diastase

Action and Spectrum

Actions and spectrum: 

Actions: 

• Starch Digestion: diastase is primarily involved in the breakdown of complex carbohydrates, particularly starches, into simpler sugars. It catalyzes the hydrolysis of starch molecules into maltose and maltotriose, which are more easily absorbed in the digestive tract. 
• Digestive Aid: diastase acts as a digestive enzyme, assisting in the initial stages of carbohydrate digestion in the mouth and upper part of the digestive system. 

Spectrum: 

diastase’s spectrum of action is limited to carbohydrates, specifically starches. It does not have a broader spectrum of activity like some other digestive enzymes that can also break down proteins and fats. Its main role is to initiate the digestion of starches into more digestible sugar molecules. 

Drug Interaction

Adverse Reaction

Frequency not defined 

Diarrhea 

Stomach pain 

Bloating 

Black Box Warning

Black Box Warning: 

There are no well-documented black box warnings associated with diastase. 

Contraindication / Caution

Pregnancy / Lactation

Pregnancy consideration:  

pregnancy category: not assigned 

Lactation: excreted into human milk: unknown  

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

diastase is an enzyme that plays a pivotal role in carbohydrate digestion within the human body. Specifically, it acts as an amylase enzyme, which means it targets complex carbohydrates, particularly starches. diastase facilitates the hydrolysis of starch molecules, breaking them down into simpler sugars, such as maltose and maltotriose.

This enzymatic action takes place predominantly in the mouth and upper digestive tract during the initial stages of digestion. By converting starches into more easily absorbable sugars, diastase aids in the body’s absorption of nutrients and energy from dietary carbohydrates. It is often used as a digestive aid in various formulations, such as dietary supplements, to support efficient carbohydrate digestion.  

Pharmacodynamics: 

• Carbohydrate Digestion: diastase is an enzyme classified as an amylase, which means it specifically targets complex carbohydrates, such as starches. Its primary action is to catalyze the hydrolysis of starch molecules into simpler sugars. This enzymatic process involves breaking the glycosidic bonds that hold the starch molecules together. As a result, starches are broken down into smaller carbohydrates, including maltose and maltotriose. 
• Conversion to Simple Sugars: Through the action of diastase, complex starches are converted into simpler sugars. Maltose, in particular, is a disaccharide consisting of two glucose molecules linked together.  
• Facilitating Nutrient Absorption: By breaking down starches into more digestible forms, diastase contributes to the absorption of nutrients and energy from carbohydrates in the diet. This enzymatic activity supports the efficient utilization of dietary starches. 
• Digestive Aid: diastase is often used as a digestive aid in various formulations, such as dietary supplements, to assist individuals in digesting complex carbohydrates more effectively.

Pharmacokinetics: 

• Absorption: diastase is typically administered orally as part of digestive enzyme supplements. In the form of supplements, diastase is designed to be orally ingested. Once in the digestive tract, it begins to act on complex carbohydrates, primarily starches, in the food that is being consumed. 
• Distribution: diastase does not have a significant distribution phase in the body like drugs or substances that circulate through the bloodstream. Its action is localized to the digestive system, where it helps with carbohydrate digestion. 
• Metabolism: diastase is an endogenous enzyme, which means it is naturally produced by the body, particularly in the salivary glands and pancreas. The exogenous diastase used in supplements complements the body’s own production of this enzyme. 
• Elimination and excretion: diastase itself is not typically excreted from the body in the way that drugs are. Instead, it participates in the digestive process by facilitating the breakdown of starches into simpler sugars. These simpler sugars, such as maltose and maltotriose, are absorbed through the intestinal lining and then further metabolized and utilized for energy. 

Adminstartion

Administration: 

• Dosage: The recommended dosage of diastase can vary depending on the specific product and brand. Dosages are often measured in units or milligrams (mg).  
• Administration: diastase supplements are available in tablet, capsule, or liquid form. Administer the supplement as directed: Tablets/Capsules: Swallow the tablet or capsule whole with a glass of water. Liquid Form: If in liquid form, use a measuring device to measure the recommended dosage and take it with water or as instructed. 
• Timing: Take diastase as directed, either at the beginning or during your meal, depending on the product’s instructions. Some supplements recommend taking them before the meal, while others may suggest taking them with the meal. 
• Consistency: For individuals who require diastase on an ongoing basis to aid digestion, it is essential to be consistent with its use. Taking the supplement regularly with meals can help maintain consistent digestive support. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: diastase 

Pronounced: (DYE-uh-stays)  

Why do we use diastase? 

diastase is commonly used as a digestive enzyme supplement to aid in the efficient digestion of carbohydrates, especially starches. Its primary purpose is to break down complex starch molecules into simpler sugars like maltose and maltotriose. This enzymatic action takes place in the mouth and upper digestive tract, where it helps individuals digest starchy foods more effectively.

diastase is often utilized to relieve digestive discomfort, bloating, and gas that can result from consuming starchy meals. It also finds application in supporting individuals with certain digestive disorders and as a dietary aid for those on carbohydrate-rich diets, athletes, and seniors seeking improved carbohydrate absorption.