- March 15, 2022
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Brand Name :
Bentyl
Synonyms :
dicyclomine
Class :
Anticholinergic agents
Dosage forms & Strengths
Capsule
10 mg
Tablet
20 mg
Injectable solution
10mg/ml
Syrup
10mg/5ml
20 mg of dicyclomine is indicated orally every 6 hours
The dose can be increased to 40 mg every 6 hours if efficacy is not attained within 2 weeks
The maximum dose in the case of irritable bowel syndrome is 80 mg per day
For injection dose, 10-20 mg of the intramuscular dose every 6 hours is optimum
Dose consideration
The intramuscular dose should not be used for more than 1-2 days
Replace it with an oral dose as soon as possible
Do not use intravenous dose
Dosage forms & Strengths
Capsule
10 mg
Tablet
20 mg
Injectable solution
10mg/ml
Syrup
10mg/5ml
irritable bowel syndrome (IBS)
For infants of > 6 months of age: 5 mg orally every 6 to 8 hours
Do not exceed the dose of more than 20mg/day
Children: 10 mg orally every 6 to 8 hours
The dose should not exceed 40mg orally per day
Dosage forms & Strengths
Capsule
10 mg
Tablet
20 mg
Injectable solution
10mg/ml
Syrup
10mg/5ml
irritable bowel syndrome (IBS)
10-20 mg of the oral dose every 6 hours is recommended for geriatrics
Do not exceed the dose of more than 160 mg/day
Intramuscular injections are not advised for geriatric patients
it increases the toxicity of dicyclomine
it increases the toxicity of dicyclomine
pramlintide and dicyclomine increase the effect of each other through a synergistic activity
dicyclomine decreases the effect of revefenacin by decreasing the cholinergic transmission
dicyclomine decreases the effect of secretin by antagonistic activity
umeclidinium bromide and dicyclomine increase the toxicity of each other by synergism
anticholinergic agents increase the constipating activity of ramosetron
it increases the anticholinergic agents
it may diminish the therapeutic efficacy when combined with castor oil
dimenhydrinate increases the toxicity of dicyclomine due to pharmacodynamic synergism
it decreases the effect of dicyclomine by antagonistic activity
it decreases the effect of dicyclomine by antagonistic activity
trazodone and dicyclomine decrease the cholinergic transmission
Actions and Spectrum:
dicyclomine is a medication that belongs to the class of anticholinergic drugs, and it acts on the smooth muscles of the gastrointestinal (GI) tract. The actions and spectrum of dicyclomine can be summarized as follows:
The spectrum of dicyclomine includes its use in the treatment of various GI disorders, such as IBS, functional bowel disorders, diverticulitis, and peptic ulcers. dicyclomine is often used in combination with other medications, such as proton pump inhibitors (PPIs), to provide a comprehensive approach to the management of GI disorders. It is important to note that dicyclomine is a prescription medication and should only be used under the guidance of a healthcare professional.
Frequency defined
>10%
Dry mouth
Dizziness
Blurred vision
1-10%
Nervousness
Weakness
Somnolence
Frequency not defined
Abdominal distension
Confusion state
Cycloplegia
Delirium
Dermatitis
Erythema
Fatigue
Hallucinations
Insomnia
Malaise
Palpitation
Rash
Syncope
Contraindication/Caution:
dicyclomine has several contraindications and precautions that should be considered before use. These include:
Overall, dicyclomine should be used with caution in patients with certain medical conditions and should only be used under the guidance of a healthcare professional. It is important to inform the healthcare provider of any pre-existing medical conditions or medications being taken before starting dicyclomine therapy.
Pregnancy consideration:
Category B
Breastfeeding warnings: dicyclomine should not be taken by lactating females
Pregnancy category:
Pharmacology:
dicyclomine is a medication that belongs to the class of anticholinergic drugs, and it works by blocking the action of acetylcholine at muscarinic receptors in the smooth muscles of the gastrointestinal (GI) tract. This leads to relaxation of the smooth muscles and a decrease in spasms, which can help to reduce abdominal pain and cramping associated with various GI disorders.
dicyclomine is rapidly absorbed after oral administration, and it reaches peak plasma concentrations within 1 to 1.5 hours. The medication is metabolized in the liver and excreted in the urine and feces. The half-life of dicyclomine is approximately 1.5 to 2 hours, and the duration of action is 4 to 6 hours.
In addition to its antispasmodic effects, dicyclomine also has some local anesthetic effects on the GI tract, which can help to reduce pain and discomfort associated with GI spasms. dicyclomine can also reduce the secretion of gastric acid, which can be helpful in the treatment of peptic ulcers.
Pharmacodynamics:
dicyclomine is an anticholinergic medication that works by blocking the action of acetylcholine at muscarinic receptors in the smooth muscles of the gastrointestinal (GI) tract. This leads to the relaxation of the smooth muscles and a decrease in spasms, which can help to reduce abdominal pain and cramping associated with various GI disorders.
Acetylcholine is a neurotransmitter that stimulates smooth muscle contraction in the GI tract, and its effects are mediated through muscarinic receptors. dicyclomine competitively inhibits the binding of acetylcholine to muscarinic receptors, leading to reduced smooth muscle contractions and an overall decrease in GI spasms.
In addition to its antispasmodic effects, dicyclomine also has some local anesthetic effects on the GI tract, which can help to reduce pain and discomfort associated with GI spasms. dicyclomine can also reduce the secretion of gastric acid, which can be helpful in the treatment of peptic ulcers.
Pharmacokinetics:
Absorption
The bioavailability is 67% in an intramuscular injection
The onset of action is 1-2 hours
The duration of action is 4 hours
The peak plasma concentration for oral is achieved in 60-90 min
Distribution
The volume of distribution is 3.65 L/kg
Metabolism
The drug gets extensively metabolized in the liver
Elimination and Excretion
The half-life is 1.8 hours
The drug is excreted 80% in urine and 8% in feces
Administration:
dicyclomine is usually taken orally, and it is available in the form of capsules, tablets, or an oral solution. The medication should be taken with water, and it can be taken with or without food.
The dosage and frequency of dicyclomine administration depend on the specific condition being treated and the patient’s age, weight, and overall health. Typically, the recommended adult dose of dicyclomine for the treatment of functional bowel/irritable bowel syndrome is 20 mg four times daily, with the maximum dose of 40 mg four times daily.
For children, the recommended dose of dicyclomine is based on weight and is usually lower than the adult dose. The medication should not be used in children under six months of age.
dicyclomine should be taken as prescribed by a healthcare professional, and patients should not exceed the recommended dose or frequency of administration. It is important to follow the instructions provided by the healthcare professional and to continue taking the medication for the entire duration of the prescribed treatment.
Patient information leaflet
Generic Name: dicyclomine
Pronounced: dye-SYE-kloe-meen
Why do we use dicyclomine?
dicyclomine is a medication that is used to treat various gastrointestinal (GI) conditions that involve spasms, cramps, and pain. It is primarily used to treat functional bowel/irritable bowel syndrome, that is characterized by abdominal pain and discomfort, bloating, and changes in bowel habits.
In addition to functional bowel/irritable bowel syndrome, dicyclomine can also be used to treat other GI conditions, including:
dicyclomine works by relaxing the smooth muscles in the GI tract, which can help to reduce spasms and pain associated with these conditions. It can also reduce the secretion of gastric acid, which can be helpful in the treatment of peptic ulcers.
Overall, dicyclomine is a medication that acts on the smooth muscles of the GI tract to reduce spasms and pain associated with various GI disorders. It is important to note that dicyclomine is a prescription medication and should only be used under the guidance of a healthcare professional.