New Pathway Identified: Splenic Tr1 Cells Drive Transplant Tolerance via Areg–EGFR Signaling
January 8, 2026
Free CME credits
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
Brand Name :
Rimso 50
Synonyms :
dimethyl sulfoxide
Class :
Urologics
Brand Name :
Rimso 50
Synonyms :
dimethyl sulfoxide
Class :
Urologics
Dosage Forms & Strengths
Intravesicular solution
50%
Put 50 ml solution intravesicularly into the bladder and allow to remain there for about 15 minutes
It may repeat in every two weeks till the symptoms relief
Safety and efficacy not determined
Refer to adult dosing
dimethyl sulfoxide: they may decrease the therapeutic effect of dexrazoxane
may decrease the therapeutic effect when combined
dimethyl sulfoxide: they may increase the neurotoxic effect of sulindac
When dimethyl sulfoxide is used together with oliceridine, this leads to reduction in oliceridine’s metabolism
Actions and Spectrum
dimethyl sulfoxide can reduce the production of inflammatory molecules such as cytokines and prostaglandins, thereby suppressing inflammation. This action has led to its use in the treatment of inflammatory conditions, including arthritis, sports injuries, and interstitial cystitis. It also exhibits analgesic (pain-relieving) properties. It can block nerve conduction in peripheral sensory nerves, thereby reducing pain signals.
Frequency not defined
Garlic breath
Anaphylactoid reaction
Abnormal body odor
Pain following administration of agent
Garlic taste
Chemical cystitis, transient
Black Box Warning
None
Contraindication/Caution:
Contraindication:
Caution:
Pregnancy consideration:
Pregnancy category: C
Lactation: Excretion into human milk is unknown
Pregnancy Categories:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category.
Pharmacology
dimethyl sulfoxide possesses antioxidant properties and can scavenge free radicals, which helps protect cells from oxidative stress. It can neutralize reactive oxygen species and prevent cellular damage caused by oxidative processes.
Pharmacodynamics
dimethyl sulfoxide can enhance the permeability of cell membranes. It can disrupt the lipid bilayers of biological membranes, allowing for increased penetration of certain molecules.
Pharmacokinetics
Absorption
dimethyl sulfoxide can be well absorbed through various routes, including oral, topical, and parenteral administration.
Distribution
dimethyl sulfoxide can distribute widely throughout the body.
Metabolism
dimethyl sulfoxide undergoes limited metabolism in the body.
Elimination and excretion
The primary route of elimination for dimethyl sulfoxide is through the kidneys.
Administration
dimethyl sulfoxide is administered intravesically.
This involves the instillation of dimethyl sulfoxide directly into the bladder through a catheter.
Patient information leaflet
Generic Name: dimethyl sulfoxide
Why do we use dimethyl sulfoxide?
dimethyl sulfoxide is used for the treatment of interstitial cystitis, a chronic bladder condition characterized by bladder pain and urinary frequency. dimethyl sulfoxide also used as analgesic to relieve pain and reduce inflammation in conditions such as sprains and strains.
Both our subscription plans include Free CME/CPD AMA PRA Category 1 credits.
On course completion, you will receive a full-sized presentation quality digital certificate.
A dynamic medical simulation platform designed to train healthcare professionals and students to effectively run code situations through an immersive hands-on experience in a live, interactive 3D environment.
When you have your licenses, certificates and CMEs in one place, it's easier to track your career growth. You can easily share these with hospitals as well, using your medtigo app.
