Security Lapse, Heavy Price: Cardiovascular Consultants Pays $3.85M
April 6, 2026
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Durezol
Synonyms :
difluprednate
Class :
Corticosteroids, Ophthalmic
Brand Name :
Durezol
Synonyms :
difluprednate
Class :
Corticosteroids, Ophthalmic
Dosage Forms & Strengths
Ophthalmic solution
0.05%
safety and efficacy not established
Refer to adult dosing
Actions and Spectrum:
difluprednate is a corticosteroid medication that is used to reduce inflammation and swelling. It belongs to a class of drugs called glucocorticoids, which mimic the effects of the hormone cortisol produced by the adrenal gland.
The main action of difluprednate is to reduce inflammation by inhibiting the activity of inflammatory cells and the production of inflammatory mediators. It also suppresses the immune system, helping to reduce the severity and duration of inflammation.
The spectrum of difluprednate includes a variety of inflammatory conditions, including:
Frequency Not Defined
Anterior chamber inflammation
Conjunctival edema
Corneal edema
Blepharitis
Optic nerve damage
Cataract
Abnormal healing (after surgery)
Local irritation
Punctate keratitis
Black Box Warning
difluprednate is a corticosteroid ophthalmic solution and it has a black box warning that states that it may cause an increase in intraocular pressure (IOP) and is associated with the development of cataracts and glaucoma, particularly with prolonged use.
Contraindication/Caution:
difluprednate, a type of corticosteroid medication, should not be used in individuals with a known hypersensitivity to the drug or any of its components. It should also be used with caution in individuals with a history of ocular herpes simplex, glaucoma, or cataracts, as well as those with a history of diabetes mellitus or hypertension.
Additionally, difluprednate should not be used for a prolonged period of time, as it can lead to the development of ocular hypertension or cataracts.
Pregnancy warnings:
US FDA pregnancy category: C
Lactation:
Excreted into human milk is unknown
Pregnancy Categories:
Category A: Studies that were well-controlled and met expectations revealed no risk to the fetus in either the first or second trimester.
Category B: There were a lack of studies on pregnant women and no evidence of risk to the foetus in animal experiments.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data available with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology:
difluprednate (Durezol) is a synthetic corticosteroid that is used for the treatment of inflammation and pain in the eye. It belongs to the class of drugs known as fluorinated corticosteroids, which are derivatives of prednisolone.
Pharmacodynamics:
difluprednate works by binding to the glucocorticoid receptor in the cells of the eye. This binding leads to the inhibition of the inflammatory cascade and the release of inflammatory mediators. The drug also has anti-angiogenic properties, which means it can inhibit the growth of new blood vessels in the eye.
Pharmacokinetics:
Absorption
difluprednate is administered topically as an ophthalmic solution and is rapidly absorbed by the cornea and conjunctiva.
Distribution
The onset of action is within 15 minutes of administration, and the effects last for up to 24 hours.
Metabolism
The drug is metabolized in the liver
Elimination and excretion
Excreted in the urine.
Administration:
Ophthalmic administration:
difluprednate is a topical ophthalmic corticosteroid medication used to treat inflammation and pain associated with eye conditions such as uveitis, iritis, and postoperative inflammation. It is typically administered as a 0.05% ophthalmic emulsion and should be instilled into the affected eye(s) as directed by a healthcare provider.
The recommended dosing schedule for difluprednate varies depending on the condition being treated, but it is typically administered one to two times daily.
Patient information leaflet
Generic Name: difluprednate
Why do we use difluprednate?
difluprednate is used to treat inflammation and pain associated with eye conditions such as uveitis, iritis, and postoperative inflammation. Uveitis is an inflammation of the uvea, which is the middle layer of the eye that contains blood vessels and pigmented cells. Iritis is an inflammation of the iris, which is the colored part of the eye. Both of these conditions can cause pain, redness, and blurred vision.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
