diethylpropion

Action and Spectrum

Actions and Spectrum: 

diethylpropion is a stimulant that is used as an appetite suppressant. It works by increasing the release of certain neurotransmitters like norepinephrine and dopamine, that reduce feelings of hunger. 

Drug Interaction

Adverse Reaction

1-10%: 

Palpitations 

Restlessness 

Impotence 

Menstrual irregularity 

Rash 

Stomach cramps 

Central nervous system stimulation 

Headache 

Xerostomia 

Insomnia 

Dizziness 

Vomiting 

Urticaria  

Blurred vision 

Mydriasis 

<1%: 

Cardiomyopathy 

Leukopenia 

Cerebrovascular accident 

Cerebral ischemia 

Primary pulmonary hypertension 

Psychotic disorder 

Black Box Warning

Black Box Warning: 

It is essential to follow the dosage and administration instructions for the medication carefully.  

Contraindication / Caution

Contraindication/Caution: 

diethylpropion should not be used in people hypersensitive to the drug itself. 

Pregnancy / Lactation

Pregnancy consideration:  

Category B 

Breastfeeding warnings:  

The drug is excreted in breast milk. Hence, use it with caution. 

Pregnancy category: 

• Category A: well-controlled and Satisfactory studies do not show risk to the fetus in the first/later trimester.        
• Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.        
• Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.       
• Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.        
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.        
• Category N: No data is available for the drug under this category. 

Pharmacology

Pharmacology 

diethylpropion is a stimulant that belongs to the class of drugs known as anorexiants. It increases the release of certain neurotransmitters, such as norepinephrine and dopamine, in the brain. These neurotransmitters help to reduce feelings of hunger and increase feelings of fullness, which can help to suppress appetite. 

diethylpropion also increases the release of epinephrine. This hormone increases heart rate and blood pressure. It can cause some side effects associated with the drug, such as increased heart rate and blood pressure, insomnia, and anxiety. 

Pharmacodynamics:  

diethylpropion is a stimulant that belongs to the class of drugs known as anorexiants. It increases the release of certain neurotransmitters, such as norepinephrine and dopamine, in the brain. These neurotransmitters help to reduce feelings of hunger and increase feelings of fullness, which can help to suppress appetite. 

It also increases the release of epinephrine, a hormone that can increase heart rate and blood pressure. It can cause some side effects associated with the drug, such as increased heart rate and blood pressure, insomnia, and anxiety. 

Pharmacokinetics:  

Pharmacokinetics studies how a drug is absorbed, distributed, metabolized, and eliminated by the body. The following parameters can describe the pharmacokinetics of diethylpropion. 

Absorption 

diethylpropion is rapidly absorbed in the gut and reaches peak plasma levels in about 2 hours. 

Distribution 

The volume of distribution is unknown. 

Metabolism 

The active metabolites are formed after the reduction and dealkylation. 

Elimination and excretion 

The half-life of the drug is 4-6 hours. 

The drug is majorly excreted in the urine. 

Adminstartion

Administration: 

The medication is taken orally as a tablet. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: diethylpropion 

Pronounced: dye-eth-ill-PROE-pee-on 

Why do we use diethylpropion? 

diethylpropion is used to treat obesity.