dexpanthenol topical

Action and Spectrum

Actions and Spectrum 

dexpanthenol is known for its moisturizing and hydrating properties. When applied topically, it is absorbed into the skin and converted into pantothenic acid, which is an essential component of coenzyme A. Coenzyme A plays a crucial role in various metabolic processes, including the synthesis of fatty acid.

Drug Interaction

Adverse Reaction

Frequency not defined  

Irritation 

Allergic reactions  

Itching 

Tingling 

Urticaria 

Black Box Warning

Black Box Warning 

None

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Individuals who are known to be allergic to dexpanthenol or any other components of a product should avoid using it. 

Caution: 

• Individuals with sensitive skin should perform a patch test before using a product containing dexpanthenol. 
• Avoid getting dexpanthenol-containing products into the eyes, as it could cause irritation. 
• Avoid applying it to open wounds or infected skin without medical supervision. 

Pregnancy / Lactation

Pregnancy consideration: 

Pregnancy category: C 

Lactation: Excretion of drug into human milk: likely or possible 

Pregnancy Categories:         

Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 

Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.  

Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 

Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 

Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 

Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology  

Coenzyme A is essential for the conversion of carbohydrates, fats, and proteins into usable energy in the form of adenosine triphosphate (ATP).  

dexpanthenol indirectly supports energy production by ensuring the availability of pantothenic acid for Coenzyme A synthesis. 

Pharmacodynamics 

Topical application of dexpanthenol, leading to the local availability of pantothenic acid, contributes to the regeneration of skin cells, maintenance of the skin’s moisture barrier, and reduction of trans epidermal water loss.  

Pharmacokinetics 

Absorption   

dexpanthenol absorbed through the skin. 

Distribution 

dexpanthenol is distributed throughout the body.  

Metabolism 

Metabolism occurs in the cells of various tissues including the liver. 

Elimination and excretion 

dexpanthenol is excreted in the urine. 

Adminstartion

Administration 

dexpanthenol is commonly used topically and available in the form of cream. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: dexpanthenol topical 

Why do we use dexpanthenol topical? 

dexpanthenol is widely used in skincare products for its moisturizing and skin barrier-enhancing properties.   

It helps to keep the skin hydrated, reduce dryness, and improve overall skin texture.   

dexpanthenol can be used on minor cuts, scrapes, and burns in the healing.