • follitropin beta
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  • hydroxypropyl methylcellulose
  • icodextrin
  • lipid emulsion (soybean, medium-chain triglyceride, olive, and fish oils; [SMOF])
  • iodinated I 125 albumin
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  • fusidic acid and betamethasone
  • gallium citrate Ga-67
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  • gadofosveset
  • follitropin delta
  • follitropin alfa and lutropin alfa
  • follitropin alfa
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  • clofedanol
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  • glucosamine sulfate, chondroitin sulfate and Msm
  • squill
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  • bitter melon
  • apraclonidine
  • chlophedianol/dexbrompheniramine/pseudoephedrine
  • wild jujube
  • chitosan
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  • dexbrompheniramine and phenylephrine
  • diethylene triamine penta-acetic acid
  • dexchlorpheniramine and pseudoephedrine
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  • chlophedianol and dexbrompheniramine
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  • 14-C urea breath test
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  • landiolol (Pending FDA approval)
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  • mineral oil otic
  • zolmitriptan transdermal
  • midazolam intranasal
  • fosinopril/hydrochlorothiazide
  • caplacizumab
  • arginine
  • sodium phenylbutyrate
  • meloxicam/rizatriptan
  • manganese
  • acetaminophen/pamabrom/pyridoxine
  • varicella zoster immune globulin, human
  • amitriptyline/perphenazine
  • narsoplimab (Pending FDA Approval)
  • amlodipine/perindopril
  • imiglucerase
  • canagliflozin/metformin
  • tafamidis meglumine
  • somatrogon-ghla
  • glimepiride/rosiglitazone
  • becaplermin
  • lithium
  • loxapine inhaled
  • nicotine transdermal
  • tixagevimab and cilgavimab (Investigational)
  • muromonab CD3
  • ansuvimab
  • coal tar bath products
  • fibrin sealant
  • arimoclomol (FDA Approval Pending)
  • varenicline intranasal
  • aducanumab
  • oxycodone/naloxone
  • ritlecitinib
  • sodium polystyrene sulfonate
  • calcipotriene/betamethasone
  • calcium hydroxylapatite
  • cantharidin topical
  • doxepin cream
  • clocortolone
  • formaldehyde topical
  • sodium sulfide topical
  • collagenase
  • selegiline transdermal
  • foscarbidopa/foslevodopa (FDA approval pending)
  • saxagliptin/metformin
  • linagliptin/metformin
  • linzagolix (FDA approval pending)
  • efgartigimod/hyaluronidase SC
  • elamipretide (Pending FDA approval)
  • rozanolixizumab
  • diazoxide
  • glimepiride/pioglitazone
  • cipaglucosidase alfa
  • dihydroergotamine intranasal
  • delandistrogene moxeparvovec
  • beremagene geperpavec
  • hyaluronic acid and derivatives
  • hyaluronic acid, non-animal stabilized
  • eplontersen (FDA Approval Pending)
  • nitric oxide gas
  • sodium phenylbutyrate and taurursodiol
  • treprostinil SC
  • viltolarsen
  • albuterol/ipratropium
  • budesonide inhaled
  • budesonide rectal
  • palovarotene (FDA Approval Pending)
  • sodium sulfate/potassium chloride/magnesium sulfate/polyethylene glycol
  • amino acids mixture
  • aminobenzoate potassium
  • elivaldogene autotemcel
  • naproxen and sumatriptan
  • sumatriptan intranasal
  • alglucerase
  • metformin/rosiglitazone
  • ertugliflozin/metformin
  • elosulfase alfa
  • calcium carbonate/magnesium hydroxide
  • starch suppository
  • abicipar pegol (FDA Approval Pending)
  • riboflavin 5′-phosphate ophthalmic
  • povidone ophthalmic
  • glycerin oropharyngeal
  • dimethicone topical
  • menthol topical, dimethicone topical
  • pramoxine topical, menthol topical and dimethicone topical
  • phosphorated carbohydrate
  • brilliant blue G ophthalmic
  • brolucizumab intravitreal
  • purified water, ophthalmic
  • hydroxyethyl cellulose ophthalmic
  • ranibizumab intravitreal implant
  • sodium chloride hypertonic, ophthalmic 
  • cetirizine ophthalmic
  • phentolamine ophthalmic
  • ganciclovir ophthalmic
  • triamcinolone intravitreal
  • ocriplasmin intravitreal
  • atoltivimab/maftivimab/odesivimab
  • pegcetacoplan intravitreal
  • triamcinolone acetonide extended-release injectable suspension
  • tobramycin/loteprednol ophthalmic
  • 2-octyl cyanoacrylate
  • vitamins A & D topical
  • diphenhydramine/allantoin topical
  • pyrethrins/piperonyl butoxide
  • lodoxamide ophthalmic
  • obeticholic acid
  • fluocinolone intravitreal implant
  • sincalide
  • linaclotide
  • nedocromil ophthalmic
  • cysteamine ophthalmic
  • avacincaptad pegol intravitreal
  • azelastine ophthalmic
  • bacitracin ophthalmic
  • propylene glycol ophthalmic
  • rimexolone ophthalmic
  • metoclopramide intranasal
  • mirikizumab (FDA approval pending)
  • netarsudil ophthalmic
  • cenegermin
  • dexamethasone ophthalmic insert
  • prednisolone ophthalmic
  • phenylephrine and cocoa butter rectal
  • phenylephrine and witch hazel topical
  • phenylephrine, pramoxine, glycerin and petrolatum rectal
  • bisacodyl rectal
  • aluminum hydroxide/magnesium carbonate
  • aluminum hydroxide/magnesium hydroxide
  • hyoscyamine spray
  • methenamine/methylene blue/ hyoscyamine/ sodium phosphate monobasic/ phenyl salicylate
  • phenylephrine
  • chlorophyll
  • castor oil
  • cholic acid
  • phenol oropharyngeal
  • articaine/epinephrine
  • antithymocyte globulin equine
  • aluminum hydroxide/magnesium trisilicate
  • methenamine/hyoscyamine
  • hydrocortisone topical/pramoxine topical 
  • sodium fluoride topical
  • mesna
  • C1 esterase inhibitor recombinant
  • menthol and pectin
  • menthol oropharyngeal
  • pectin oropharyngeal
  • gepirone
  • Goldenseal
  • polyethylene glycol and electrolytes
  • polyethylene glycol/electrolytes/sodium ascorbate/ascorbic acid
  • brompheniramine/pseudoephedrine/dextromethorphan
  • brompheniramine phenylephrine
  • acetaminophen/doxylamine/phenylephrine
  • doxylamine/acetaminophen/pseudoephedrine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan
  • acetaminophen/doxylamine/dextromethorphan/phenylephrine
  • eslicarbazepine
  • fluticasone and salmeterol
  • codeine, acetaminophen, butalbital and caffeine
  • codeine, chlorpheniramine and phenylephrine
  • iodine
  • povidone iodine
  • butalbital/aspirin/caffeine/codeine
  • polyethylene glycol 400/propylene glycol ophthalmic 
  • pegvaliase
  • amivantamab
  • iopamidol
  • codeine and pseudoephedrine
  • emtricitabine, rilpivirine, tenofovir DF
  • penicillin G aqueous
  • miconazole topical
  • miconazole vaginal
  • ciprofloxacin inhaled (Pending FDA approval)
  • ceftazidime/avibactam
  • ceftolozane/​tazobactam
  • aztreonam inhalation
  • amphotericin B cholesteryl sulfate
  • miconazole oral
  • elvitegravir/cobicistat/emtricitabine/tenofovir DF
  • isavuconazonium sulfate
  • dapivirine intravaginal (FDA Approval Pending)
  • lamivudine/raltegravir
  • codeine/triprolidine/pseudoephedrine
  • cadexomer iodine
  • brompheniramine/pseudoephedrine
  • codeine/acetaminophen
  • codeine/guaifenesin
  • beclomethasone inhaled
  • epoetin beta/methoxy polyethylene glycol
  • voreloxin(Orphan Drug)
  • rociletinib
  • pitcher plant
  • phosphatidylserine
  • telotristat ethyl
  • copper CU 64 dotatate
  • urea topical
  • exenatide subdermal implant
  • asenapine transdermal
  • ethiodized oil
  • urea oral
  • miglustat
  • acalisib(Investigational)
  • acetophenazine
  • guggul
  • aceneuramic acid
  • mestranol/norethindrone
  • reishi
  • lactitol
  • vonoprazan fumarate
  • motherwort
  • silver nitrate
  • salicylic acid/sulfur shampoo
  • salicylic acid topical
  • ketorolac ophthalmic
  • ketoconazole topical
  • Japanese encephalitis virus vaccine
  • dibucaine topical ointment
  • ketorolac intranasal
  • ketorolac/phenylephrine ophthalmic
  • rotavirus oral vaccine, live
  • guarana
  • hops
  • krill oil
  • salicylic acid/coal tar shampoo
  • sufentanil SL
  • pancrelipase
  • passion flower
  • pepdite one plus
  • nivolumab and relatlimab
  • relatlimab (Pending FDA Approval)
  • benzalkonium chloride/benzocaine
  • ketotifen, drug-eluting contact lens
  • calcitriol topical
  • oxymetazoline topical
  • alclometasone topical
  • capsaicin topical
  • diclofenac/misoprostol
  • diclofenac ophthalmic
  • diclofenac topical
  • pramoxine/calamine topical
  • veverimer
  • tolazoline
  • olopatadine ophthalmic
  • lutetium lu 177-dota-tate
  • lutetium lu 177 vipivotide tetraxetan
  • strontium 89 chloride
  • interferon alfa n3
  • lutetium Lu 177- Diethylenetriamine Pentaacetic acid-omburtamab (FDA Approval Pending)
  • samarium sm 153 lexidronam
  • cytomegalovirus immune globulin (CMV IG)
  • antithymocyte globulin rabbit
  • inolimomab (Pending FDA Approval)
  • olopatadine intranasal
  • olopatadine intranasal/​mometasone, intranasal
  • benzocaine/butamben/tetracaine topical
  • antipyrine/benzocaine/phenylephrine
  • dyclonine/menthol
  • surufatinib
  • fruquintinib
  • tepotinib 
  • dostarlimab
  • hepatitis B immune globulin (HBIG)
  • remestemcel-L
  • benzocaine/menthol oropharyngeal
  • interferon beta 1b
  • tetracaine/oxymetazoline intranasal
  • benzocaine oropharyngeal
  • benzalkonium chloride/menthol/petrolatum topical
  • inamrinone
  • alpha 1 proteinase inhibitor
  • potassium bicarbonate/potassium citrate
  • potassium phosphate/sodium acid phosphate
  • asparaginase Erwinia chrysanthemi recombinant
  • motixafortide
  • pegloticase
  • etesevimab
  • Rho(D) immune globulin
  • tetanus immune globulin (TIG)
  • reltecimod (pending FDA approval)
  • avasopasem
  • trimethoprim/polymyxin B ophthalmic
  • naphazoline ophthalmic
  • sulfacetamide topical
  • sirolimus intravitreal (pending FDA approval)
  • sirolimus protein bound
  • sirolimus topical
  • glycopyrronium tosylate topical
  • sofpironium
  • olmesartan, amlodipine and hydrochlorothiazide
  • dovitinib (Pending FDA Approval)
  • epinephrine inhaled
  • quizartinib (Pending FDA Approval)
  • ranibizumab intravitreal injection
  • sodium hyaluronate
  • bacitracin and lidocaine topical
  • brimonidine topical
  • benzoyl peroxide and tretinoin topical
  • talquetamab
  • betrixaban
  • acetaminophen/caffeine/pyrilamine
  • fentanyl transmucosal
  • bacitracin topical
  • buprenorphine,long-acting injection
  • buprenorphine buccal
  • nalmefene intranasal
  • sulbactam/durlobactam
  • metronidazole topical 
  • daratumumab/hyaluronidase
  • glofitamab
  • rituximab-hyaluronidase
  • drospirenone/ethinyl estradiol/levomefolate
  • loncastuximab tesirine
  • ingenol mebutate topical
  • momelotinib
  • trastuzumab/deruxtecan
  • trastuzumab/hyaluronidase
  • trastuzumab duocarmazine
  • lifileucel
  • umbralisib
  • eflornithine/sulindac
  • cytarabine/daunorubicin liposomal
  • doxorubicin liposomal
  • epcoritamab
  • lanadelumab  
  • esomeprazole/naproxen 
  • terbinafine topical
  • ravulizumab
  • clotrimazole topical
  • choline magnesium trisalicylate
  • tacrolimus ointment
  • mechlorethamine topical
  • donislecel
  • pozelimab (Pending FDA Approval)
  • human rabies immune globulin (HRIG)
  • melphalan flufenamide
  • sintilimab (Pending FDA Approval)
  • oportuzumab monatox (Pending FDA Approval)
  • sotorasib
  • irinotecan liposomal
  • sulfur topical
  • silver sulfadiazine
  • capsaicin transdermal
  • sutimlimab
  • tretinoin topical
  • acetaminophen rectal
  • menthol topical
  • naftifine
  • oatmeal, colloidal topical
  • oxiconazole
  • methylsalicylate/menthol topical
  • C1 inhibitor human
  • lifitegrast ophthalmic
  • prednisolone/sulfacetamide ophthalmic
  • mannitol inhalation
  • ofloxacin otic
  • petrolatum & mineral oil topical
  • clascoterone topical
  • gefapixant (Pending FDA Approval)
  • colesevelam
  • technetium Tc 99m succimer
  • nebivolol/valsartan
  • ciprofloxacin/fluocinolone acetonide, otic
  • finafloxacin otic
  • magnesium hydroxide/mineral oil
  • phenylephrine/mineral oil/petrolatum rectal
  • carbamide peroxide oral
  • atropine ophthalmic
  • sodium sulfacetamide/sulfur
  • sulfacetamide ophthalmic
  • lucinactant
  • benzonatate
  • besifloxacin ophthalmic
  • benzhydrocodone/acetaminophen
  • beractant
  • trimagnesium citrate anhydrous
  • vitamin b2
  • carbamide peroxide otic
  • mineral oil topical
  • ethyl alcohol intranasal
  • boric acid/alcohol otic
  • absorbable gelatin compressed sponge, USP
  • absorbable gelatin sponge, USP
  • vincristine liposomal
  • technetium Tc 99m albumin aggregated injection
  • metaproterenol
  • budesonide inhaled/formoterol/glycopyrrolate inhaled
  • epinephrine racemic
  • umeclidinium bromide/vilanterol inhaled
  • indacaterol, inhaled/glycopyrrolate inhaled
  • betaine  
  • laronidase 
  • estrogens esterified/methyltestosterone            
  • cerliponase alfa
  • ertugliflozin/sitagliptin
  • hawthorn
  • shepherd’s purse
  • thiamine
  • naphazoline/glycerin ophthalmic
  • oxymetazoline ophthalmic
  • dorzolamide
  • dexamethasone intraocular
  • dexamethasone/ciprofloxacin
  • dexamethasone ophthalmic
  • metipranolol ophthalmic
  • timolol ophthalmic
  • boron
  • fezolinetant
  • pegunigalsidase alfa-iwxj
  • biotin
  • pantothenic acid
  • silicon
  • sodium acid phosphate
  • hypochlorous acid topical
  • methenamine/sodium acid phosphate
  • aviptadil 
  • bremelanotide
  • glucagon intranasal
  • metformin and repaglinide
  • bai ji
  • pau d’arco
  • juzentaihoto
  • mistletoe
  • quercetin
  • rosemary
  • sheng di huang
  • chasteberry
  • maitake
  • grapefruit
  • lentinan
  • juniper
  • nettle
  • parsley
  • rose hips
  • tongkat ali
  • horny goat weed
  • damiana
  • yohimbe
  • insulin NPH
  • aprocitentan
  • noni Juice
  • sodium iodide I-131
  • green tea
  • sea cucumber
  • wheat germ extract
  • fenofibrate micronized 
  • rogisen
  • danshen
  • lutein
  • witch hazel
  • dextroamphetamine transdermal
  • amphetamine/dextroamphetamine
  • hoodia
  • kolanut
  • boswellia
  • opuntia ficus indica
  • lavender
  • nadh
  • tea tree oil
  • metformin/sitagliptin 
  • dapagliflozin/ metformin/saxagliptin  
  • antihemophilic factor recombinant
  • inclisiran
  • bempedoic acid/ezetimibe
  • volanesorsen  
  • omega 3 carboxylic acids
  • pericyazine
  • levomepromazine (methotrimeprazine)
  • betaxolol ophthalmic
  • respiratory syncytial virus vaccine, adjuvanted
  • phenylephrine hydrochloride and tropicamide ophthalmic
  • alirocumab
  • neomycin/polymyxin B/gramicidin ophthalmic
  • factor IX
  • gentamicin topical
  • ansofaxine (Pending FDA Approval)
  • zuranolone
  • factor IX, recombinant
  • factor IX complex
  • factor XIII A-subunit, recombinant
  • factor X, human
  • mesalamine rectal
  • etrasimod
  • anti-inhibitor coagulant complex
  • factor IX, recombinant/albumin fusion protein
  • fibrinogen, human
  • aminocaproic acid
  • metyrosine
  • nonoxynol-9 vaginal
  • progesterone intravaginal gel
  • ipecac syrup
  • botulinum antitoxin, heptavalent
  • pentetate calcium trisodium
  • crotalidae polyvalent immune FAB (ovine)
  • dehydrated alcohol injection 
  • gold sodium thiomalate (Discontinued)
  • lactic acid/citric acid/potassium bitartrate vaginal
  • von Willebrand factor, recombinant
  • luspatercept
  • digoxin immune FAB (Antidote)
  • crotalidae immune FAB (equine)
  • magnesium (Antidote)
  • pyridoxine (Antidote)
  • edetate calcium disodium
  • albumin IV
  • nitroglycerin sublingual
  • obiltoxaximab
  • anthrax immune globulin
  • nitroglycerin topical
  • dextrose
  • nesiritide
  • estradiol vaginal
  • bazedoxifene/conjugated estrogens
  • botulism immune globulin iv
  • amoxicillin/omeprazole/rifabutin
  • synthetic human angiotensin II
  • nitroglycerin IV
  • nitroglycerin translingual
  • nitroprusside sodium
  • tetrahydrozoline/zinc sulfate/hypromellose ophthalmic
  • sodium citrate/citric acid
  • pemetrexate
  • methicillin
  • plasminogen 
  • acai
  • american ginseng
  • cordyceps
  • tramadol/acetaminophen
  • belladonna alkaloids/phenobarbital
  • erythromycin topical/benzoyl peroxide
  • glucosamine sulfate
  • panax ginseng (suppl/herb)
  • tolnaftate
  • sulopenem etzadroxil/probenecid
  • sulfur hexafluoride
  • sotrovimab
  • arbaclofen
  • rifampin/isoniazid
  • clindamycin /tretinoin topical
  • benzoyl peroxide/clindamycin topical
  • apremilast
  • antivenins, centuroides (scorpion)
  • bamlanivimab and etesevimab
  • vilobelimab
  • gadobenate
  • pentosan polysulfate sodium
  • methylsalicylate/menthol/camphor topical
  • antivenin, black widow spider
  • benzoyl peroxide and hydrocortisone
  • clindamycin topical
  • isometheptene, dichloralphenazone and acetaminophen
  • acetaminophen and phenyltoloxamine
  • erythromycin topical
  • erythromycin ophthalmic
  • alpha hydroxy acids, topical
  • buprenorphine transdermal
  • butalbital/acetaminophen/caffeine
  • buprenorphine/samidorphan
  • buprenorphine subdermal implant
  • celecoxib/tramadol
  • drospirenone/ethinyl estradiol
  • resorcinol/sulfur
  • eflornithine
  • rifampin/isoniazid/pyrazinamide
  • tofersen
  • devil’s claw
  • ticarcillin/clavulanate
  • atropine/pralidoxime
  • aprepitant
  • suramin
  • phenelzine 
  • artichoke
  • american dogwood
  • attapulgite
  • atlantic cedar
  • axalimogene filolisbac
  • sodium thiosulfate & sodium nitrite
  • ataluren
  • omidubicel-onlv
  • capsicum
  • ginger
  • cryoprecipitate
  • bictegravir/emtricitabine/tenofovir DF
  • emtricitabine/tenofovir DF
  • fo-ti
  • siberian ginseng
  • granulocytes
  • zinc substituted heme C
  • zinc trihydroxide
  • ashwagandha 
  • cat’s claw
  • glandular products
  • SAMe
  • shark cartilage
  • altovis
  • feverfew
  • horse chestnut
  • magnesium aspartate
  • octacosanol
  • pleurisy root
  • star anise
  • butterbur
  • elderberry
  • licorice (Suppl/herb)
  • aconite
  • pentetate zinc trisodium
  • menthol topical/zinc oxide topical
  • corn-starch/kaolin/zinc oxide topical
  • 5-htp
  • butcher’s broom
  • articulin
  • bearberry
  • goldenrod
  • progesterone, natural
  • black cohosh
  • wild yam
  • cranberry
  • dong quai
  • phytoestrogens
  • norethindrone
  • false Unicorn Root
  • raspberry Leaf
  • asafoetida
  • turmeric
  • dehydroepiandrosterone (DHEA)
  • hyaluronan
  • aliskiren/amlodipine
  • octreotide (Antidote)
  • tranexamic acid injection
  • duocal
  • neocate infant formula
  • pediatric Eo28
  • aloe
  • red clover
  • propolis
  • androstenedione
  • heartsease
  • comfrey
  • bilberry
  • chamomile
  • eyebright
  • calendula
  • sage
  • yucca
  • polypody
  • odevixibat
  • vinpocetine
  • olanzapine/samidorphan
  • creatine
  • yerba mate
  • spesolimab
  • azficel-T
  • tiludronate
  • estetrol and drospirenone
  • pseudoephedrine/fexofenadine
  • lincomycin
  • neomycin oral
  • fluocinolone acetonide, otic
  • tretinoin/ hydroquinone/ fluocinolone
  • halobetasol topical
  • hydrocortisone/​iodoquinol
  • penicillin G procaine /penicillin G benzathine
  • hydrocortisone probutate topical
  • colistin/neomycin/hydrocortisone/thonzonium otic
  • ebola zaire vaccine
  • hepatitis a/​b vaccine
  • vibegron
  • lindane
  • nystatin topical
  • respiratory syncytial virus (RSV) vaccine
  • chikungunya vaccine
  • tenecteplase
  • reteplase
  • anthrax vaccine adsorbed, adjuvanted
  • meningococcal ABCWY pentavalent vaccine
  • eculizumab
  • cholestyramine
  • tinzaparin
  • taurolidine/​citrate/​heparin
  • protein C concentrate
  • antithrombin alfa
  • antithrombin III
  • multivitamins, vision
  • ibuprofen/​chlorpheniramine/​pseudoephedrine
  • acetaminophen/ibuprofen
  • ibuprofen/pseudoephedrine
  • paclitaxel protein-bound
  • acetic acid vaginal
  • acetic acid otic
  • hydrocodone/ ibuprofen
  • methyl salicylate / isopropanol/ citronellyl acetate/ citric acid
  • ibuprofen and phenylephrine
  • acetylcysteine (Antidote)
  • iron/​folic acid/​vitamin/​mineral
  • iobenguane I-131
  • dolutegravir/rilpivirine
  • chlorhexidine topical
  • chlorhexidine oral
  • thyroid desiccated
  • proparacaine ophthalmic
  • podophyllum resin
  • phendimetrazine
  • phenoxybenzamine
  • polidocanol
  • phentermine and topiramate
  • piflufolastat F18
  • piperacillin/tazobactam
  • prednisolone and gentamicin ophthalmic
  • promethazine and codeine
  • poractant alfa
  • protamine sulfate
  • aflibercept intravitreal
  • prednicarbate
  • promethazine/dextromethorphan
  • codeine, phenylephrine, and promethazine
  • potassium phosphate
  • glatiramer acetate
  • gentamicin (Ophthalmic)
  • leniolisib
  • rezafungin
  • fluorometholone
  • dalfampridine
  • hydrocortisone topical 
  • empagliflozin and linagliptin
  • triamcinolone topical
  • minocycline topical
  • minocycline dental
  • ketotifen ophthalmic
  • darunavir and cobicistat
  • lidocaine topical
  • neomycin/polymyxin B/bacitracin/lidocaine (OTC)
  • lidocaine/ hydrocortisone
  • lidocaine anesthetic
  • lidocaine ophthalmic
  • lidocaine/tetracaine
  • desonide
  • dabigatran
  • fexofenadine
  • fluoride
  • decitabine and cedazuridine
  • dasiglucagon
  • hydroxypropyl cellulose ophthalmic
  • epoetin alfa
  • ibritumomab tiuxetan
  • trimethobenzamide
  • dexamethasone/ tobramycin
  • tafasitamab
  • valacyclovir
  • mebendazole
  • levoleucovorin
  • flaxseed
  • germanium
  • glutathione
  • lycopene
  • pygeum
  • horseradish
  • ziv-aflibercept
  • micafungin
  • trofinetide
  • taliglucerase alfa
  • tildrakizumab
  • sulopenem (Pending FDA Approval)
  • thyrotropin alfa
  • birch
  • thrombin, topical
  • tivozanib
  • tafluprost
  • methohexital
  • urea and hydrocortisone
  • unoprostone ophthalmic
  • trihexyphenidyl
  • ezetimibe
  • evolocumab
  • trifluridine and tipiracil
  • methenamine
  • misoprostol
  • miltefosine
  • rimantadine
  • maralixibat
  • coenzyme Q10
  • chlorella
  • garlic
  • forskolin
  • zavegepant
  • menotropins
  • margetuximab
  • meprobamate
  • melarsoprol
  • evening primrose oil
  • lemongrass
  • molindone
  • fenugreek
  • phytosterols
  • red yeast rice
  • uridine triacetate
  • tropicamide
  • incobotulinumtoxinA
  • Grape Seed Extract
  • carbachol ophthalmic
  • cosyntropin
  • cyclopentolate and phenylephrine
  • carteolol ophthalmic
  • pentazocine/naloxone
  • pentazocine/acetaminophen
  • casimersen
  • carisoprodol, aspirin, and codeine
  • carisoprodol
  • carboprost tromethamine
  • flurandrenolide
  • brinzolamide/brimonidine
  • betamethasone topical
  • omaveloxolone
  • bardoxolone
  • allogeneic processed thymus tissue
  • fluocinolone topical
  • tacrolimus topical
  • ruxolitinib topical
  • pimecrolimus topical
  • sofosbuvir, velpatasvir and voxilaprevir
  • sofosbuvir/velpatasvir
  • mitotane
  • elbasvir/​grazoprevir
  • wheat dextrin
  • vanadium
  • iron/folic acid/vitamin/mineral
  • molybdenum
  • sparsentan
  • velmanase alfa-tycv
  • pegcetacoplan
  • ferrous sulfate
  • cyclosporine ophthalmic
  • ferric pyrophosphate
  • ammonium lactate
  • etelcalcetide
  • iodoquinol
  • sucroferric oxyhydroxide
  • doxercalciferol
  • terconazole vaginal
  • cortisone
  • pyronaridine
  • tetrahydrozoline, ophthalmic
  • tenapanor
  • tesamorelin
  • benazepril/hydrochlorothiazide
  • nadolol and bendroflumethiazide
  • spironolactone and hydrochlorothiazide
  • COVID-19 Vaccine, mRNA
  • atosiban
  • bisoprolol and hydrochlorothiazide
  • ephedrine/guaifenesin
  • clonidine/chlorthalidone
  • captopril/hydrochlorothiazide
  • amlodipine/valsartan/hydrochlorothiazide
  • hydrochlorothiazide and irbesartan
  • candesartan/hydrochlorothiazide
  • ciclesonide intranasal
  • cromolyn sodium ophthalmic
  • methyldopa/hydrochlorothiazide
  • valsartan/hydrochlorothiazide
  • hydrochlorothiazide and triamterene
  • moexipril/hydrochlorothiazide
  • mometasone/intranasal
  • ofloxacin ophthalmic
  • cysteamine
  • metoprolol/hydrochlorothiazide
  • amlodipine/olmesartan
  • eprosartan/hydrochlorothiazide
  • amlodipine/telmisartan
  • hydrochlorothiazide/aliskiren
  • betamethasone/clotrimazole
  • telmisartan/hydrochlorothiazide
  • benazepril/amlodipine
  • bezlotoxumab
  • propranolol/hydrochlorothiazide
  • bupropion/naltrexone
  • burosumab
  • acetylcholine chloride intraocular solution
  • bupivacaine and meloxicam
  • budesonide and formoterol (inhalation)
  • valerian
  • entacapone/levodopa/carbidopa
  • carbidopa/levodopa
  • calaspargase pegol
  • cabotegravir
  • cefixime
  • calfactant
  • brinzolamide
  • daprodustat
  • brimonidine and timolol
  • brodalumab
  • buprenorphine and naloxone
  • hydrocortisone acetic acid otic
  • butorphanol
  • butoconazole
  • adapalene and benzoyl peroxide
  • acrivastine and pseudoephedrine
  • neomycin/polymyxin B/bacitracin topical
  • midodrine
  • baloxavir marboxil
  • bacitracin, neomycin, polymyxin B, and hydrocortisone topical
  • avatrombopag
  • glucagon
  • atenolol/chlorthalidone
  • adefovir
  • activated charcoal
  • avalglucosidase alfa
  • aclidinium and formoterol
  • iclaprim (Pending FDA Approval)
  • ampicillin/sulbactam
  • quinupristin/dalfopristin
  • lamivudine/zidovudine/abacavir
  • acetaminophen and caffeine
  • acetaminophen/pamabrom
  • abacavir and lamivudine
  • anifrolumab
  • elacestrant
  • anidulafungin
  • acetohydroxamic acid
  • alogliptin/pioglitazone
  • anthralin
  • pirtobrutinib
  • gabapentin
  • galsulfase
  • gadoterate meglumine
  • ferric gluconate
  • ferric derisomaltose
  • ethanolamine oleate
  • eteplirsen
  • vasopressin
  • desmopressin
  • meropenem/vaborbactam
  • ecallantide
  • econazole topical
  • dornase alfa
  • aspirin/dipyridamole
  • dipyridamole
  • difenoxin and atropine
  • diflorasone
  • difluprednate ophthalmic
  • eptinezumab
  • diethylpropion
  • dexchlorpheniramine
  • dexmethylphenidate
  • serdexmethylphenidate/​dexmethylphenidate
  • bexagliflozin
  • galcanezumab
  • fremanezumab
  • tapinarof topical
  • darifenacin
  • dalbavancin
  • darbepoetin alfa
  • azilsartan
  • colestipol
  • corticorelin
  • crotamiton
  • crofelemer
  • allogeneic cultured keratinocytes/fibroblasts in bovine collagen
  • tapentadol
  • cyclopentolate
  • polymyxin B/bacitracin topical
  • tavaborole
  • tagraxofusp
  • crisaborole
  • crizanlizumab
  • satralizumab
  • spinosad
  • sacubitril/valsartan
  • sargramostim
  • sebelipase alfa
  • regadenoson
  • ribociclib/letrozole
  • ragweed allergen extract
  • radium-223 dichloride
  • secnidazole
  • setmelanotide
  • polycarbophil
  • plecanatide
  • sacituzumab govitecan
  • pertuzumab
  • pertuzumab/trastuzumab/hyaluronidase
  • pamidronate
  • halcinonide
  • glecaprevir/​pibrentasvir
  • glucarpidase
  • golodirsen
  • dextrose (antidote)
  • hexaminolevulinate
  • iohexol
  • ferric citrate
  • elapegademase
  • emicizumab
  • erenumab
  • danaparoid
  • dantrolene
  • eflapegrastim
  • edaravone
  • amcinonide
  • carglumic acid
  • alcaftadine ophthalmic
  • agalsidase beta
  • afamelanotide
  • fosdenopterin
  • lidocaine and chlorhexidine
  • levorphanol
  • calcifediol
  • factor VIIa, recombinant
  • triheptanoin
  • peanut oral allergen powder
  • teprotumumab
  • poly-L-lactic acid/carboxymethylcellulose/mannitol
  • xenon Xe 129 hyperpolarized
  • ublituximab
  • anacaulase
  • glatiramer
  • peginterferon beta-1a
  • interferon beta-1a
  • onabotulinumtoxinA
  • cycloserine
  • ethionamide
  • cabotegravir and rilpivirine
  • vericiguat
  • omidenepag isopropyl
  • azelastine/fluticasone intranasal
  • benzyl peroxide
  • vutrisiran
  • brimonidine
  • testosterone topical
  • lenacapavir
  • tebentafusp
  • mosunetuzumab
  • faricimab
  • ganirelix
  • nadofaragene firadenovec
  • ozenoxacin
  • guaifenesin
  • adagrasib
  • guselkumab
  • adalimumab-aacf
  • nonoxynol-9
  • nifurtimox
  • nusinersen
  • nitazoxanide
  • mavacamten
  • calcipotriene
  • bimatoprost
  • obinutuzumab
  • amifostine
  • oxycodone/​aspirin
  • oxycodone/ibuprofen
  • oteseconazole
  • oxychlorosene
  • porfimer
  • pramoxine /hydrocortisone topical
  • podofilox
  • quinapril/hydrochlorothiazide
  • acetaminophen/pamabrom/pyrilamine
  • levobunolol
  • paregoric
  • idursulfase
  • lesinurad and allopurinol
  • latanoprost/​netarsudil ophthalmic
  • lactase enzyme
  • bioadherent oral
  • latanoprost and timolol
  • latanoprostene bunod
  • ledipasvir/sofosbuvir
  • imipenem/cilastatin/relebactam
  • imipenem/cilastatin
  • hemin
  • deucravacitinib
  • house dust mite allergen extract
  • halobetasol topical/tazarotene
  • remimazolam
  • somatropin
  • remifentanil
  • ethotoin
  • etidronate
  • empagliflozin, linagliptin, and metformin
  • elvitegravir/cobicistat/emtricitabine/tenofovir AF
  • empagliflozin/metformin
  • evinacumab
  • finasteride and tadalafil
  • flortaucipir (18F)
  • proparacaine/ fluorescein ophthalmic
  • fluorescein/benoxinate ophthalmic
  • fluphenazine
  • alogliptin/​metformin
  • alogliptin/pioglitazone
  • alitretinoin topical
  • dextrose/ sodium citrate/fructose
  • dasabuvir
  • ombitasvir​/paritaprevir/​ritonavir
  • hydrocodone/​chlorpheniramine/​pseudoephedrine
  • hydroxyamphetamine/​tropicamide
  • acamprosate
  • gadobutrol
  • teclistamab
  • tremelimumab
  • futibatinib
  • etranacogene dezaparvovec
  • olutasidenib
  • naproxen and diphenhydramine
  • naratriptan
  • gadopiclenol
  • gadoxetate
  • gadoversetamide
  • naphazoline/pheniramine
  • naphazoline
  • nalbuphine
  • vosoritide
  • vitamin K1 (phytonadione)
  • moxidectin
  • basiliximab
  • fecal microbiota, live-jslm
  • ibuprofen/famotidine
  • famotidine
  • raxibacumab
  • omalizumab
  • measles, mumps, rubella, and varicella vaccine, live (Rx)
  • senna/docusate
  • dinoprostone
  • measles mumps and rubella vaccine, live
  • immune globulin IM (IGIM)
  • dyclonine
  • doravirine, lamivudine, and tenofovir disoproxil fumarate
  • elexacaftor/tezacaftor/ivacaftor
  • ivacaftor/tezacaftor
  • treosulfan
  • tranexamic acid
  • norethindrone acetate/​estradiol/​elagolix
  • artesunate
  • trientine
  • trifarotene
  • ziconotide
  • vonoprazan/amoxicillin/clarithromycin
  • pyrithione zinc
  • zinc oxide topical
  • naphazoline/​zinc sulfate/​glycerin ophthalmic
  • voretigene neparvovec
  • nirmatrelvir/ritonavir
  • bebetelovimab
  • sodium chloride
  • relugolix/​estradiol/​norethindrone
  • defibrotide
  • prothionamide
  • liraglutide/insulin degludec
  • etilfrine
  • alpha-lipoic acid
  • ramosetron
  • olodaterol/tritropium
  • cimetropium
  • umeclidinium
  • itopride
  • secretin
  • naftopidil
  • trimeprazine
  • benperidol
  • chlormethiazole
  • multivitamins
  • secukinumab
  • glycopyrrolate inhaled and formoterol
  • amitriptyline and chlordiazepoxide
  • tirzepatide
  • relugolix/estradiol/norethindrone
  • mupirocin
  • alvimopan
  • chlordiazepoxide
  • insulin regular human
  • insulin aspart protamine/​insulin aspart
  • insulin isophane human/​insulin regular human
  • insulin degludec/insulin aspart
  • teplizumab
  • chlordiazepoxide/clidinium
  • aspirin, sodium bicarbonate, and citric acid
  • aluminum hydroxide, magnesium hydroxide, and simethicone
  • glycopyrrolate inhaled
  • olodaterol/tiotropium
  • umeclidinium bromide
  • timolol/dorzolamide
  • travoprost ophthalmic
  • loxapine
  • eptifibatide
  • hydrocodone/acetaminophen
  • omega 3 fatty acids
  • trandolapril/​verapamil
  • abciximab
  • artificial saliva
  • diphtheria, hepatitis B, pertussis (acellular), polio, and tetanus vaccine
  • diphtheria, haemophilus B, pertussis, polio, tetanus vaccine
  • haemophilus influenzae type b vaccine/hepatitis b vaccine
  • butalbital/aspirin/caffeine 
  • colchicine/probenecid
  • atovaquone and proguanil
  • ursodiol
  • chenodiol
  • casirivimab/imdevimab
  • tixagevimab/cilgavimab
  • molnupiravir
  • bebtelovimab
  • calcium, magnesium, potassium and sodium oxybate
  • sodium oxybate
  • diphtheria, polio, pertussis acellular, tetanus vaccine
  • pseudoephedrine loratadine
  • sodium chloride nasal
  • hydroxychloroquine sulfate
  • atorvastatin and ezetimibe
  • teriparatide
  • alendronate and cholecalciferol
  • alprostadil (IV)
  • romosozumab
  • risedronate
  • alendronate
  • glyburide/metformin
  • clorazepate
  • rosuvastatin/​ezetimibe
  • paclitaxel/encequidar
  • valsartan/amlodipine
  • enalapril/hydrochlorothiazide
  • enalapril and felodipine
  • amiloride/hydrochlorothiazide
  • triamterene/hydrochlorothiazide
  • lisinopril/hydrochlorothiazide
  • tegaserod
  • rhein
  • ritanserin
  • sulfaphenazole
  • sulconazole
  • taurursodiol
  • bromeperidol
  • carbapenems
  • fotemustine
  • difelikefalin
  • bromopride
  • alizapride
  • olopatadine
  • oxomemazine
  • paraldehyde
  • oxcarbazepine
  • kratom
  • elexacaftor
  • oritavancin
  • miocamycin
  • curcumin sulfate
  • seproxetine
  • clotrimazole
  • remacemide
  • piperine
  • ditiocarb
  • danoprevir
  • oxetacaine
  • topiroxostat
  • indisulam
  • tofisopam
  • noscapine
  • thiopental
  • tioconazole
  • nicotinamide
  • rutin
  • mequitazine
  • somatostatin
  • vapreotide
  • econazole
  • saracatinib
  • lestaurtinib
  • efonidipine
  • zimelidine
  • indalpine
  • desvenlafaxine
  • benidipine
  • dapoxetine
  • tesmilifene
  • pergolide
  • sitaxentan
  • resveratrol
  • bifonazole
  • tildipirosin
  • solithromycin
  • selamectin
  • imiquimod topical
  • fluorouracil topical
  • peginterferon alfa-2b
  • interferon alfa-2b
  • alteplase
  • tanshinone I
  • rosmarinic acid
  • caryophyllene
  • ursolic acid
  • cepharanthine
  • veliflapon
  • mirikizumab
  • cp-96345
  • famprofazone
  • peoniflorin
  • fepradinol
  • licofelone
  • polmacoxib
  • ebselen
  • taxifolin
  • betulinic acid
  • flurbiprofen axetil
  • talniflumate
  • morniflumate
  • nitroaspirin
  • firocoxib
  • ns-398
  • cimicoxib
  • robenacoxib
  • sc-236
  • imidazole salicylate
  • trolamine salicylate
  • pirprofen
  • benorilate
  • ethenzamide
  • mofebutazone
  • proquazone
  • carbaspirin calcium
  • guacetisal
  • proglumetacin
  • propyphenazone
  • pranoprofen
  • bendazac
  • tenidap
  • lonazolac
  • nifenazone
  • flunoxaprofen
  • difenpiramide
  • feprazone
  • bufexamac
  • alminoprofen
  • suxibuzone
  • fentiazac
  • tinoridine
  • tepoxalin
  • indobufen
  • flunixin
  • propacetamol
  • clonixin
  • droxicam
  • epirizole
  • etofenamate
  • ibuproxam
  • indoprofen
  • kebuzone
  • felbinac
  • zaltoprofen
  • azapropazone
  • zomepirac
  • niflumic acid
  • magnesium salicylate
  • suprofen
  • nepafenac
  • bromfenac
  • ciprofloxacin and hydrocortisone (otic) (Rx)
  • hydrocortisone/neomycin/polymyxin otic (Rx)
  • vigabatrine
  • valproate sodium injection
  • tezepelumab (Rx)
  • triamcinolone acetonide/nystatin
  • triamcinolone suprachoroidal (Rx)
  • triamcinolone, intranasal
  • ciclesonide inhaled
  • diosmin
  • tirbanibulin
  • padeliporfin
  • roxadustat
  • aminosalicylic acid
  • rasburicase
  • tetracaine
  • articaine
  • ropivacaine
  • nitrous oxide
  • sulfapyridine
  • sulfanilamide
  • mafenide
  • isometheptene
  • amyl nitrite
  • antipyrine
  • isosorbide dinitrate
  • prilocaine
  • nitroglycerin
  • tobacco
  • batefenterol
  • hexoprenaline
  • pf-00610355
  • racepinephrine
  • protokylol
  • doxofylline
  • phenylpropanolamine
  • isoetharine
  • ephedra sinica root
  • dipivefrin
  • arbutamine
  • norepinephrine
  • fenoterol
  • clenbuterol
  • pirbuterol
  • epinephrine
  • ritodrine
  • procaterol
  • orciprenaline
  • bitolterol
  • abediterol
  • fluticasone furoate, umeclidinium and vilanterol
  • fluticasone furoate and vilanterol
  • mometasone and formoterol
  • pramoxine topical (OTC)
  • menthol/pramoxine (topical)
  • tetrastarch
  • plasma protein fraction
  • hetastarch
  • rokitamycin
  • ridaforolimus
  • oleandomycin
  • patupilone
  • mitemcinal
  • midecamycin
  • mirvetuximab soravtansine
  • lorvotuzumab mertansine
  • kitasamycin
  • flurithromycin
  • eprinomectin
  • epofolate
  • epothilone D
  • coltuximab ravtansine
  • dirithromycin
  • doramectin
  • cethromycin
  • carbomycin
  • paramethasone
  • dexamethasone isonicotinate
  • quinupristin
  • sarilumab
  • dalfopristin
  • curcumin
  • luliconazole
  • procaine
  • chloroprocaine
  • phencyclidine
  • tenocyclidine
  • profenamine
  • halothane
  • lfenprodil
  • calcium levulinate
  • agmatine
  • calcium pangamate
  • calcium glubionate
  • edodekin alfa
  • beloranib
  • aflibercept
  • endostar
  • volociximab
  • roquinimex
  • anecortave acetate
  • squalamine
  • brolucizumab
  • trebananib
  • semaxanib
  • endostatin
  • halofuginone
  • resveratol
  • ranibizumab
  • fumagilin
  • bevacizumab
  • hyperforin
  • aminohippuric acid
  • opicapone
  • pafolacianine
  • bempedoic acid
  • belantamab mafodotin
  • prasterone
  • glecaprevir
  • levomenol
  • parachlorophenol
  • gadoxetic acid
  • cholecystokinin
  • caspofungin
  • ouabain
  • rifampicin
  • taurocholic acid
  • methylphosphinic acid
  • revefenacin
  • isoprenaline
  • posiphen
  • acotiamide
  • triflupromazine
  • pegvisomant
  • pipecuronium
  • regramostim
  • phenserine
  • diethylcarbamazine
  • cinchocaine
  • pancuronium
  • bambuterol
  • hexafluronium
  • aprotinin
  • tyrothricin
  • decamethonium
  • ipidacrine
  • tubocurarine
  • paraoxon
  • ginkgo biloba
  • methanesulfonyl fluoride
  • dichlorvos
  • fenthion
  • metrifonate
  • coumaphos
  • huperzine A
  • distigmine
  • neostigmine
  • isoflurophate
  • tasosartan
  • fimasartan
  • methylthioninium
  • minaprine
  • gallamine triethiodide
  • ambenonium
  • abiraterone
  • mibefradil
dexmedetomidine + 

diphenoxylate/atropine

may enhance the CNS depressant effect

phenobarbital

may enhance the CNS depressant effect

diphenhydramine

may enhance the CNS depressant effect

midazolam

may enhance the CNS depressant effect

sufentanil

may enhance the CNS depressant effect

diazepam

may increase the CNS depressant effect of CNS Depressants

methadone

may increase the CNS depressant effect of CNS Depressants

secobarbital

may increase the CNS depressant effect of CNS Depressants

apomorphine

may have an increased CNS depressant effect when combined with dexmedetomidine

flurazepam

may have an increased CNS depressant effect when combined with dexmedetomidine

perphenazine

may have an increased CNS depressant effect when combined with dexmedetomidine

clorazepic acid

may have an increased CNS depressant effect when combined with dexmedetomidine

isoflurane

may have an increased CNS depressant effect when combined with dexmedetomidine

promazine

may have an increased CNS depressant effect when combined with dexmedetomidine

carvedilol

may have an increased AV-blocking effect when combined with beta-blockers

methylphenidate

dexmedetomidine: they may increase the CNS depressant effect of CNS stimulants

viloxazine

dexmedetomidine: they may increase the CNS depressant effect of CNS stimulants

cocaine

dexmedetomidine: they may increase the CNS depressant effect of CNS stimulants

opium tincture 

may enhance the CNS depressant effect

paregoric 

may increase the CNS depressant effect

levorphanol 

may increase the CNS depressant effect

risperidone 

may increase the CNS depressant effect of CNS depressants

eszopiclone 

may increase the CNS depressant effect of CNS depressants

acrivastine and pseudoephedrine 

may increase the CNS depressant effect of CNS depressants

brimonidine and timolol 

may increase the AV-blocking effect of beta blockers

flibanserin 

may increase the CNS depressant effect of CNS depressants

carbinoxamine 

may increase the CNS depressant effect of CNS depressants

molindone 

may increase the CNS depressant effect of CNS depressants

methohexital 

may increase the CNS depressant effect of CNS depressants

thiothixene 

may increase the CNS depressant effect of CNS depressants

desflurane 

may increase the CNS depressant effect of CNS depressants

fexofenadine 

may increase the CNS depressant effect of CNS depressants

promethazine/dextromethorphan 

may increase the CNS depressant effect of CNS Depressants

phenobarbital 

may increase the CNS depressant effect of CNS Depressants

sevoflurane 

may increase the CNS depressant effect of CNS Depressants

aripiprazole 

may increase the CNS depressant effect of CNS Depressants

suvorexant 

may increase the CNS depressant effect of CNS Depressants

buprenorphine buccal 

may increase the CNS depressant effect of CNS Depressants

buprenorphine,long-acting injection 

may increase the CNS depressant effect of CNS Depressants

imipramine

They may increase the vasopressor effect when combined with Alpha-/Beta-Agonists

protriptyline

They may increase the vasopressor effect when combined with Alpha-/Beta-Agonists

trimipramine

They may increase the vasopressor effect when combined with Alpha-/Beta-Agonists

benzylpenicilloyl polylysine 

It may decrease the diagnostic effect when combined with Alpha-/Beta-Agonists

chlorzoxazone 

may increase the CNS depressant effect of CNS Depressants

acetaminophen/doxylamine/dextromethorphan 

may increase the CNS depressant effect CNS Depressants

protriptyline

may decrease the antihypertensive effect when combined with alpha2-agonists

methylergometrine 

may increase the vasoconstricting effect of Ergot Derivatives

rasagiline 

may increase the adverse effect of Monoamine Oxidase Inhibitors

lisuride 

It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists

levalbuterol

may enhance the AV-blocking effect of beta-blockers

acebutolol

may enhance the AV-blocking effect of beta-blockers

penbutolol

may enhance the AV-blocking effect of beta-blockers

pindolol

may enhance the AV-blocking effect of beta-blockers

propranolol

may enhance the AV-blocking effect of beta-blockers

levalbuterol

may increase the effect of beta-blockers

acebutolol

may increase the effect of beta-blockers

penbutolol

may increase the effect of beta-blockers

pindolol

may increase the effect of beta-blockers

propranolol

may increase the effect of beta-blockers

propranolol

may increase the effect of beta-blockers

mirabegron

may increase the AV-blocking effect

penbutolol

may increase the AV-blocking effect

timolol

may increase the AV-blocking effect

betaxolol

may increase the AV-blocking effect

bisoprolol

may increase the AV-blocking effect

phenylbutazone 

It may enhance the risk of nephrotoxicity when combined with phenylbutazone

nylidrin 

may enhance the risk or severity of hypertension when combined

desvenlafaxine

may decrease the therapeutic effect when combined with Alpha2-Agonists

duloxetine

may decrease the therapeutic effect when combined with Alpha2-Agonists

levomilnacipran

may decrease the therapeutic effect when combined with Alpha2-Agonists

milnacipran

may decrease the therapeutic effect when combined with Alpha2-Agonists

nefazodone

may decrease the therapeutic effect when combined with Alpha2-Agonists

oracit

may increase the serum concentration

shohls Solution

may increase the serum concentration

sodium lactate

may increase the serum concentration

sodium citrate

may increase the serum concentration

sodium bicarbonate

may increase the serum concentration

vasopressin 

It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists

spironolactone 

It may decrease the vasoconstricting effect when combined with Alpha-/Beta-Agonists

pergolide 

It may increase the hypertensive effect when combined with Alpha-/Beta-Agonists

clozapine 

It may decrease the therapeutic effect when combined with Alpha-/Beta-Agonists

kava 

may increase the effects of pharmacodynamic synergism