2025 Guidelines for the Evaluation and Management of Adults With Congenital Heart Disease
December 19, 2025
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Brand Name :
Prepidil, prostin E2,Cervidil,prostaglandin E2
Synonyms :
Class :
Prostaglandins
Brand Name :
Prepidil, prostin E2,Cervidil,prostaglandin E2
Synonyms :
Class :
Prostaglandins
Dosage Forms & Strengths
Vaginal insert
10mg
Endocervical gel
0.5mg/3g
Vaginal suppository
20mg
One insert in posterior fornix, remove after 12 hours or on the onset of labor
2.5ml using catheter and syringe into the cervical canal, repeat after 6 hours
20mg suppository intravaginal every 3-5 hours until abortion occurs
Do not exceed more than two days of administration continuously
Refer adult dosing
may increase the effect of each other through pharmacodynamic synergism
When dinoprostone is used together with ouabain, this leads to reduction in dinoprostone excretion
the rate of excretion of dinoprostone may be reduced
may have a decrease in excretion when combined with dinoprostone
Frequency defined:
1-10%
Gel
Abnormal uterine contractions
Back pain
Fever
Warm feeling in the vagina
GI upset
Insert
Hypertonic uterine dysfunction with/without fetal distress
<1%
Gel
Uterine rupture
Amnionitis
Premature rupture of membranes
Intravascular coagulation
Insert
Uterine rupture
Hypotension
Frequency not defined:
Hot flash
Dehydration
Vulvitis
Eye pain
Chest pain
Syncope
Diaphoresis
Post-marketing reports
Headache
Anaphylactic shock
Pregnancy consideration: Insufficient data available
Lactation: Excretion of the drug in human breast milk is unknown
Pregnancy category:
Patient information leaflet
Generic Name: dinoprostone
Pronounced: dino-pro-s-tone
Why do we use dinoprostone?
In pregnant women who are at or close to term, it is used to prepare the cervix for the induction of labor
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