diazolidinylurea

Action and Spectrum

Actions and spectrum: 

Actions: 

• Antimicrobial Activity: diazolidinylurea functions as a broad-spectrum antimicrobial agent, which helps to prevent growth of bacteria, yeast, and mold in cosmetic and personal care products. 

Spectrum: 

diazolidinylurea’s antimicrobial spectrum includes a wide range of microorganisms commonly found in cosmetic and personal care products, such as: 

• Bacteria: Various types of bacteria, including both Gram-positive and Gram-negative species. 
• Yeast: Yeast species that can proliferate in water-containing products. 
• Mold: Certain molds and fungi that can thrive in cosmetic formulations. 

Drug Interaction

Adverse Reaction

Frequency not defined 

skin irritation, 

redness, 

itching, 

Allergic contact dermatitis 

inflammation,  

rash, 

blisters. 

eye irritation 

Black Box Warning

Black Box Warning: 

There is no specific black box warning associated with the use of diazolidinylurea. 

Contraindication / Caution

Contraindication/Caution: 

Contraindication: 

• Formaldehyde Allergy: diazolidinylurea releases formaldehyde over time, which can potentially trigger allergic reactions in individuals who are sensitive or allergic to formaldehyde. Those with known formaldehyde allergies should avoid products containing diazolidinylurea or consult a dermatologist before use. 
• Skin Sensitivity: Some individuals may have sensitive skin that can react to certain preservatives, including diazolidinylurea. People with a history of skin sensitivity or reactions to cosmetic products should perform a patch test before using products containing diazolidinylurea. 
• Open Wounds or Broken Skin: Products containing diazolidinylurea should not be applied to open wounds, cuts, or areas of broken or irritated skin, as this may increase the risk of irritation or sensitization. 
• Eye Area: Avoid applying products containing diazolidinylurea directly to the eye area, as it may cause irritation to the delicate skin around the eyes.

Caution: 

• Allergies and Sensitivities: While diazolidinylurea is well-tolerated, some individuals may be sensitive or allergic to the formaldehyde released by the compound. Those with a history of formaldehyde allergies or sensitivities should be cautious when using products containing diazolidinylurea. 
• Patch Testing: Individuals with a history of skin sensitivities or reactions should consider performing a patch test before using products containing diazolidinylurea.  
• Avoiding Ingestion and Eye Contact: Products containing diazolidinylurea should not be ingested or applied to the eye area.  
• Broken or Irritated Skin: Avoid applying products with diazolidinylurea to open wounds, cuts, or areas of broken or irritated skin, as this may increase the risk of irritation. 
• Children and Infants: While diazolidinylurea is considered safe for most individuals, products containing this ingredient should be used cautiously on children and infants, as their skin may be more sensitive. 
• Discontinue Use if Irritation Occurs: If skin irritation, redness, itching, or other adverse reactions occur after using products containing diazolidinylurea, discontinue use and consult a healthcare professional if necessary.

Comorbidities: 

• Skin Sensitivities: Individuals with a history of skin sensitivities, such as contact dermatitis or eczema, may be more prone to developing adverse reactions when using products containing diazolidinylurea. These individuals may experience itching, redness, or rash upon exposure. 
• Allergies to Formaldehyde: diazolidinylurea releases formaldehyde over time, which can trigger allergic reactions. Those who are known to be allergic to formaldehyde should be cautious when using products containing diazolidinylurea. 
• Existing Dermatological Conditions: Individuals with pre-existing skin conditions, such as psoriasis or rosacea, may have compromised skin barriers and may be more susceptible to irritation from cosmetic products containing diazolidinylurea. 
• Chemical Sensitivities: Some individuals may have sensitivities to certain chemicals found in cosmetics and personal care products. They may be more cautious when using products with various preservatives, including diazolidinylurea. 

Pregnancy / Lactation

Pregnancy consideration: pregnancy category: not assigned 

Lactation: excreted into human milk: No  

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.   
• Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women. 
• Category N: There is no data available for the drug under this category. 

Pharmacology

Pharmacology: 

diazolidinylurea is a chemical compound commonly used as a preservative in cosmetic & personal care products. Its pharmacological properties relate to its role as an antimicrobial agent. Upon application to products, diazolidinylurea gradually releases formaldehyde, which acts by inhibiting the growth of bacteria, yeast, and mold.

This helps extend the shelf life of cosmetic formulations and prevents product contamination. The antimicrobial action of diazolidinylurea contributes to the overall safety and stability of cosmetic and personal care products, ensuring their quality over time. While it provides important preservation benefits, individuals with sensitivities or allergies to formaldehyde should exercise caution when using products containing diazolidinylurea.  

Pharmacodynamics: 

• Antimicrobial Activity: diazolidinylurea functions as a formaldehyde-releasing preservative. When applied to products, it gradually releases formaldehyde, which acts as an antimicrobial agent. Formaldehyde is toxic to microorganisms, including bacteria, yeast, and molds, which can grow and thrive in water-containing cosmetic formulations. By releasing formaldehyde over time, diazolidinylurea helps prevent microbial growth, extending the shelf life of products and reducing the risk of contamination. 
• Broad-Spectrum Activity: diazolidinylurea’s antimicrobial effects cover a wide range of microorganisms, making it effective against various types of bacteria, yeast, and molds commonly found in cosmetic and personal care products. 
• pH and Formulation Impact: The efficacy of diazolidinylurea as a preservative can be influenced by factors such as the pH of the formulation and the specific combination of ingredients. Products with higher pH levels tend to release formaldehyde more readily. 

Pharmacokinetics: 

Absorption 

diazolidinylurea is typically applied topically to cosmetic and personal care products. It is not meant for direct application to the skin in its pure form. It may be absorbed to a limited extent through the skin, but systemic absorption is expected to be minimal. 

Distribution 

Due to its topical use in products, diazolidinylurea remains primarily localized to the site of application. It is not expected to have significant distribution throughout the body. 

Metabolism 

diazolidinylurea is not metabolized within the body since its primary function is as a preservative in cosmetic formulations. Any metabolic transformations would occur in the context of the formulation itself. 

Elimination and excretion 

The excretion of diazolidinylurea primarily occurs through its removal from the skin when the cosmetic or personal care product is washed off. It is not anticipated to undergo significant metabolic processing or systemic excretion. 

Adminstartion

Administration: 

diazolidinylurea is not administered directly to individuals as a standalone product. Instead, it is used as an ingredient in cosmetic and personal care products for its preservative properties.

When formulating products, manufacturers incorporate diazolidinylurea to prevent the growth of bacteria, yeast, and molds in the product, thereby extending its shelf life and ensuring its safety. 

Consumers do not need to administer diazolidinylurea themselves; they encounter it when using cosmetic and personal care items such as lotions, creams, shampoos, and other products that require preservation against microbial contamination. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: diazolidinylurea 

Pronounced: (dye-uh-zol-i-din-il-yoo-ree-uh)  

Why do we use diazolidinylurea? 

• Skincare Products: diazolidinylurea is often added to moisturizers, lotions, creams, and serums to prevent microbial contamination and maintain the product’s integrity. 
• Hair Care Products: It is used in shampoos, conditioners, and hair styling products to inhibit the growth of microorganisms that could spoil the formulation. 
• Body Wash and Cleansers: diazolidinylurea helps maintain the quality and safety of liquid and gel-based cleansers. 
• Makeup and Cosmetics: Many makeup products, such as foundations, mascaras, and eyeliners, contain diazolidinylurea to protect them from microbial growth. 
• Sunscreen and SPF Products: It is used in sunscreens and other sun protection products to ensure their efficacy and safety. 
• Baby Care Products: diazolidinylurea may be found in baby lotions, shampoos, and other products to maintain their sterility. 
• Personal Hygiene Products: Items like deodorants, soaps, and antiperspirants use diazolidinylurea to prevent microbial contamination. 
• Fragrances: Some fragrances and perfumes incorporate diazolidinylurea to preserve their quality. 
• Oral Care Products: Some toothpaste and oral care formulations may include diazolidinylurea to prevent microbial growth.